{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002219092129792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/jcs.024224"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/jcs/article-pdf/121/7/1107/1502106/1107.pdf"}},{"identifier":{"@type":"PMID","@value":"18354085"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in cell regulation, including cell cycle progression, although their precise role in mitotic progression remains elusive. To address this issue, the effects of HDAC inhibition were examined upon a variety of mitotic mutants of the fission yeast Schizosaccharomyces pombe, which contains three HDACs that are sensitive to trichostatin A (TSA) and are similar to human HDACs. Here it is shown that HDACs are implicated in sister chromatid cohesion and separation. A mutant of the cohesin loader Mis4 (adherin) was hypersensitive to TSA and synthetically lethal with HDAC deletion mutations. TSA treatment of mis4 mutant cells decreased chromatin-bound cohesins in the chromosome arm region. By contrast, HDAC inhibitors and clr6 HDAC mutations rescued temperature sensitive (ts) phenotypes of the mutants of the ubiquitin ligase complex anaphase-promoting complex/cyclosome (APC/C), which display metaphase arrest. This suppression coincided with facilitated complex formation of APC/C. Moreover, our mass spectrometry analysis showed that an APC/C subunit, Cut23/APC8, is acetylated. HATs and HDACs might directly target adherin and APC/C to ensure proper chromosome segregation, and anti-tumour effects of HDAC inhibitors could be attributed to this deregulation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380850888896943232","@type":"Researcher","foaf:name":[{"@value":"Yuu Kimata"}],"jpcoar:affiliationName":[{"@value":"CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan"},{"@value":"Cell Cycle Control Group, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850888896943364","@type":"Researcher","foaf:name":[{"@value":"Akihisa Matsuyama"}],"jpcoar:affiliationName":[{"@value":"Chemical Genetics Laboratory, RIKEN Institute, Wako, Saitama 351-0198, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326211753984","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60426575"},{"@type":"NRID","@value":"1000060426575"},{"@type":"NRID","@value":"9000326666152"},{"@type":"NRID","@value":"9000329009057"},{"@type":"NRID","@value":"9000022778044"},{"@type":"NRID","@value":"9000250177978"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kngo"}],"foaf:name":[{"@value":"Koji Nagao"}],"jpcoar:affiliationName":[{"@value":"CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850888896943488","@type":"Researcher","foaf:name":[{"@value":"Kanji Furuya"}],"jpcoar:affiliationName":[{"@value":"CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326204829824","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00273855"},{"@type":"NRID","@value":"1000000273855"},{"@type":"NRID","@value":"9000326666153"},{"@type":"NRID","@value":"9000347092164"},{"@type":"NRID","@value":"9000329009058"},{"@type":"NRID","@value":"9000255679817"},{"@type":"NRID","@value":"9000242544695"},{"@type":"NRID","@value":"9000023804692"},{"@type":"NRID","@value":"9000410265276"},{"@type":"NRID","@value":"9000398991928"},{"@type":"NRID","@value":"9000397943779"},{"@type":"NRID","@value":"9000237871264"},{"@type":"NRID","@value":"9000391972998"},{"@type":"NRID","@value":"9000347093007"},{"@type":"NRID","@value":"9000398611107"},{"@type":"NRID","@value":"9000412104314"},{"@type":"NRID","@value":"9000399008767"},{"@type":"NRID","@value":"9000253181146"},{"@type":"NRID","@value":"9000022781617"},{"@type":"NRID","@value":"9000016928003"},{"@type":"NRID","@value":"9000250177979"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/obuse"}],"foaf:name":[{"@value":"Chikashi Obuse"}],"jpcoar:affiliationName":[{"@value":"CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850888896943363","@type":"Researcher","foaf:name":[{"@value":"Minoru Yoshida"}],"jpcoar:affiliationName":[{"@value":"Chemical Genetics Laboratory, RIKEN Institute, Wako, Saitama 351-0198, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850888896943360","@type":"Researcher","foaf:name":[{"@value":"Mitsuhiro Yanagida"}],"jpcoar:affiliationName":[{"@value":"CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779137"},{"@type":"PISSN","@value":"00219533"}],"prism:publicationName":[{"@value":"Journal of Cell Science"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2008-04-01","prism:volume":"121","prism:number":"7","prism:startingPage":"1107","prism:endingPage":"1118"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://journals.biologists.com/jcs/article-pdf/121/7/1107/1502106/1107.pdf"}],"createdAt":"2008-03-19","modifiedAt":"2021-09-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Chromatin%20Immunoprecipitation","dc:title":"Chromatin Immunoprecipitation"},{"@id":"https://cir.nii.ac.jp/all?q=Mitosis","dc:title":"Mitosis"},{"@id":"https://cir.nii.ac.jp/all?q=Ubiquitin-Protein%20Ligase%20Complexes","dc:title":"Ubiquitin-Protein Ligase Complexes"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatids","dc:title":"Chromatids"},{"@id":"https://cir.nii.ac.jp/all?q=Hydroxamic%20Acids","dc:title":"Hydroxamic Acids"},{"@id":"https://cir.nii.ac.jp/all?q=Anaphase-Promoting%20Complex-Cyclosome","dc:title":"Anaphase-Promoting Complex-Cyclosome"},{"@id":"https://cir.nii.ac.jp/all?q=Histone%20Deacetylases","dc:title":"Histone Deacetylases"},{"@id":"https://cir.nii.ac.jp/all?q=Mass%20Spectrometry","dc:title":"Mass