{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004230161596544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/jcb.25228"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.25228"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.25228"}},{"identifier":{"@type":"PMID","@value":"25981537"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Involvement of PRIP (Phospholipase C‐Related But Catalytically Inactive Protein) in BMP‐Induced Smad Signaling in Osteoblast Differentiation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:label/><jats:p>Phospholipase C‐related but catalytically inactive protein (PRIP) was first isolated as an inositol 1,4,5‐trisphosphate binding protein. We generated PRIP gene‐deficient mice which exhibited the increased bone mineral density and trabecular bone volume, indicating that PRIP is implicated in the regulation of bone properties. In this study, we investigated the possible mechanisms by which PRIP plays a role in bone morphogenetic protein (BMP) signaling, by analyzing the culture of primary cells isolated from calvaria of two genotypes, the wild type and a mutant. In the mutant culture, enhanced osteoblast differentiation was observed by measuring alkaline phosphatase staining and activity. The promoter activity of Id1 gene, responding immediately to BMP, was also more increased. Smad1/5 phosphorylation in response to BMP showed an enhanced peak and was more persistent in mutant cells, but the dephosphorylation process was not different between the two genotypes. The luciferase assay using calvaria cells transfected with the Smad1 mutated as a constitutive active form showed increased transcriptional activity at similar levels between the genotypes. The expression of BMP receptors was not different between the genotypes. BMP‐induced phosphorylation of Smad1/5 was robustly decreased in wild type cells, but not in mutant cells, by pretreatment with DB867, an inhibitor of methyltransferase of inhibitory Smad6. Furthermore, BMP‐induced translocation of Smad6 from nucleus to cytosol was not much observed in PRIP‐deficient cells. These results indicate that PRIP is implicated in BMP‐induced osteoblast differentiation by the negative regulation of Smad phosphorylation, through the methylation of inhibitory Smad6. J. Cell. Biochem. 116: 2814–2823, 2015. © 2015 Wiley Periodicals, Inc.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004230161596289","@type":"Researcher","foaf:name":[{"@value":"Miho Kotani"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular and Cellular Biochemistry Faculty of Dental Science Kyushu University Fukuoka 812‐8582 Japan"},{"@value":"Division of Orthodontics Faculty of Dental Science Kyushu University Fukuoka 812‐8582 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230161596554","@type":"Researcher","foaf:name":[{"@value":"Miho Matsuda"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular and Cellular Biochemistry Faculty of Dental Science Kyushu University Fukuoka 812‐8582 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230161596544","@type":"Researcher","foaf:name":[{"@value":"Ayako Murakami"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular and Cellular Biochemistry Faculty of Dental Science Kyushu University Fukuoka 812‐8582 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230161596420","@type":"Researcher","foaf:name":[{"@value":"Ichiro Takahashi"}],"jpcoar:affiliationName":[{"@value":"Division of Orthodontics Faculty of Dental Science Kyushu University Fukuoka 812‐8582 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230161596426","@type":"Researcher","foaf:name":[{"@value":"Takenobu Katagiri"}],"jpcoar:affiliationName":[{"@value":"Division of Pathophysiology Research Center for Genomic Medicine Saitama Medical University Hidaka Saitama 350‐1241 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230161596673","@type":"Researcher","foaf:name":[{"@value":"Masato Hirata"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular and Cellular Biochemistry Faculty of Dental Science Kyushu University Fukuoka 812‐8582 Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07302312"},{"@type":"EISSN","@value":"10974644"}],"prism:publicationName":[{"@value":"Journal of Cellular Biochemistry"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-10-08","prism:volume":"116","prism:number":"12","prism:startingPage":"2814","prism:endingPage":"2823"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.25228"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.25228"}],"createdAt":"2015-05-18","modifiedAt":"2023-10-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Smad5%20Protein","dc:title":"Smad5 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Osteoblasts","dc:title":"Osteoblasts"},{"@id":"https://cir.nii.ac.jp/all?q=Smad6%20Protein","dc:title":"Smad6 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Receptor%20Coactivators","dc:title":"Nuclear Receptor Coactivators"},{"@id":"https://cir.nii.ac.jp/all?q=Primary%20Cell%20Culture","dc:title":"Primary Cell Culture"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Methylation","dc:title":"Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Smad1%20Protein","dc:title":"Smad1 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Osteogenesis","dc:title":"Osteogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Bone%20Morphogenetic%20Proteins","dc:title":"Bone Morphogenetic Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782192016512","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24229009"},{"@type":"JGN","@value":"JP24229009"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24229009/"}],"notation":[{"@language":"ja","@value":"骨・腸・代謝連関シグナルの解明と性差の明確化"},{"@language":"en","@value":"Analysis of the functional interaction among bone, gut and energy metabolism with a special reference to gender 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