{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002218146327680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.13537"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.13537"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.13537"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.13537"}},{"identifier":{"@type":"PMID","@value":"29450944"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2019170896"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"NRF2 addiction in cancer cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The Kelch‐like <jats:styled-content style=\"fixed-case\">ECH</jats:styled-content>‐associated protein 1/nuclear factor erythroid‐derived 2‐like 2 (<jats:styled-content style=\"fixed-case\">KEAP</jats:styled-content>1‐<jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2) system is a pivotal defense mechanism against oxidative and electrophilic stress. Although transient <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 activation in response to stress is beneficial for health, persistent <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 activation in cancer cells has deleterious effects on cancer‐bearing hosts by conferring therapeutic resistance and aggressive tumorigenic activity on cancer cells. Because <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 increases the antioxidant and detoxification capability of cancer cells, persistently high levels of <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 activity enhance therapeutic resistance of cancer cells. <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 also drives metabolic reprogramming to establish cellular metabolic processes that are advantageous for cell proliferation in cooperation with other oncogenic pathways. As a result of these advantages, cancer cells with persistent activation of <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 often develop “<jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 addiction” and show malignant phenotypes leading to poor prognoses in cancer patients. Inhibition of <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 is a promising therapeutic approach for <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2‐addicted cancers and <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 inhibitors are being actively developed. However, giving systemic <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 inhibitors might have undesirable effects on cancer‐bearing hosts, considering the central roles of <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 in cytoprotection. To avoid these side‐effects, new therapeutic targets besides <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2 for <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2‐addicted cancers have been actively explored. This review introduces recent studies describing the development and characterization of <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2‐addicted cancers, as well as their potential therapeutic targets. Expected advances in diagnostic and therapeutic interventions for <jats:styled-content style=\"fixed-case\">NRF</jats:styled-content>2‐addicted cancers are also discussed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751148772608","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20706949"},{"@type":"NRID","@value":"1000020706949"},{"@type":"NRID","@value":"9000003011055"},{"@type":"NRID","@value":"9000004498077"},{"@type":"NRID","@value":"9000019040581"},{"@type":"NRID","@value":"9000402802746"},{"@type":"NRID","@value":"9000399378798"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000005508"}],"foaf:name":[{"@value":"Hiroshi Kitamura"}],"jpcoar:affiliationName":[{"@value":"Department of Gene Expression Regulation Institute of Development, Aging and Cancer Tohoku University Sendai Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276169262208","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00282351"},{"@type":"NRID","@value":"1000000282351"},{"@type":"NRID","@value":"9000276166266"},{"@type":"NRID","@value":"9000409578169"},{"@type":"NRID","@value":"9000410166962"},{"@type":"NRID","@value":"9000297486305"},{"@type":"NRID","@value":"9000283733081"},{"@type":"NRID","@value":"9000380434893"},{"@type":"NRID","@value":"9000356878950"},{"@type":"NRID","@value":"9000413525392"},{"@type":"NRID","@value":"9000391945097"},{"@type":"NRID","@value":"9000283649580"},{"@type":"NRID","@value":"9000018891723"},{"@type":"NRID","@value":"9000408497960"},{"@type":"NRID","@value":"9000398955730"},{"@type":"NRID","@value":"9000337076561"},{"@type":"NRID","@value":"9000413511543"},{"@type":"NRID","@value":"9000283731704"},{"@type":"NRID","@value":"9000019108240"},{"@type":"NRID","@value":"9000009763979"},{"@type":"NRID","@value":"9000390929924"},{"@type":"NRID","@value":"9000403438757"},{"@type":"NRID","@value":"9000410963136"},{"@type":"NRID","@value":"9000402802758"},{"@type":"NRID","@value":"9000000558597"},{"@type":"NRID","@value":"9000404481579"},{"@type":"NRID","@value":"9000021524120"},{"@type":"NRID","@value":"9000317154679"},{"@type":"NRID","@value":"9000410152384"},{"@type":"NRID","@value":"9000414929075"},{"@type":"NRID","@value":"9000413949483"},{"@type":"NRID","@value":"9000411115195"},{"@type":"NRID","@value":"9000283732992"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0138537"}],"foaf:name":[{"@value":"Hozumi Motohashi"}],"jpcoar:affiliationName":[{"@value":"Department of Gene Expression Regulation Institute of Development, Aging and Cancer Tohoku University Sendai Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2018-03-10","prism:volume":"109","prism:number":"4","prism:startingPage":"900","prism:endingPage":"911"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.13537"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.13537"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.13537"},{"@id":"https://search.jamas.or.jp/link/ui/2019170896"}],"createdAt":"2018-02-16","modifiedAt":"2023-09-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Carcinogenesis","dc:title":"Carcinogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=NF-E2-Related%20Factor%202","dc:title":"NF-E2-Related Factor 2"},{"@id":"https://cir.nii.ac.jp/all?q=Antineoplastic%20Agents","dc:title":"Antineoplastic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Antioxidants","dc:title":"Antioxidants"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Resistance,%20Neoplasm","dc:title":"Drug Resistance, Neoplasm"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Review%20Articles","dc:title":"Review Articles"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781975245440","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K19508"},{"@type":"JGN","@value":"JP17K19508"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19508/"}],"notation":[{"@language":"ja","@value":"精巣特異的代謝物による精子形成と次世代発生の制御プログラム"},{"@language":"en","@value":"Roles of testis-specific metabolites in spermatogenesis and their transgenerational impacts"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781993318528","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02621"},{"@type":"JGN","@value":"JP18H02621"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02621/"}],"notation":[{"@language":"ja","@value":"NRF2依存性がんの発症メカニズムの解明"},{"@language":"en","@value":"Pathogenesis of NRF2-addicted cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781994612864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H04794"},{"@type":"JGN","@value":"JP18H04794"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04794/"}],"notation":[{"@language":"ja","@value":"イオウ代謝制御による骨格筋パフォーマンス改善とその分子機構の解明"},{"@language":"en","@value":"Contribution of sulfur metabolism to skeletal muscle performance"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256929882112","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17F17116"},{"@type":"JGN","@value":"JP17F17116"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17F17116/"}],"notation":[{"@language":"ja","@value":"酸化ストレス応答転写因子ＮＲＦ２によるイオウ代謝を介した抗老化作用の検討"},{"@language":"en","@value":"Anti-aging function of NRF2 via sulfur metabolism."