{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002219091601408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dev.083774"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/dev/article-pdf/139/23/4356/1575185/4356.pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cellular communication across tissues is an essential process during embryonic development. Secreted factors with potent morphogenetic activity are key elements of this cross-talk, and precise regulation of their expression is required to elicit appropriate physiological responses. MicroRNAs (miRNAs) are versatile post-transcriptional modulators of gene expression. However, the large number of putative targets for each miRNA hinders the identification of physiologically relevant miRNA-target interactions. Here we show that miR-1 and miR-206 negatively regulate angiogenesis during zebrafish development. Using target protectors, our results indicate that miR-1/206 directly regulate the levels of Vascular endothelial growth factor A (VegfA) in muscle, controlling the strength of angiogenic signaling to the endothelium. Conversely, reducing the levels of VegfAa, but not VegfAb, rescued the increase in angiogenesis observed when miR-1/206 were knocked down. These findings uncover a novel function for miR-1/206 in the control of developmental angiogenesis through the regulation of VegfA, and identify a key role for miRNAs as regulators of cross-tissue signaling.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380569413852518404","@type":"Researcher","foaf:name":[{"@value":"Antonio J. Giraldez"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA"},{"@value":"Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380569413852518278","@type":"Researcher","foaf:name":[{"@value":"Yajaira Suárez"}],"jpcoar:affiliationName":[{"@value":"Division of Cardiology/Department of Medicine, New York University School of Medicine, New York, NY 10016, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380569413852518403","@type":"Researcher","foaf:name":[{"@value":"Carlos Stahlhut"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380569413852518155","@type":"Researcher","foaf:name":[{"@value":"Jun Lu"}],"jpcoar:affiliationName":[{"@value":"Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380569413852518411","@type":"Researcher","foaf:name":[{"@value":"Yuichiro Mishima"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779129"},{"@type":"PISSN","@value":"09501991"}],"prism:publicationName":[{"@value":"Development"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2012-12-01","prism:volume":"139","prism:number":"23","prism:startingPage":"4356","prism:endingPage":"4365"},"reviewed":"false","url":[{"@id":"http://journals.biologists.com/dev/article-pdf/139/23/4356/1575185/4356.pdf"}],"createdAt":"2012-11-06","modifiedAt":"2021-04-26","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782190733696","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24115711"},{"@type":"JGN","@value":"JP24115711"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24115711/"}],"notation":[{"@language":"ja","@value":"発生分化過程におけるｍｉｃｒｏＲＮＡシステムの動作原理と制御機構"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360001113999729664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein 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