{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004230127042944.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/hep.26594"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.26594"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/01515467-201311000-00014"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title/>\n            <jats:p>\n                                 <jats:bold>Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty liver disease. Here we tested the hypothesis that fructose may interact with a high-fat diet to induce fatty liver, and to determine if this was dependent on a key enzyme in fructose metabolism, fructokinase. Wild-type or fructokinase knockout mice were fed a low-fat (11%), high-fat (36%), or high-fat (36%) and high-sucrose (30%) diet for 15 weeks. Both wild-type and fructokinase knockout mice developed obesity with mild hepatic steatosis and no evidence of hepatic inflammation on a high-fat diet compared to a low-fat diet. In contrast, wild-type mice fed a high-fat and high-sucrose diet developed more severe hepatic steatosis with low-grade inflammation and fibrosis, as noted by increased CD68, tumor necrosis factor alpha, monocyte chemoattractant protein-1, alpha-smooth muscle actin, and collagen I and TIMP1 expression. These changes were prevented in the fructokinase knockout mice.</jats:bold>\n                              </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:</jats:title>\n            <jats:p>\n                                 <jats:bold>An additive effect of high-fat and high-sucrose diet on the development of hepatic steatosis exists. Further, the combination of sucrose with high-fat diet may induce steatohepatitis. The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis. These studies emphasize the important role of fructose in the development of fatty liver and nonalcoholic steatohepatitis. (Hepatology 2013;58:1632–1643)</jats:bold>\n                              </jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004230127042561","@type":"Researcher","foaf:name":[{"@value":"Takuji Ishimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042573","@type":"Researcher","foaf:name":[{"@value":"Miguel A. Lanaspa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042946","@type":"Researcher","foaf:name":[{"@value":"Christopher J. Rivard"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042564","@type":"Researcher","foaf:name":[{"@value":"Carlos A. Roncal-Jimenez"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042817","@type":"Researcher","foaf:name":[{"@value":"David J. Orlicky"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042958","@type":"Researcher","foaf:name":[{"@value":"Christina Cicerchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042947","@type":"Researcher","foaf:name":[{"@value":"Rachel H. McMahan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042821","@type":"Researcher","foaf:name":[{"@value":"Manal F. Abdelmalek"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042575","@type":"Researcher","foaf:name":[{"@value":"Hugo R. Rosen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042948","@type":"Researcher","foaf:name":[{"@value":"Matthew R. Jackman"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042692","@type":"Researcher","foaf:name":[{"@value":"Paul S. MacLean"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042949","@type":"Researcher","foaf:name":[{"@value":"Christine P. Diggle"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042565","@type":"Researcher","foaf:name":[{"@value":"Aruna Asipu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042572","@type":"Researcher","foaf:name":[{"@value":"Shinichiro Inaba"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042574","@type":"Researcher","foaf:name":[{"@value":"Tomoki Kosugi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042688","@type":"Researcher","foaf:name":[{"@value":"Waichi Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042567","@type":"Researcher","foaf:name":[{"@value":"Shoichi Maruyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042576","@type":"Researcher","foaf:name":[{"@value":"Laura G. Sánchez-Lozada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042819","@type":"Researcher","foaf:name":[{"@value":"Yuri Y. Sautin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042562","@type":"Researcher","foaf:name":[{"@value":"James O. Hill"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042950","@type":"Researcher","foaf:name":[{"@value":"David T. Bonthron"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230127042957","@type":"Researcher","foaf:name":[{"@value":"Richard J. Johnson"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02709139"}],"prism:publicationName":[{"@value":"Hepatology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2013-11","prism:volume":"58","prism:number":"5","prism:startingPage":"1632","prism:endingPage":"1643"},"reviewed":"false","dc:rights":["http://doi.wiley.com/10.1002/tdm_license_1.1","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.26594"},{"@id":"https://journals.lww.com/01515467-201311000-00014"}],"createdAt":"2013-06-28","modifiedAt":"2024-12-01","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782189874816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24108008"},{"@type":"JGN","@value":"JP24108008"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24108008/"}],"notation":[{"@language":"ja","@value":"プラズマ医療科学の臨床応用論的学術基盤の構築と体系化"},{"@language":"en","@value":"Systematization and development of clinical applications for plasma medicine based on scientific infrastructure"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144248989568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stimulation of human purine synthesis de novo by fructose infusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870029762560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021396530143104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286993317118208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Saturated fatty acid is a principal 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Hypothesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519039035264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519667369088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased Fructose Consumption Is Associated With Fibrosis Severity in Patients With Nonalcoholic Fatty Liver Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520946415360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sugar Content of Popular Sweetened Beverages Based on Objective Laboratory Analysis: Focus on Fructose Content"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521105453824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Dietary Monosodium Glutamate on HFCS‐Induced Hepatic Steatosis: Expression Profiles in the Liver 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