{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002220128463744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2215/cjn.08110811"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/01277230-201209000-00004"}},{"identifier":{"@type":"PMID","@value":"22700887"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Relationships between Levels of Urinary Podocalyxin, Number of Urinary Podocytes, and Histologic Injury in Adult Patients with IgA Nephropathy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:sec><jats:title>Background and objectives</jats:title><jats:p>Podocalyxin (PCX) is present on the apical cell membrane of podocytes and is shed in urine from injured podocytes. Urinary podocalyxin (u-PCX) is associated with severity of active glomerular injury in patients with glomerular diseases. This study examined the relationship between number of urinary podocytes, levels of u-PCX, and glomerular injury in adults with IgA nephropathy (IgAN).</jats:p></jats:sec><jats:sec><jats:title>Design, setting, participants, & measurements</jats:title><jats:p>Urine samples voided in the morning on the day of biopsy were obtained from 51 patients with IgAN (18 men and 33 women; mean age, 31 years). All renal biopsy specimens were analyzed histologically. Pathologic variables of IgAN were analyzed per Shigematsu classification, the Oxford classification of IgAN, and the Clinical Guidelines of IgAN in Japan. Levels of u-PCX were measured by sandwich ELISA.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Histologic analysis based on Shigematsu classification revealed a significant correlation between levels of u-PCX and severity of acute extracapillary abnormalities (<jats:italic toggle=\"yes\">r</jats:italic>=0.72;<jats:italic toggle=\"yes\">P</jats:italic><0.001), but levels of urinary protein excretion did not correlate with acute glomerular abnormalities. Levels of urinary protein excretion in patients with segmental sclerosis (<jats:italic toggle=\"yes\">n</jats:italic>=19) were higher than in patients without (<jats:italic toggle=\"yes\">n</jats:italic>=22) (0.49 [interquartile range (IQR), 0.20–0.88] g/g creatinine versus 0.20 [IQR, 0.10–0.33] g/g creatinine;<jats:italic toggle=\"yes\">P</jats:italic><0.01). The number of urinary podocytes in patients with segmental sclerosis was higher than in patients without (1.05 [IQR, 0.41–1.67] per mg creatinine versus 0.28 [IQR, 0.10–0.66] per mg creatinine;<jats:italic toggle=\"yes\">P</jats:italic><0.01).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Levels of u-PCX and the number of urinary podocytes are associated with histologic abnormalities in adults with IgAN.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566398496654851","@type":"Researcher","foaf:name":[{"@value":"Rin Asao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654721","@type":"Researcher","foaf:name":[{"@value":"Katsuhiko Asanuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654852","@type":"Researcher","foaf:name":[{"@value":"Fumiko Kodama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654849","@type":"Researcher","foaf:name":[{"@value":"Miyuki Akiba-Takagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654720","@type":"Researcher","foaf:name":[{"@value":"Yoshiko Nagai-Hosoe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654859","@type":"Researcher","foaf:name":[{"@value":"Takuto Seki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654850","@type":"Researcher","foaf:name":[{"@value":"Yukihiko Takeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654854","@type":"Researcher","foaf:name":[{"@value":"Isao Ohsawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654855","@type":"Researcher","foaf:name":[{"@value":"Satoshi Mano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654848","@type":"Researcher","foaf:name":[{"@value":"Kiyoshi Matsuoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654856","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Kurosawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654860","@type":"Researcher","foaf:name":[{"@value":"Shinya Ogasawara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654858","@type":"Researcher","foaf:name":[{"@value":"Yoshiaki Hirayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654857","@type":"Researcher","foaf:name":[{"@value":"Sakari Sekine"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654861","@type":"Researcher","foaf:name":[{"@value":"Satoshi Horikoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654862","@type":"Researcher","foaf:name":[{"@value":"Masanori Hara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566398496654853","@type":"Researcher","foaf:name":[{"@value":"Yasuhiko Tomino"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15559041"}],"prism:publicationName":[{"@value":"Clinical Journal of the American Society of Nephrology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2012-09","prism:volume":"7","prism:number":"9","prism:startingPage":"1385","prism:endingPage":"1393"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://journals.lww.com/01277230-201209000-00004"}],"createdAt":"2012-06-15","modifiedAt":"2025-03-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulosclerosis,%20Focal%20Segmental","dc:title":"Glomerulosclerosis, Focal Segmental"},{"@id":"https://cir.nii.ac.jp/all?q=Podocytes","dc:title":"Podocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Biopsy","dc:title":"Biopsy"},{"@id":"https://cir.nii.ac.jp/all?q=Sialoglycoproteins","dc:title":"Sialoglycoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme-Linked%20Immunosorbent%20Assay","dc:title":"Enzyme-Linked