{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002220967828992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4161/org.28351"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.4161/org.28351"}},{"identifier":{"@type":"PMID","@value":"24589751"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"In vitro reconstitution of pancreatic islets"}],"description":[{"notation":[{"@value":"The lack of transplantable pancreatic islets is a serious problem that affects the treatment of patients with type 1 diabetes mellitus. Beta cells can be induced from various sources of stem or progenitor cells, including induced pluripotent stem cells in the near future; however, the reconstitution of islets from β cells in culture dishes is challenging. The generation of highly functional islets may require three-dimensional spherical cultures that resemble intact islets. This review discusses recent advances in the reconstitution of islets. Several factors affect the reconstitution of pseudoislets with higher functions, such as architectural similarity, cell-to-cell contact, and the production method. The actual transplantation of naked or encapsulated pseudoislets and islet-like cell clusters from various stem cell sources is also discussed. Advancing our understanding of the methods used to reconstitute pseudoislets should expand the range of potential strategies available for developing de novo islets for therapeutic applications."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801202655616","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90342956"},{"@type":"NRID","@value":"1000090342956"},{"@type":"NRID","@value":"9000002717047"},{"@type":"NRID","@value":"9000002931192"},{"@type":"NRID","@value":"9000255879507"},{"@type":"NRID","@value":"9000020269968"},{"@type":"NRID","@value":"9000401957556"},{"@type":"NRID","@value":"9000021672033"},{"@type":"NRID","@value":"9000021754307"},{"@type":"NRID","@value":"9000020311180"},{"@type":"NRID","@value":"9000365539464"},{"@type":"NRID","@value":"9000020133877"},{"@type":"NRID","@value":"9000240067851"},{"@type":"NRID","@value":"9000258675583"},{"@type":"NRID","@value":"9000258675616"},{"@type":"NRID","@value":"9000004530256"},{"@type":"NRID","@value":"9000257859599"},{"@type":"NRID","@value":"9000345305100"},{"@type":"NRID","@value":"9000006568796"},{"@type":"NRID","@value":"9000403161946"},{"@type":"NRID","@value":"9000257731476"},{"@type":"NRID","@value":"9000016656944"},{"@type":"NRID","@value":"9000258675607"},{"@type":"NRID","@value":"9000021710039"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nobuhikokojima"}],"foaf:name":[{"@value":"Nobuhiko Kojima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15476278"},{"@type":"EISSN","@value":"15558592"}],"prism:publicationName":[{"@value":"Organogenesis"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2014-03-03","prism:volume":"10","prism:number":"2","prism:startingPage":"225","prism:endingPage":"230"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.tandfonline.com/doi/pdf/10.4161/org.28351"}],"createdAt":"2014-03-03","modifiedAt":"2024-05-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Islets%20of%20Langerhans","dc:title":"Islets of Langerhans"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Islets%20of%20Langerhans%20Transplantation","dc:title":"Islets of Langerhans Transplantation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Regeneration","dc:title":"Regeneration"},{"@id":"https://cir.nii.ac.jp/all?q=Artificial%20Organs","dc:title":"Artificial Organs"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Communication","dc:title":"Cell Communication"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257202685312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24710142"},{"@type":"JGN","@value":"JP24710142"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710142/"}],"notation":[{"@language":"ja","@value":"ボトムアップ的手法による細胞集積型バイオマイクロデバイスの構築"},{"@language":"en","@value":"Fabrication of cell-based bio-microdevice by bottom-up approach"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050852252677733504","@type":"Article","resourceType":"学術雑誌論文(journal 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