{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004229989115136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/chem.201202809"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201202809"}},{"identifier":{"@type":"URI","@value":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201202809"}},{"identifier":{"@type":"PMID","@value":"23281056"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Ruthenium Complexes with Hydrophobic Ligands That Are Key Factors for the Optical Imaging of Physiological Hypoxia"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The phosphorescence emission of ruthenium complexes was applied to the optical imaging of physiological hypoxia. We prepared three complexes with hydrophobic substituents on the phenanthroline ligand and characterized their emission, which was quenched by molecular oxygen. Among the complexes synthesized in this study, a pyrene chromophore‐linked ruthenium complex, Ru‐Py, exhibited optimal properties for the imaging of hypoxia; the prolonged lifetime of the triplet excited state of the ruthenium chromophore, which was induced by efficient energy distribution and transfer from the pyrene unit, provided the highest sensitivity towards molecular oxygen. The introduction of hydrophobic pyrene increased the lipophilicity of the complex, leading to enhanced cellular uptake. Consequently, the bright phosphorescence of Ru‐Py was seen in the cytoplasm of viable hypoxic cells, whereas the signal from aerobic cells was markedly weaker. Thus, we could clearly discriminate between hypoxic and aerobic cells by monitoring the phosphorescence emission. Furthermore, Ru‐Py was applied to optical imaging in live mice. An intramuscular injection of Ru‐Py successfully visualized ischemia‐based hypoxia, which was constructed by leg banding.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658864151552","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10407140"},{"@type":"NRID","@value":"1000010407140"},{"@type":"NRID","@value":"9000021290546"},{"@type":"NRID","@value":"9000005922618"},{"@type":"NRID","@value":"9000391935627"}],"foaf:name":[{"@value":"Hirokazu Komatsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004229989115145","@type":"Researcher","foaf:name":[{"@value":"Kazuki Yoshihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326225147776","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80512764"},{"@type":"NRID","@value":"1000080512764"},{"@type":"NRID","@value":"9000311070105"},{"@type":"NRID","@value":"9000258594945"},{"@type":"NRID","@value":"9000023400074"},{"@type":"NRID","@value":"9000410999938"},{"@type":"NRID","@value":"9000413895123"},{"@type":"NRID","@value":"9000239617561"},{"@type":"NRID","@value":"9000333087360"},{"@type":"NRID","@value":"9000336045143"},{"@type":"NRID","@value":"9000018767434"},{"@type":"NRID","@value":"9000323844239"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000008732"}],"foaf:name":[{"@value":"Hisatsugu Yamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004229989115009","@type":"Researcher","foaf:name":[{"@value":"Yu Kimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004229989115013","@type":"Researcher","foaf:name":[{"@value":"Aoi Son"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016861857584768","@type":"Researcher","foaf:name":[{"@value":"Sei‐ichi Nishimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004229989115016","@type":"Researcher","foaf:name":[{"@value":"Kazuhito Tanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09476539"},{"@type":"EISSN","@value":"15213765"}],"prism:publicationName":[{"@value":"Chemistry – A European Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2012-12-20","prism:volume":"19","prism:number":"6","prism:startingPage":"1971","prism:endingPage":"1977"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201202809"},{"@id":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201202809"}],"createdAt":"2012-12-21","modifiedAt":"2025-10-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Pyrenes","dc:title":"Pyrenes"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Structure","dc:title":"Molecular Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Photochemistry","dc:title":"Photochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Pyridines","dc:title":"Pyridines"},{"@id":"https://cir.nii.ac.jp/all?q=Optical%20Imaging","dc:title":"Optical Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Ligands","dc:title":"Ligands"},{"@id":"https://cir.nii.ac.jp/all?q=Ruthenium","dc:title":"Ruthenium"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Coordination%20Complexes","dc:title":"Coordination Complexes"},{"@id":"https://cir.nii.ac.jp/all?q=Luminescent%20Measurements","dc:title":"Luminescent Measurements"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Hypoxia","dc:title":"Hypoxia"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrophobic%20and%20Hydrophilic%20Interactions","dc:title":"Hydrophobic and Hydrophilic Interactions"},{"@id":"https://cir.nii.ac.jp/all?q=Phenanthrolines","dc:title":"Phenanthrolines"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782180544896","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23710268"},{"@type":"JGN","@value":"JP23710268"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710268/"}],"notation":[{"@language":"ja","@value":"多重共鳴NMR法を用いた生体内化学反応プロセスの動的挙動解析"},{"@language":"en","@value":"Analysis of In Situ Chemical Reaction Dynamics by a Multiple Resonance NMR Technique"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782182663808","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23750081"},{"@type":"JGN","@value":"JP23750081"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23750081/"}],"notation":[{"@language":"ja","@value":"定量的低酸素イメージングプローブの開発"},{"@language":"en","@value":"Quantitative imaging probe for hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782249734784","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25350977"},{"@type":"JGN","@value":"JP25350977"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25350977/"}],"notation":[{"@language":"ja","@value":"多重共鳴NMR技術を基盤とする生体分子イメージングの新手法の開拓"},{"@language":"en","@value":"Development of New Tools for In Vivo Molecular Imaging Based on a Multiple-resonance NMR Technology"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282676917246336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"(13)C-labeled indolequinone-DTPA-Gd conjugate for NMR probing cytochrome:P450 reductase-mediated one-electron reduction."