Spectrometry"},{"@id":"https://cir.nii.ac.jp/all?q=Fungal%20Proteins","dc:title":"Fungal Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Histone%20Deacetylase%20Inhibitors","dc:title":"Histone Deacetylase Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Schizosaccharomyces","dc:title":"Schizosaccharomyces"},{"@id":"https://cir.nii.ac.jp/all?q=Sister%20Chromatid%20Exchange","dc:title":"Sister Chromatid Exchange"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257004664576","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20114006"},{"@type":"JGN","@value":"JP20114006"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20114006/"}],"notation":[{"@language":"ja","@value":"プロテオミクスによる遺伝情報発現の場の理解"},{"@language":"en","@value":"Elucidation of molecular basis of the field for gene expression by proteomics"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004237563476992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Condensin HEAT Subunits Required for DNA Repair, Kinetochore/Centromere Function and Ploidy Maintenance in Fission Yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144116617856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective mitosis due to a mutation in the gene for a fission yeast 26S protease 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yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570809320192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission Yeast Eso1p Is Required for Establishing Sister Chromatid Cohesion during S Phase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571136521344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2–M transition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571262249600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anticancer activities of histone deacetylase inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044144838400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission 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Forms Specialized Chromatin Required for Equal Segregation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419693507328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420071225984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420856232320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893849301376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894438323200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895193208320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histone deacetylase inhibitors in cancer therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895487061248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation of a Schizosaccharomyces pombe rad21ts Mutant That Is Aberrant in Chromosome Segregation, Microtubule Function, DNA Repair and Sensitive to Hydroxyurea: Possible Involvement of Rad21 in Ubiquitin-Mediated Proteolysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896328899584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368902541696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Proteomics Approach to Identify Proliferating Cell Nuclear Antigen (PCNA)-binding Proteins in Human Cell Lysates"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369037553792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A WD Repeat Protein Controls the Cell Cycle and Differentiation by Negatively Regulating Cdc2/B-Type Cyclin Complexes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369783931904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Divergence between Histone Deacetylases in Fission Yeast by Distinct Cellular Localization and In Vivo Specificity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370664271744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370775606784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>phd1</i><sup>+</sup>, a histone deacetylase gene of <i>Schizosaccharomyces pombe</i>, is required for the meiotic cell cycle and resistance to trichostatin A<sup>1</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843366192896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission Yeast Ste9, a Homolog of Hct1/Cdh1 and Fizzy-related, Is a Novel Negative Regulator of Cell Cycle Progression during G<sub>1</sub>-Phase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843884571520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Conditional Lethal Mutant in the Fission Yeast 26 S Protease Subunit mts3+ Is Defective in Metaphase to Anaphase Transition"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318677951872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Yeast TAFII145 Required for Transcription of G1/S Cyclin Genes and Regulated by the Cellular Growth State"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319763229824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G<sub>1</sub> phase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320530306816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation and characterization of\n                    <i>Schizosaccharomyces pombe cut</i>\n                    mutants that block nuclear division but not cytokinesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320586745088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Ubiquitin-Conjugating Enzyme in Fission Yeast That Is Essential for the Onset of Anaphase in Mitosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320708879488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Esa1p Is an Essential Histone Acetyltransferase Required for Cell Cycle Progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794204092800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress 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