{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004230822226304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/978-4-431-55561-2_18"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/978-4-431-55561-2_18"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004230822226052","@type":"Researcher","foaf:name":[{"@value":"Takeshi Endo"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276187443200","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60466860"},{"@type":"NRID","@value":"1000060466860"},{"@type":"NRID","@value":"9000019985468"},{"@type":"NRID","@value":"9000002492604"},{"@type":"NRID","@value":"9000254573724"},{"@type":"NRID","@value":"9000254141925"},{"@type":"NRID","@value":"9000283255458"},{"@type":"NRID","@value":"9000257830127"},{"@type":"NRID","@value":"9000010173061"},{"@type":"NRID","@value":"9000000286005"},{"@type":"NRID","@value":"9000016894533"},{"@type":"NRID","@value":"9000319559564"},{"@type":"NRID","@value":"9000264271704"},{"@type":"NRID","@value":"9000000289830"},{"@type":"NRID","@value":"9000254574208"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kazunori_takano"}],"foaf:name":[{"@value":"Kazunori Takano"}]}],"publication":{"publicationIdentifier":[{"@type":"ISBN","@value":"9784431555605"},{"@type":"ISBN","@value":"9784431555612"}],"prism:publicationName":[{"@value":"Protein Modifications in Pathogenic Dysregulation of Signaling"}],"dc:publisher":[{"@value":"Springer Japan"}],"prism:publicationDate":"2015","prism:startingPage":"287","prism:endingPage":"307"},"reviewed":"false","dc:rights":["https://www.springernature.com/gp/researchers/text-and-data-mining","https://www.springernature.com/gp/researchers/text-and-data-mining"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1007/978-4-431-55561-2_18"}],"createdAt":"2015-09-01","modifiedAt":"2023-02-10","project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257276877440","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26440045"},{"@type":"JGN","@value":"JP26440045"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26440045/"}],"notation":[{"@language":"ja","@value":"心筋肥大におけるN-WASP-Nebl複合体の活性化制御機構の解明"},{"@language":"en","@value":"Elucidation of the mechanism of N-WASP-Nebl complex activation during cardiomyocyte hypertrophy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219092351360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146159143552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Filopodia: Complex models for simple rods"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693414926848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nebulin and N-WASP Cooperate to Cause IGF-1–Induced Sarcomeric Actin Filament Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619423244160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The many faces of actin: matching assembly factors with cellular structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621608498048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Filopodia initiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092888884096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Insulin and insulin-like growth factor signalling in neoplasia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093946307328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytoneme-mediated cell-to-cell signaling during development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096161945088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Life at the Leading Edge"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096247326080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ARP2/3 complex: an actin nucleator comes of age"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659426286208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569251960832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Specificity of\n                    <i>Drosophila</i>\n                    Cytonemes for Distinct Signaling Pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570470255360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"mTOR Signaling in Growth Control and Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570747508096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thin filament length regulation in striated muscle sarcomeres: Pointed-end dynamics go beyond a nebulin ruler"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044188915456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of 45 novel mutations in the nebulin gene associated with autosomal recessive nemaline myopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044271875072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044444746880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytoneme-Mediated Contact-Dependent Transport of the\n                    <i>Drosophila</i>\n                    Decapentaplegic Signaling Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519837800064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stem Cells and Plasticity of Skeletal Muscle Cell Differentiation: Potential Application to Cell Therapy for Degenerative Muscular Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520353737216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A nucleator arms race: cellular control of actin assembly"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520586911488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nebulin regulates thin filament length, contractility, and Z‐disk structure in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520629586560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The WASP–WAVE protein network: connecting the membrane to the cytoskeleton"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993682739072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995907357440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Actin filament nucleation and elongation factors – structure–function relationships"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468846385920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469115048448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of formins in filopodia formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471037383808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the Rho'd: The regulation of membrane protrusions by Rho‐GTPases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471451206528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nemaline Myopathies"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945353529728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nebulin, a major player in muscle health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418298147712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"N-WASP and WAVE2 Acting Downstream of Phosphatidylinositol 3-Kinase Are Required for Myogenic Cell Migration Induced by Hepatocyte Growth Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419398527488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420222450688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Actin nucleation and elongation factors: mechanisms and interplay"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420312046976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Small GTPase RhoD suppresses cell migration and cytokinesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420350279424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytonemes as specialized signaling filopodia"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893793364224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894134031872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: Membrane Nanotubes Connect Immune Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894262663808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894729750656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368453579392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular and Molecular Regulation of Muscle Regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370078642688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-distance electrical coupling via tunneling nanotubes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370085058944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nanotubular Highways for Intercellular Organelle Transport"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370184369664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dilated cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843978418432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytonemes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844168124544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endosome dynamics regulated by a Rho protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319861690496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Filopodia: molecular architecture and cellular functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319927543936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Membrane nanotubes: dynamic long-distance connections between animal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319937899264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Satellite Cells and the Muscle Stem Cell Niche"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320034606208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Insulin-like Growth Factor-Phosphatidylinositol 3-Kinase-Akt Signaling Pathway Regulates Myogenin Expression in Normal Myogenic Cells but Not in Rhabdomyosarcoma-derived RD Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320347912576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321081411968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FoxO3 Controls Autophagy in Skeletal Muscle In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321219908736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795521773056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269238337152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unleashing formins to remodel the actin and microtubule cytoskeletons"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269295995776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269298938496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leiomodin Is an Actin Filament Nucleator in Muscle Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270630476672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular mechanisms of cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270720308224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A two-segment model for thin filament architecture in skeletal muscle"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/978-4-431-55561-2_18"},{"@type":"KAKEN","@value":"PRODUCT-20252050"}]}