{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002218459348992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/iai.00060-09"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/IAI.00060-09"}},{"identifier":{"@type":"PMID","@value":"19380474"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Shiga Toxin 2 Is Specifically Released from Bacterial Cells by Two Different Mechanisms"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Shiga toxin 1 (Stx1) is located in the periplasmic fraction, while Stx2 is found in the extracellular fraction, suggesting that enterohemorrhagic\n            <jats:italic>Escherichia coli</jats:italic>\n            (EHEC) contains a specific Stx2 release system. Both\n            <jats:italic>stx</jats:italic>\n            <jats:sub>1</jats:sub>\n            and\n            <jats:italic>stx</jats:italic>\n            <jats:sub>2</jats:sub>\n            are found within the late operons of Stx-encoding phages. Stx2 production is greatly induced by mitomycin C, suggesting that\n            <jats:italic>stx</jats:italic>\n            <jats:sub>2</jats:sub>\n            can transcribe from the late phage promoter of the Stx2-encoding phage. However, the Stx1 promoter adjacent to\n            <jats:italic>stx</jats:italic>\n            <jats:sub>1</jats:sub>\n            is a dominant regulatory element in Stx1 production. With the deletion of phage lysis genes of the Stx2-encoding phage, Stx2 remains in the bacterial cells. Further, we demonstrate that the Stx2-encoding phage, but not the Stx1-encoding phage, is spontaneously induced at extremely low rates. These results indicate that spontaneously specific Stx2-encoding phage induction is involved in specific Stx2 release from bacterial cells. Furthermore, to examine whether another system for specific Stx2 release is present in EHEC, we analyze the\n            <jats:italic>stx</jats:italic>\n            -replaced mutants. As expected, Stx2 derived from the Stx1 promoter is located in both the extracellular and cell-associated fractions, while mutant Stx2 (B subunit, S31N) derived from the Stx1 promoter is found only in the cell-associated fraction. These results indicate that EHEC has another Stx2 release system that strictly recognizes the serine 31 residue of the B subunit. Overall, we present evidence that specific Stx2 release from bacterial cells is involved in both the Stx2-encoding phage induction system and another Stx2 release system.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276166003840","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70312840"},{"@type":"NRID","@value":"1000070312840"},{"@type":"NRID","@value":"9000021803488"},{"@type":"NRID","@value":"9000292182218"},{"@type":"NRID","@value":"9000004260378"},{"@type":"NRID","@value":"9000024953672"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0062134"}],"foaf:name":[{"@value":"Takeshi Shimizu"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba, Japan 260-8670"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567185927008000","@type":"Researcher","foaf:name":[{"@value":"Yuko Ohta"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba, Japan 260-8670"}]},{"@id":"https://cir.nii.ac.jp/crid/1380567185927008001","@type":"Researcher","foaf:name":[{"@value":"Masatoshi Noda"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba, Japan 260-8670"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00199567"},{"@type":"EISSN","@value":"10985522"}],"prism:publicationName":[{"@value":"Infection and Immunity"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2009-07","prism:volume":"77","prism:number":"7","prism:startingPage":"2813","prism:endingPage":"2823"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/IAI.00060-09"}],"createdAt":"2009-04-21","modifiedAt":"2022-03-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Viral","dc:title":"Genes, Viral"},{"@id":"https://cir.nii.ac.jp/all?q=Prophages","dc:title":"Prophages"},{"@id":"https://cir.nii.ac.jp/all?q=Coliphages","dc:title":"Coliphages"},{"@id":"https://cir.nii.ac.jp/all?q=Shiga%20Toxin%202","dc:title":"Shiga Toxin 2"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Transport","dc:title":"Protein Transport"},{"@id":"https://cir.nii.ac.jp/all?q=Bacteriolysis","dc:title":"Bacteriolysis"},{"@id":"https://cir.nii.ac.jp/all?q=Enterohemorrhagic%20Escherichia%20coli","dc:title":"Enterohemorrhagic Escherichia coli"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Rabbits","dc:title":"Rabbits"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257060832384","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21590478"},{"@type":"JGN","@value":"JP21590478"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590478/"}],"notation":[{"@language":"ja","@value":"in vivo解析による志賀毒素産生様式の解明"},{"@language":"en","@value":"Study of Shiga toxin productions us ing in vivo analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257462880128","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19590440"},{"@type":"JGN","@value":"JP19590440"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590440/"}],"notation":[{"@language":"ja","@value":"グラム陰性病原細菌の病原分子分泌機構の解析"},{"@language":"en","@value":"Analysis of secretion system of virulence factor in gram-negative bacteria"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050867133850641664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239345912960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genomic Characterization of β-Glucuronidase–Positive<i>Escherichia coli</i>O157:H7 Producing Stx2a"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144702187008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional and genetic analysis of regulatory regions of coliphage H‐19B: location of shiga‐like toxin and lysis genes suggest a role for phage functions in toxin