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256949477760","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K15591"},{"@type":"JGN","@value":"JP17K15591"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15591/"}],"notation":[{"@language":"ja","@value":"恒常的なNRF2の活性化がもたらす細胞老化誘導の意義とその分子機構の解明"},{"@language":"en","@value":"Verification of the significance and the molecular mechanism of cellular senescence induced by constitutive NRF2 activation"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215850221056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218992386432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219096057728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233956391168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235515644416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"p62/<scp>SQSTM</scp>1: ‘Jack of all trades’ in health and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235994103040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient Livers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236367028480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142935427200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutational landscape and significance across 12 major cancer types"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144603559168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168804419328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168804817920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The KEAP1-NRF2 System in Healthy Aging and Longevity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168850650624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690826946816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691778986368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691834184064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692363374464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693155958912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Accumulation of p62/<scp>SQSTM</scp>1 is associated with poor prognosis in patients with lung adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693446709760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693666849920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Myeloid Lineage–Specific Deletion of Antioxidant System Enhances Tumor Metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694774568320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707136902144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708404004992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709527990528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710969509376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710969553408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712912195968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 immunolocalization in human breast cancer patients as a prognostic factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617598749568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617609021312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617662846208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619374762368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619905507072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620701539584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancer related mutations in\n            <i>NRF2</i>\n            impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757164649344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166033277696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184629869952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185444020480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nuclear factor (erythroid‐derived 2)‐like 2 antioxidative response mitigates cytoplasmic radiation‐induced <scp>DNA</scp> double‐strand breaks"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185946219648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185947653504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186274733568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Simultaneous\n                    <i>K-ras</i>\n                    activation and\n                    <i>Keap1</i>\n                    deletion cause atrophy of pancreatic parenchyma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186320598656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095265456896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095341802752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Co-occurring Genomic Alterations on Outcomes in Patients with\n                    <i>KRAS</i>\n                    -Mutant Non–Small Cell Lung Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118724420864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The KEAP1/NRF2 Signaling Pathway in Keratinization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118758784768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118763149440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocellular Carcinoma: Cancer Metabolism and Immune Status"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580229776539648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genetic, metabolic and immunological features of cancers with <scp>NRF2</scp> addiction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580229780913280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232177766272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Revisiting therapeutic strategies for ovarian cancer by focusing on redox homeostasis (Review)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232406293888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641749081728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643613457536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655057255936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659695445632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567836846848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"F-Box Proteins and Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705578203264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855112142720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Complex Roles of Redox and Antioxidant Biology in Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131416065228288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metabolic features of cancer cells in NRF2 addiction status"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131420397756160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New addiction to the NRF2‐related factor NRF3 in cancer cells: Ubiquitin‐independent proteolysis through the 20S proteasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043433779584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043504398208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043769190656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045312886912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045359150848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045388647296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045600922880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519963387648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520319102592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694369417763712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"From