{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004230187903232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/jmv.25434"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.25434"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25434"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.25434"}},{"identifier":{"@type":"PMID","@value":"30788852"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Attenuation of human herpesvirus 6B reactivation by aging"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>There has been little research on human herpesvirus 6B (HHV‐6B) in healthy adults and prevalences in different age groups have been unclear. Therefore, the major objective of this study was to evaluate seroprevalence to HHV‐6 antibodies in ordinary working people and examine the effect of aging on seroprevalence. Also, as HHV‐6B is reactivated in saliva, another objective was to investigate an association between age and HHV‐6B reactivation based on measured salivary HHV‐6 DNA levels.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Our subjects were 77 ordinary office workers who underwent a health checkup. In this population, we measured anti‐HHV‐6 antibody titers using enzyme‐linked immunosorbent assay and salivary HHV‐6 DNA levels. In addition to examining an association with age, we examined associations with body mass index, smoking habit, and alcohol consumption as confounding factors.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>There was a significant decrease in the seropositivity of HHV‐6 antibodies in subjects of 50 years and older, and age was significantly negatively correlated with anti‐HHV‐6 antibody titers. Age and salivary HHV‐6 DNA levels were also significantly negatively correlated but there were no significant correlations with other factors.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our results suggest that HHV‐6B reactivation is attenuated by aging. Thus, HHV‐6 antibodies steadily decrease in the body with aging.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326229418880","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20385321"},{"@type":"NRID","@value":"1000020385321"},{"@type":"NRID","@value":"9000324652402"},{"@type":"NRID","@value":"9000018671322"},{"@type":"NRID","@value":"9000398435729"},{"@type":"NRID","@value":"9000398421734"},{"@type":"NRID","@value":"9000398436974"},{"@type":"NRID","@value":"9000243890896"},{"@type":"NRID","@value":"9000023471775"},{"@type":"NRID","@value":"9000380433326"},{"@type":"NRID","@value":"9000006099675"},{"@type":"NRID","@value":"9000398429928"},{"@type":"NRID","@value":"9000398443350"},{"@type":"NRID","@value":"9000398443370"},{"@type":"NRID","@value":"9000002261824"},{"@type":"NRID","@value":"9000256590975"},{"@type":"NRID","@value":"9000253557570"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nkoba"}],"foaf:name":[{"@value":"Nobuyuki Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Department of Virology The Jikei University School of Medicine Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230187903235","@type":"Researcher","foaf:name":[{"@value":"Toshiko Nishiyama"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health and Environmental Medicine The Jikei University School of Medicine Tokyo Japan"},{"@value":"Department of Internal Medicine Otemachi Sakura Clinic in Toyosu Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230187903236","@type":"Researcher","foaf:name":[{"@value":"Takashi Yamauchi"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health and Environmental Medicine The Jikei University School of Medicine Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230187903108","@type":"Researcher","foaf:name":[{"@value":"Kazuya Shimada"}],"jpcoar:affiliationName":[{"@value":"Department of Virology The Jikei University School of Medicine Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230187903105","@type":"Researcher","foaf:name":[{"@value":"Machi Suka"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health and Environmental Medicine The Jikei University School of Medicine Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230187903234","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro Kondo"}],"jpcoar:affiliationName":[{"@value":"Department of Virology The Jikei University School of Medicine Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004230187903106","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Yanagisawa"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health and Environmental Medicine The Jikei University School of Medicine Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01466615"},{"@type":"EISSN","@value":"10969071"}],"prism:publicationName":[{"@value":"Journal of Medical Virology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-02-27","prism:volume":"91","prism:number":"7","prism:startingPage":"1335","prism:endingPage":"1341"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.25434"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25434"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.25434"}],"createdAt":"2019-02-21","modifiedAt":"2023-09-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Aging","dc:title":"Aging"},{"@id":"https://cir.nii.ac.jp/all?q=Herpesvirus%206,%20Human","dc:title":"Herpesvirus 6, Human"},{"@id":"https://cir.nii.ac.jp/all?q=Roseolovirus%20Infections","dc:title":"Roseolovirus Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Antibodies,%20Viral","dc:title":"Antibodies, Viral"},{"@id":"https://cir.nii.ac.jp/all?q=Young%20Adult","dc:title":"Young Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Seroepidemiologic%20Studies","dc:title":"Seroepidemiologic Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Virus%20Activation","dc:title":"Virus 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