release"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145386479616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Purification and some properties of Shiga-like toxin from Escherichia coli 0157:H7 that is immunologically identical to Shiga toxin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282452430848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Occurrence and Reduction of Shiga Toxin-Producing Escherichia coli in Wastewaters in the Kathmandu Valley, Nepal"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618495725568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619792209792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacteriophage control of Shiga toxin 1 production and release by\n                    <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168154549120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The nitric oxide reductase of enterohaemorrhagic <i>Escherichia coli</i> plays an important role for the survival within macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180173549952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nitric oxide‐enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic\n                    <i>Escherichia coli</i>\n                    O157"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182121051648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Construction of a novel bioluminescent reporter system for investigating Shiga toxin expression of enterohemorrhagic Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182320908800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O157"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094919770880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distinctiveness of the genomic sequence of Shiga toxin 2-converting phage isolated from Escherichia coli O157:H7 Okayama strain as compared to other Shiga toxin 2-converting phages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118802042624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced production of Shiga toxin 1 in enterohaemorrhagic Escherichia coli by oxygen"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568452729984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shiga toxins even when different are encoded at identical positions in the genomes of related temperate bacteriophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568646963968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcription of the Shiga-like toxin type II and Shiga-like toxin type II variant operons of Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570594950400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Site of action of a Vero toxin (VT2) from <i>Escherichia coli</i> O157:H7 and of Shiga toxin on eukaryotic ribosomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570887416704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043770776832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Illnesses Associated with <i>Escherichia coli</i> 0157:H7 Infections"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044779667328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Serine 31 Residue of the B Subunit of Shiga Toxin 2 Is Essential for Secretion in Enterohemorrhagic\n            <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045730129408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shiga-Like Toxin-Converting Phages from\n            <i>Escherichia coli</i>\n            Strains That Cause Hemorrhagic Colitis or Infantile Diarrhea"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519179522176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism of Intrinsic Transcription Termination and Antitermination"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519744652544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locus"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519983438464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of antimicrobial agents, especially fosfomycin, on the production and release of Vero toxin by enterohaemorrhagic<i>Escherichia coli</i>O157:H7"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468347252352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469054874368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Escherichia coli O157: Lessons from the past 15 years"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469164090368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The pathogenic mechanisms of Shiga toxin and the Shiga‐like toxins"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470039114112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of type 1 fimbriae in EPEC infections"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470165091840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of a bacteriophage that carries the genes for production of Shiga-like toxin 1 in Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470320572032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role for a Phage Promoter in Shiga Toxin 2 Expression from a Pathogenic\n            <i>Escherichia coli</i>\n            Strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470828384512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcription antitermination: the λ paradigm updated"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944088740096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shiga and Shiga-like toxins."