{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002218666226944.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2012/165879"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/mi/2012/165879.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/mi/2012/165879.xml"}},{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2012.03.152"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X1200633X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X1200633X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22503981"}},{"identifier":{"@type":"DOI","@value":"10.60692/tm4hp-xdv63"}},{"identifier":{"@type":"DOI","@value":"10.60692/196ym-62b74"}},{"identifier":{"@type":"PMID","@value":"22577245"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Inflammation may activate stem cells via prostaglandin E2 (PGE2) production mediated by cyclooxygenase-2 (COX-2) expression. We performed an immunohistochemical analysis of the expression of stemness markers (Oct3/4 and CD44v6) and COX-2 in urinary bladder tissues obtained from cystitis and cancer patients with and without<jats:italic>Schistosoma haematobium</jats:italic>infections. Immunoreactivity to Oct3/4 was significantly higher in<jats:italic>S. haematobium</jats:italic>-associated cystitis and cancer tissues than in normal tissues. CD44v6 expression was significantly higher in bladder cancer without<jats:italic>S. haematobium</jats:italic>than in normal tissues. COX-2 was located in the cytoplasmic membrane, cytoplasm, and nucleus of the cancer cells. Interestingly, the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the upregulation of Oct3/4 and CD44v6 in bladder cancer tissues with and without<jats:italic>S. haematobium</jats:italic>infection, respectively. COX-2 activation may be involved in inflammation-mediated stem cell proliferation/differentiation in urinary bladder carcinogenesis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232000472196","@type":"Researcher","foaf:name":[{"@value":"Raynoo Thanan"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagaki-cho, Suzuka, Mie 513-8670, Japan"},{"@value":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146938752","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10171141"},{"@type":"NRID","@value":"1000010171141"},{"@type":"NRID","@value":"9000006847521"},{"@type":"NRID","@value":"9000363399593"},{"@type":"NRID","@value":"9000003112021"},{"@type":"NRID","@value":"9000001307380"},{"@type":"NRID","@value":"9000107344577"},{"@type":"NRID","@value":"9000363399398"},{"@type":"NRID","@value":"9000237690280"},{"@type":"NRID","@value":"9000347094131"},{"@type":"NRID","@value":"9000022901383"},{"@type":"NRID","@value":"9000022901368"},{"@type":"NRID","@value":"9000363399157"},{"@type":"NRID","@value":"9000308729985"},{"@type":"NRID","@value":"9000257967126"},{"@type":"NRID","@value":"9000363399289"},{"@type":"NRID","@value":"9000283871117"},{"@type":"NRID","@value":"9000398608479"},{"@type":"NRID","@value":"9000363399391"},{"@type":"NRID","@value":"9000363399530"},{"@type":"NRID","@value":"9000398607281"},{"@type":"NRID","@value":"9000363399343"},{"@type":"NRID","@value":"9000363399652"},{"@type":"NRID","@value":"9000410014710"},{"@type":"NRID","@value":"9000398610129"},{"@type":"NRID","@value":"9000363399292"},{"@type":"NRID","@value":"9000414493809"},{"@type":"NRID","@value":"9000009802440"},{"@type":"NRID","@value":"9000257752609"},{"@type":"NRID","@value":"9000006341398"},{"@type":"NRID","@value":"9000242081624"},{"@type":"NRID","@value":"9000257822646"},{"@type":"NRID","@value":"9000363399349"},{"@type":"NRID","@value":"9000363399373"},{"@type":"NRID","@value":"9000004515767"},{"@type":"NRID","@value":"9000386257866"},{"@type":"NRID","@value":"9000363399290"},{"@type":"NRID","@value":"9000392028880"},{"@type":"NRID","@value":"9000398609238"},{"@type":"NRID","@value":"9000006640875"},{"@type":"NRID","@value":"9000024423558"},{"@type":"NRID","@value":"9000347193844"},{"@type":"NRID","@value":"9000283302055"},{"@type":"NRID","@value":"9000401955208"},{"@type":"NRID","@value":"9000257824631"},{"@type":"NRID","@value":"9000363399159"},{"@type":"NRID","@value":"9000391969461"},{"@type":"NRID","@value":"9000003913483"},{"@type":"NRID","@value":"9000398127840"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/mmurata580911"}],"foaf:name":[{"@value":"Mariko Murata"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000472192","@type":"Researcher","foaf:name":[{"@value":"Ning Ma"}],"jpcoar:affiliationName":[{"@value":"Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie 510-0293, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847871870415108","@type":"Researcher","foaf:name":[{"@value":"Olfat Hammam"}],"jpcoar:affiliationName":[{"@value":"Departments of Pathology and Urology, Theodor Bilharz Research Institute, Giza, Egypt"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847871870415111","@type":"Researcher","foaf:name":[{"@value":"Mohamed Wishahi"}],"jpcoar:affiliationName":[{"@value":"Departments of Pathology and Urology, Theodor Bilharz Research Institute, Giza, 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Dismutase"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Deoxyguanosine","dc:title":"Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Nitric%20Oxide%20Synthase%20Type%20II","dc:title":"Nitric Oxide Synthase Type II"},{"@id":"https://cir.nii.ac.jp/all?q=Proton%20Pump%20Inhibitors","dc:title":"Proton Pump Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Barrett%20Esophagus","dc:title":"Barrett Esophagus"},{"@id":"https://cir.nii.ac.jp/all?q=Esophagus","dc:title":"Esophagus"},{"@id":"https://cir.nii.ac.jp/all?q=8-Hydroxy-2'-Deoxyguanosine","dc:title":"8-Hydroxy-2'-Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Damage","dc:title":"DNA 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