}]},{"@id":"https://cir.nii.ac.jp/crid/1050297836152749440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phosphonated mesoporous silica nanoparticles bearing ruthenium complexes used as molecular probes for tracking oxygen levels in cells and tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760667443072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"αvβ3-Integrin-targeting lanthanide complex: synthesis and evaluation as a tumor-homing luminescent probe."}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215832592256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216619114624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for <i>in Vivo</i> Imaging of Tumor Hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216659218560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Monitoring of Biological One-Electron Reduction by <sup>19</sup>F NMR Using Hypoxia Selective Activation of an <sup>19</sup>F-Labeled Indolequinone Derivative"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004229979631104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aggregate Formation of Oligonucleotides that Assist Molecular Imaging for Tracking of the Oxygen Status in Tumor Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004229979780224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tracking the Oxygen Status in the Cell Nucleus with a Hoechst‐Tagged Phosphorescent Ruthenium Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144181896192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ratiometric oxygen sensing: detection of dual-emission ratio through a single emission filter"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144276173056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Luminescence Lifetime Imaging of Oxygen, pH, and Carbon Dioxide Distribution Using Optical Sensors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144626049664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bioreductive fluorescent markers for hypoxic cells: a study of 2-nitroimidazoles with 1-substituents containing fluorescent, bridgehead-nitrogen, bicyclic systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145427758976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fluorescent cationic probes for nuclei of living cells: why are they selective? A quantitative structure–activity relations analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016869651332480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Water‐Soluble Luminescence Oxygen Sensor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619301252736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A dual-emissive-materials design concept enables tumour hypoxia imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170643580288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ratiometric Molecular Probes Based on Dual Emission of a Blue Fluorescent Coumarin and a Red Phosphorescent Cationic Iridium(III) Complex for Intracellular Oxygen Sensing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180030117376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DNA Microenvironment Monitored by Controlling Redox Blinking"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181970578560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Preparation of alkyne-labeled 2-nitroimidazoles for identification of tumor hypoxia by Raman spectroscopy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183067240960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intracellular and in Vivo Oxygen Sensing Using Phosphorescent Ir(III) Complexes with a Modified Acetylacetonato Ligand"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093861713664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tuning the luminescence lifetimes of ruthenium(ii) polypyridine complexes and its application in luminescent oxygen sensing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095158551424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular reaction to hypoxia: sensing and responding to an adverse environment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095624543616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interaction of oxygen-sensitive luminescent probes Ru(phen)32+ and Ru(bipy)32+ with animal and plant cells in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096197735168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia-Sensitive Fluorescent Probes for <i>in Vivo</i> Real-Time Fluorescence Imaging of Acute Ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640763862656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of hypoxia-sensitive Gd3+-based MRI contrast agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641814111360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A highly luminescent and highly oxygen-sensitive Tb(<scp>iii</scp>) complex with a tris-aryloxide functionalised 1,4,7-triazacyclononane ligand"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848654921750656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phosphorescent Ruthenium Complexes with a Nitroimidazole Unit that Image Oxygen Fluctuation in Tumor Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657245033856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxygen imaging of living cells and tissues using luminescent molecular probes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658050120320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Water-Soluble Phosphorescent Ruthenium Complex with a Fluorescent Coumarin Unit for Ratiometric Sensing of Oxygen Levels in Living Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658050299520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Confinement