{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002219518417536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1378/chest.11-2091"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0012369212604450?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0012369212604450?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22281802"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Increase of 27-Hydroxycholesterol in the Airways of Patients With COPD"}],"description":[{"notation":[{"@value":"27-Hydroxycholesterol (27-OHC) is produced from cholesterol by sterol 27-hydroxylase as an intermediate in the biosynthesis pathway of bile acid. Recently, 27-OHC was reported to cause inflammation and apoptosis in various types of cells. The aim of this study was to assess the production of 27-OHC in the airways of patients with COPD and to elucidate the possible role of 27-OHC in the tissue fibrosis of COPD.Lung tissues were obtained from six control subjects and six patients with COPD, and sputum samples were obtained from 11 healthy subjects and 15 patients with COPD. The expression of sterol 27-hydroxylase in the lung was investigated by immunohistochemistry. The amounts of 27-OHC in the sputum were quantified by the liquid chromatography-tandem mass spectrometry method. Because peribronchial fibrosis in peripheral airways is involved in the airflow limitation of COPD, we investigated the profibrotic effects of 27-OHC in vitro.The expression of sterol 27-hydroxylase was significantly enhanced in the lung tissues of patients with COPD compared with control subjects. The amounts of 27-OHC in the sputum were significantly increased in the patients with COPD (P.01), and the degree of 27-OHC production was negatively correlated with lung function (P.01). 27-OHC augmented the differentiation of lung fibroblasts into myofibroblasts and the production of extracellular matrix protein through activation of nuclear factor-κB and subsequent transforming growth factor-β(1) upregulation.27-OHC production is enhanced in the airways of patients with COPD and might be involved in the pathogenesis of COPD."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380284922855656577","@type":"Researcher","foaf:name":[{"@value":"Kanako 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Kikuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326229548160","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20445092"},{"@type":"NRID","@value":"1000020445092"},{"@type":"NRID","@value":"9000367402997"},{"@type":"NRID","@value":"9000409630194"},{"@type":"NRID","@value":"9000404122335"},{"@type":"NRID","@value":"9000319052725"},{"@type":"NRID","@value":"9000257948541"},{"@type":"NRID","@value":"9000016382647"},{"@type":"NRID","@value":"9000021889548"},{"@type":"NRID","@value":"9000346935847"},{"@type":"NRID","@value":"9000415410903"},{"@type":"NRID","@value":"9000021352513"},{"@type":"NRID","@value":"9000409334824"},{"@type":"NRID","@value":"9000356605143"},{"@type":"NRID","@value":"9000388473334"},{"@type":"NRID","@value":"9000283408082"},{"@type":"NRID","@value":"9000402798951"},{"@type":"NRID","@value":"9000021432248"},{"@type":"NRID","@value":"9000350630854"},{"@type":"NRID","@value":"9000022071142"},{"@type":"NRID","@value":"9000404122351"},{"@type":"NRID","@value":"9000411963937"},{"@type":"NRID","@value":"9000319052498"},{"@type":"NRID","@value":"9000411964019"},{"@type":"NRID","@value":"9000283774724"},{"@type":"NRID","@value":"9000283110115"},{"@type":"NRID","@value":"9000399802001"},{"@type":"NRID","@value":"9000411963947"},{"@type":"NRID","@value":"9000006807018"},{"@type":"NRID","@value":"9000360549080"},{"@type":"NRID","@value":"9000411964355"},{"@type":"NRID","@value":"9000411211861"},{"@type":"NRID","@value":"9000406400790"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000005491"}],"foaf:name":[{"@value":"Hisatoshi 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Koarai"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751137410304","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20405450"},{"@type":"NRID","@value":"1000020405450"},{"@type":"NRID","@value":"9000257948537"},{"@type":"NRID","@value":"9000001953244"},{"@type":"NRID","@value":"9000021889540"},{"@type":"NRID","@value":"9000021352491"},{"@type":"NRID","@value":"9000257949676"},{"@type":"NRID","@value":"9000257947913"},{"@type":"NRID","@value":"9000021432261"},{"@type":"NRID","@value":"9000022071150"},{"@type":"NRID","@value":"9000404122353"},{"@type":"NRID","@value":"9000411963927"},{"@type":"NRID","@value":"9000345250738"},{"@type":"NRID","@value":"9000404122345"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tomtom"}],"foaf:name":[{"@value":"Tomohiro Ichikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801183846144","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20347602"},{"@type":"NRID","@value":"1000020347602"},{"@type":"NRID","@value":"9000253623686"},{"@type":"NRID","@value":"9000404637857"},{"@type":"NRID","@value":"9000257947609"},{"@type":"NRID","@value":"9000410332665"},{"@type":"NRID","@value":"9000411837647"},{"@type":"NRID","@value":"9000402121459"},{"@type":"NRID","@value":"9000257948535"},{"@type":"NRID","@value":"9000368406296"},{"@type":"NRID","@value":"9000001422695"},{"@type":"NRID","@value":"9000329014377"},{"@type":"NRID","@value":"9000242078992"},{"@type":"NRID","@value":"9000398266711"},{"@type":"NRID","@value":"9000410045353"},{"@type":"NRID","@value":"9000021889520"},{"@type":"NRID","@value":"9000412545584"},{"@type":"NRID","@value":"9000004672984"},{"@type":"NRID","@value":"9000021352461"},{"@type":"NRID","@value":"9000257949673"},{"@type":"NRID","@value":"9000257947910"},{"@type":"NRID","@value":"9000408792129"},{"@type":"NRID","@value":"9000021432286"},{"@type":"NRID","@value":"9000411956303"},{"@type":"NRID","@value":"9000022071140"},{"@type":"NRID","@value":"9000406047205"},{"@type":"NRID","@value":"9000356605207"},{"@type":"NRID","@value":"9000283774725"},{"@type":"NRID","@value":"9000283110111"},{"@type":"NRID","@value":"9000398139323"},{"@type":"NRID","@value":"9000410037084"},{"@type":"NRID","@value":"9000257949702"},{"@type":"NRID","@value":"9000356562526"},{"@type":"NRID","@value":"9000309172918"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0207495"}],"foaf:name":[{"@value":"Kazuto Matsunaga"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284922855656709","@type":"Researcher","foaf:name":[{"@value":"Tsunahiko Hirano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284922855656704","@type":"Researcher","foaf:name":[{"@value":"Keiichirou Akamatsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284922855656579","@type":"Researcher","foaf:name":[{"@value":"Satoru Yanagisawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00123692"}],"prism:publicationName":[{"@value":"Chest"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2012-08","prism:volume":"142","prism:number":"2","prism:startingPage":"329","prism:endingPage":"337"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0012369212604450?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0012369212604450?httpAccept=text/plain"}],"createdAt":"2012-01-26","modifiedAt":"2025-09-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Extracellular%20Matrix%20Proteins","dc:title":"Extracellular Matrix Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Vital%20Capacity","dc:title":"Vital Capacity"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Culture%20Techniques","dc:title":"Cell Culture Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Sputum","dc:title":"Sputum"},{"@id":"https://cir.nii.ac.jp/all?q=Bronchi","dc:title":"Bronchi"},{"@id":"https://cir.nii.ac.jp/all?q=Fibroblasts","dc:title":"Fibroblasts"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Fibrosis","dc:title":"Fibrosis"},{"@id":"https://cir.nii.ac.jp/all?q=Hydroxycholesterols","dc:title":"Hydroxycholesterols"},{"@id":"https://cir.nii.ac.jp/all?q=Pulmonary%20Disease,%20Chronic%20Obstructive","dc:title":"Pulmonary Disease, Chronic Obstructive"},{"@id":"https://cir.nii.ac.jp/all?q=Case-Control%20Studies","dc:title":"Case-Control Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Forced%20Expiratory%20Volume","dc:title":"Forced Expiratory Volume"},{"@id":"https://cir.nii.ac.jp/all?q=Cholestanetriol%2026-Monooxygenase","dc:title":"Cholestanetriol 26-Monooxygenase"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782213489152","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24591136"},{"@type":"JGN","@value":"JP24591136"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591136/"}],"notation":[{"@language":"ja","@value":"ＣＯＰＤ患者の予後改善に向けた新しい個別化治療ストラテジーの構築"},{"@language":"en","@value":"The development of personalized treatment for patients with COPD"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257101876608","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22591097"},{"@type":"JGN","@value":"JP22591097"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591097/"}],"notation":[{"@language":"ja","@value":"喫煙喘息におけるステロイド抵抗性の病態解明"},{"@language":"en","@value":"Steroid-resistant mechanism in smoking asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257143648512","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23591126"},{"@type":"JGN","@value":"JP23591126"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591126/"}],"notation":[{"@language":"ja","@value":"慢性閉塞性肺疾患におけるオキシステロールの役割の解明"},{"@language":"en","@value":"Role of oxysterols on pathogenesis of chronic obstructive pulmoanry disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257190261632","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24591174"},{"@type":"JGN","@value":"JP24591174"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591174/"}],"notation":[{"@language":"ja","@value":"好酸球性肺炎における窒素化ストレス及び新たな炎症性メディエーターの解明"},{"@language":"en","@value":"Investigation of nitrosative stress and new inflammatory mediator in patients with eosinophilic pneumonia"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360001114266046080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143887464704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary 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