germ cells to neonates: the beginning of life and the KEAP1–NRF2 system"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694370351219200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996361280896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975846225776000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468595419008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468901398784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Role of NRF2 in Cervical Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468951332608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2–Keap1 defines a physiologically important stress response mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470131219712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470277497728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944013708800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946193636736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419540609792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420110297472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420323974784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Expressions Correlate with WHO Grades in Gliomas and Meningiomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421054334208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896111293440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369262805760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369688266496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370964252544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in\n            <i>nrf2</i>\n            transcription factor-deficient mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843759127680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843867484288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844217857152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846085325440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846323744000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keap1 expression has independent prognostic value in pancreatic adenocarcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319249964160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 Is Essential for the Chemopreventive Efficacy of Oltipraz against Urinary Bladder Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319250248960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319621267712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of\n                    <i>KEAP1</i>\n                    /\n                    <i>NRF2</i>\n                    and\n                    <i>TP53</i>\n                    Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320659328512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321185557504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2 regulates serine biosynthesis in non–small cell lung cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793418865536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nrf2 is required to maintain the self-renewal of glioma stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269039481984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1370002218146327944","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Correlation of NRF2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004235489933056","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NRF2/Keap1 pathway and expression of oxidative stress lesions 8‐hydroxy‐2’‐deoxyguanosine and nitrotyrosine in melanoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004235489933057","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prognostic and predictive values of NRF2, Keap1, p16 and E‐cadherin expression in ovarian epithelial carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390862623771984896","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of KEAP1-NRF2 System and Sulfur Metabolism in Energy Production:"},{"@language":"ja","@value":"エネルギー代謝におけるKEAP1-NRF2制御系と硫黄代謝の役割"}]},{"@id":"https://cir.nii.ac.jp/crid/1520573726347144704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176767357696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation"},{"@value":"Keap-null mutation leads to postnatal lethality due to constitutive Nrf2 activation"},{"@value":"Keap1-null mutation leads to postnatal leathality due to constitutive Nrf2 activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075835424384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025704571648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026356323328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity"},{"@value":"Hepatocyte-specific deletion of the <italic>keap1</italic> gene activates Nrf2 and confers potent resistance against acute drug toxicity."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/cas.13537"},{"@type":"KAKEN","@value":"PRODUCT-22499088"},{"@type":"KAKEN","@value":"PRODUCT-22216754"},{"@type":"KAKEN","@value":"PRODUCT-21550387"},{"@type":"KAKEN","@value":"PRODUCT-22387458"},{"@type":"KAKEN","@value":"PRODUCT-22478850"},{"@type":"KAKEN","@value":"PRODUCT-22359927"},{"@type":"OPENAIRE","@value":"doi_dedup___::0a5e2be51cc43087d8a5887d10d8f04c"},{"@type":"CROSSREF","@value":"10.1111/febs.14712_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1111/cas.15143_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3390/antiox10121929_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3390/cancers13235956_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3390/cancers13030541_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1016/j.molcel.2020.10.010_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1038/s41467-020-19593-0_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1016/j.freeradbiomed.2022.06.239_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1271/kagakutoseibutsu.61.188_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1111/cas.13916_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3390/antiox9080751_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1016/j.jbc.2021.101032_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1002/hep4.1838_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1093/jb/mvac013_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1002/1873-3468.14458_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1016/j.freeradbiomed.2022.11.004_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3892/ol.2022.13200_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3892/or.2022.8386_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1093/toxsci/kfy233_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.3390/cancers12051249_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1038/s41374-022-00776-w_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1101/cshperspect.a041546_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1007/s12551-020-00659-8_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1111/cas.14244_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1093/jb/mvz070_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1111/cas.14278_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"},{"@type":"CROSSREF","@value":"10.1158/0008-5472.can-19-2888_references_DOI_GjX2264p2SRrkZQj0JbIC4ukjfz"}]}