of Singlet Oxygen Generated from Ruthenium Complex-Based Oxygen Sensor in the Pores of Mesoporous Silica Nanoparticles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570030670592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Application of d6 transition metal complexes in fluorescence cell imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570171052800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual emission probe for luminescence oxygen sensing: a critical comparison between intensity, lifetime and ratiometric measurements"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131418418042496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044146201216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Emission under Hypoxia: One‐Electron Reduction and Fluorescence Characteristics of an Indolequinone–Coumarin Conjugate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520287136896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia — a key regulatory factor in tumour growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521086391040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversible triplet-triplet energy transfer within a covalently linked bichromophoric molecule"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468414783104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessing regional hypoxia in human renal tumours using\n                    <sup>18</sup>\n                    F‐fluoromisonidazole positron emission tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469895246208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469897088512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxygen distribution in murine tumors: characterization using oxygen-dependent quenching of phosphorescence"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471426350208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In Vivo Phosphorescence Imaging of <i>p</i>O<sub><b>2</b></sub> Using Planar Oxygen Sensors"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944985913600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphorescent Light–Emitting Iridium Complexes Serve as a Hypoxia-Sensing Probe for Tumor Imaging in Living Animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946108930304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru(dpp(SO3Na)2)3]Cl2"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368334994944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Excited-State Processes in Ruthenium(II) Bipyridine Complexes Containing Covalently Bound Arenes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843868877056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843966048640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Optical Imaging of Tumor Hypoxia and Evaluation of Efficacy of a Hypoxia-Targeting Drug in Living Animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318552166912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318817370240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual sensing of oxygen and temperature using quantum dots and a ruthenium complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793531947264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis, Characterization, and Evaluation of [Ir(ppy)<sub>2</sub>(vpy)Cl] as a Polymer-Bound Oxygen Sensor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794921255040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fluorescent markers for hypoxic cells: a study of nitroaromatic compounds, with fluorescent heterocyclic side chains, that undergo bioreductive binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795145203840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia Regulates Macrophage Functions in Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795550585600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796013964416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiogenesis Ischemic and Neoplastic Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269022870656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269321823872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A ruthenium(II) tris(2,2′-bipyridine) derivative possessing a triplet lifetime of 42 μs"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269336502016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Self-referenced RGB colour imaging of intracellular oxygen"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269656416000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Noninvasive imaging of the distribution in oxygen in tissue in vivo using near-infrared phosphors"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269661748736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel fluorescent oxygen indicator for intracellular oxygen measurements"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/chem.201202809"},{"@type":"KAKEN","@value":"PRODUCT-14341016"},{"@type":"KAKEN","@value":"PRODUCT-14370912"},{"@type":"KAKEN","@value":"PRODUCT-15022539"},{"@type":"OPENAIRE","@value":"doi_dedup___::cde0954ed89d5123db94f00eafaea02c"},{"@type":"CROSSREF","@value":"10.1002/cbic.201700116_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1002/cbic.201700685_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1039/d0ra08771h_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.3390/s150613503_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1002/cphc.201500793_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1021/acs.bioconjchem.5b00093_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1039/c4cc07717b_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1002/chem.201404979_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1021/ac5040067_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1039/c9ra00951e_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1021/acs.bioconjchem.8b00811_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2016.09.024_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"},{"@type":"CROSSREF","@value":"10.1016/j.jphotochemrev.2017.01.001_references_DOI_9eILzst2slrWFwMPYHuFS9cqQor"}]}