Immunosorbent Assay"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulonephritis,%20IGA","dc:title":"Glomerulonephritis, IGA"},{"@id":"https://cir.nii.ac.jp/all?q=Urine","dc:title":"Urine"},{"@id":"https://cir.nii.ac.jp/all?q=Sensitivity%20and%20Specificity","dc:title":"Sensitivity and Specificity"},{"@id":"https://cir.nii.ac.jp/all?q=Severity%20of%20Illness%20Index","dc:title":"Severity of Illness Index"},{"@id":"https://cir.nii.ac.jp/all?q=Proteinuria","dc:title":"Proteinuria"},{"@id":"https://cir.nii.ac.jp/all?q=Young%20Adult","dc:title":"Young Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Predictive%20Value%20of%20Tests","dc:title":"Predictive Value of Tests"},{"@id":"https://cir.nii.ac.jp/all?q=Creatinine","dc:title":"Creatinine"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Progression","dc:title":"Disease Progression"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257143791360","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23591201"},{"@type":"JGN","@value":"JP23591201"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591201/"}],"notation":[{"@language":"ja","@value":"ポドサイトにターゲットを絞った腎障害メカニズムの解明と新規治療薬の開発"},{"@language":"en","@value":"Tlanslating podocyte biology into new therapys and examinations for podocyte injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257207199872","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24790856"},{"@type":"JGN","@value":"JP24790856"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790856/"}],"notation":[{"@language":"ja","@value":"カテプシンＬ・カテプシンＤのポドサイトにおける役割と蛋白尿発現メカニズムの解明"},{"@language":"en","@value":"The role of lysosomal proteases in podocytes"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050292726807578752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A novel splicing variant of small nucleolar RNA host gene 4 is a podocyte-selective non-coding RNA upregulated in response to puromycin aminonucleoside-induced podocyte injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218991744512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"TWEAK/Fn14 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I. Immunohistochemical studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620162449152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dendrin Location in Podocytes Is Associated with Disease Progression in Animal and Human Glomerulopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757437012224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Podocytes are lost from glomeruli before completing apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865734848384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Early growth response 1 as a podocyte injury marker in human glomerular diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187513138688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Significance of Urinary Full-Length Megalin in Patients with IgA Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340707657728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Urinary podocyte markers of disease activity, therapeutic efficacy, and long-term outcomes in acute and chronic kidney diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643828796800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The correlation of urinary podocytes and podocalyxin with histological features of lupus nephritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568817291136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045438133504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Podocyte membrane vesicles in urine originate from tip vesiculation of podocyte microvilli"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046240361216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early treatment with corticosteroids ameliorates proteinuria, proliferative lesions, and mesangial phenotypic modulation in adult diffuse proliferative IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518755037184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Focal segmental glomerular sclerosis: The cellular lesion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521433495552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Podocyte Injury Predicts Prognosis in Patients with IgA Nephropathy Using a Small Amount of Renal Biopsy Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995755464960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cumulative Excretion of Urinary Podocytes Reflects Disease Progression in IgA Nephropathy and Scho[Combining Diaeresis]nlein-Henoch Purpura Nephritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995820857472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469589942528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parietal epithelia cells in the urine as a marker of disease activity in glomerular diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470460841984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Cloning and Characterization of Human Podocalyxin-like Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470536467200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Podocyte Biology and Response to Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943892636544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. 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