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944346630400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of the enterohemorrhagic Escherichia coli O157 DNA region containing lambdoid phage gene p and Shiga-like toxin structural genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944834687488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Southwestern Internal Medicine Conference: Shiga-like Toxins in Hemolytic-Uremic Syndrome and Thrombotic Thrombocytopenic Purpura"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945200281344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromosomal Integration of Heterologous DNA in\n            <i>Escherichia coli</i>\n            with Precise Removal of Markers and Replicons Used during Construction"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945384160768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacteriophage Control of Bacterial Virulence"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418462712192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<b>Two beginnings for a single purpose: the dual‐start holins in the regulation of phage lysis</b>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419848605312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Purification and some properties of a Vero toxin from Escherichia coli O157:H7 that is immunologically unrelated to Shiga toxin"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420392553344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"StcE, a metalloprotease secreted by <i>Escherichia coli</i> O157:H7, specifically cleaves C1 esterase inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420487743744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sequence of Shiga Toxin 2 Phage 933W from<i>Escherichia coli</i>O157:H7: Shiga Toxin as a Phage Late-Gene Product"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893620310656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mosaic structure of Shiga-toxin-2-encoding phages isolated from Escherichia coli O157:H7 indicates frequent gene exchange between lambdoid phage genomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894376946048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lysogenic Conversion by a Filamentous Phage Encoding Cholera Toxin"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894652203136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterizing spontaneous induction of Stx encoding phages using a selectable reporter system"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896245966464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mitomycin immunoblot colony assay for detection of Shiga-like toxin-producing Escherichia coli in fecal samples: comparison with DNA probes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368923231104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nucleotide sequence and promoter mapping of the Escherichia coli Shiga-like toxin operon of bacteriophage H-19B"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320311261952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influence of RecA onin vivovirulence and Shiga toxin 2 production inEscherichia colipathogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793266278656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nitric oxide inhibits Shiga-toxin synthesis by enterohemorrhagic\n            <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793626598656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome Analysis of a Novel Shiga Toxin 1 (Stx1)-Converting Phage Which Is Closely Related to Stx2-Converting Phages but Not to Other Stx1-Converting Phages"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794301739136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural Analysis of Phage-Borne\n            <i>stx</i>\n            Genes and Their Flanking Sequences in Shiga Toxin-Producing\n            <i>Escherichia coli</i>\n            and\n            <i>Shigella dysenteriae</i>\n            Type 1 Strains"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795052007168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795220020736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269311522560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270544665088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271175957248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206456330880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Studies on the mode of action of bacterial AB<sub>5</sub> toxins"},{"@language":"ja","@value":"病原細菌のAB<sub>5</sub>型トキシンの作用機構等に関する研究"},{"@value":"平成25年浅川賞受賞論文 病原細菌のAB₅型トキシンの作用機構等に関する研究"},{"@language":"ja-Kana","@value":"ヘイセイ 25ネン アサカワショウ ジュショウ ロンブン ビョウゲン サイキン ノ AB ₅ カタ トキシン ノ サヨウ キコウ トウ ニ カンスル ケンキュウ"},{"@value":"Studies on the mode of action of bacterial AB5 toxins"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681431477248","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression and extracellular release of Shiga toxin in enterohemorrahgic Escherichia coli"},{"@language":"ja","@value":"腸管出血性大腸菌が産生する志賀毒素の発現様式と菌体外への放出機構　‐志賀毒素転換ファージの構造と機能からの考察‐"},{"@value":"腸管出血性大腸菌が産生する志賀毒素の発現様式と菌体外への放出機構--志賀毒素転換ファージの構造と機能からの考察"},{"@language":"ja-Kana","@value":"チョウカン シュッケツセイ ダイチョウキン ガ サンセイ スル シガ ドクソ ノ ハツゲン ヨウシキ ト キンタイ ガイ エ ノ ホウシュツ キコウ シガ ドクソ テンカン ファージ ノ コウゾウ ト キノウ カラ ノ コウサツ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/iai.00060-09"},{"@type":"KAKEN","@value":"PRODUCT-12899838"},{"@type":"KAKEN","@value":"PRODUCT-12899854"},{"@type":"KAKEN","@value":"PRODUCT-11677560"},{"@type":"OPENAIRE","@value":"doi_dedup___::97cea0dd6c7c68776aef2c97a9d0816c"},{"@type":"CROSSREF","@value":"10.3201/eid2412.180404_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.3390/w14142224_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.1016/j.meegid.2015.04.027_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.1016/j.gene.2011.01.006_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.1111/j.1365-2958.2012.08122.x_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.1002/mbo3.461_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.3412/jsb.65.297_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.1099/mic.0.001122_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.1038/srep16663_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"},{"@type":"CROSSREF","@value":"10.3412/jsb.68.299_references_DOI_SiMVK9KVsaQZpij21HAt2y4HDI8"}]}