{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004231169924864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00204-012-0865-8"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00204-012-0865-8.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s00204-012-0865-8/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00204-012-0865-8"}},{"identifier":{"@type":"PMID","@value":"22576464"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats"}],"description":[{"notation":[{"@value":"Estragole (ES) is a natural organic compound used frequently as a flavoring food additive. Although it has been reported to be tumorigenic and induce DNA adducts in the mouse liver, there have been no reports regarding ES hepatocarcinogenicity in rats. In the current study, we therefore examined potent carcinogenicity, DNA adduct formation and in vivo genotoxicity of ES in the livers of wild and reporter gene-carrying F344 rats. Males were administered 600 mg/kg bw ES by gavage and sequentially sacrificed at weeks 4, 8 and 16 for GST-P and PCNA immunohistochemistry and measurement of ES-specific DNA adducts by LC-MS/MS in the livers. GST-P-positive foci increased with time in ES-treated rats from week 4, PCNA-labeling indices being similarly elevated at both weeks 4 and 8. ES-specific DNA adducts such as ES-3'-N(2)-dG, 3'-8-dG and 3'-N(6)-dA were consistently detected, particularly at week 4. In a second study, male F344 gpt delta rats were administered 0, 22, 66, 200 or 600 mg/kg bw ES for 4 weeks. Gpt mutant frequency in the liver was increased in a dose-dependent manner, with significance at 200 and 600 mg/kg bw in good correlation with PCNA-labeling indices. Mutation spectra analysis showed A:T to G:C transitions to be predominantly increased in line with the formation of ES-3'-N(6)-dA or 3'-8-dG. These results indicate that ES could be a possible genotoxic hepatocarcinogen in the rat, at least when given at high doses."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004231169924867","@type":"Researcher","foaf:name":[{"@value":"Yuta Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169925130","@type":"Researcher","foaf:name":[{"@value":"Takashi Umemura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169925250","@type":"Researcher","foaf:name":[{"@value":"Daisuke Hibi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169924865","@type":"Researcher","foaf:name":[{"@value":"Tomoki Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169924998","@type":"Researcher","foaf:name":[{"@value":"Meilan Jin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169924994","@type":"Researcher","foaf:name":[{"@value":"Yuji Ishii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169924866","@type":"Researcher","foaf:name":[{"@value":"Hiroki Sakai"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801206865536","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30150890"},{"@type":"NRID","@value":"1000030150890"},{"@type":"NRID","@value":"9000363398435"},{"@type":"NRID","@value":"9000014340620"},{"@type":"NRID","@value":"9000363398785"},{"@type":"NRID","@value":"9000363398968"},{"@type":"NRID","@value":"9000363398935"},{"@type":"NRID","@value":"9000363399053"},{"@type":"NRID","@value":"9000363399034"},{"@type":"NRID","@value":"9000317127165"},{"@type":"NRID","@value":"9000317128300"},{"@type":"NRID","@value":"9000363399429"},{"@type":"NRID","@value":"9000363399437"},{"@type":"NRID","@value":"9000254221820"},{"@type":"NRID","@value":"9000391983704"},{"@type":"NRID","@value":"9000001968711"},{"@type":"NRID","@value":"9000363398432"},{"@type":"NRID","@value":"9000363398628"},{"@type":"NRID","@value":"9000363398694"},{"@type":"NRID","@value":"9000363398858"},{"@type":"NRID","@value":"9000363398746"},{"@type":"NRID","@value":"9000363398531"},{"@type":"NRID","@value":"9000363399632"},{"@type":"NRID","@value":"9000363399208"},{"@type":"NRID","@value":"9000242883002"},{"@type":"NRID","@value":"9000242883040"},{"@type":"NRID","@value":"9000347050001"},{"@type":"NRID","@value":"9000392751715"},{"@type":"NRID","@value":"9000257967366"},{"@type":"NRID","@value":"9000257967071"},{"@type":"NRID","@value":"9000020773577"},{"@type":"NRID","@value":"9000363398501"},{"@type":"NRID","@value":"9000363398747"},{"@type":"NRID","@value":"9000005839037"},{"@type":"NRID","@value":"9000363399370"},{"@type":"NRID","@value":"9000364830761"},{"@type":"NRID","@value":"9000363399052"},{"@type":"NRID","@value":"9000391979682"},{"@type":"NRID","@value":"9000386309467"},{"@type":"NRID","@value":"9000253401422"},{"@type":"NRID","@value":"9000391994898"},{"@type":"NRID","@value":"9000391992386"},{"@type":"NRID","@value":"9000020768626"},{"@type":"NRID","@value":"9000363398631"},{"@type":"NRID","@value":"9000363398691"},{"@type":"NRID","@value":"9000363398525"},{"@type":"NRID","@value":"9000363398995"},{"@type":"NRID","@value":"9000317128093"},{"@type":"NRID","@value":"9000363399172"},{"@type":"NRID","@value":"9000363399482"},{"@type":"NRID","@value":"9000240184757"},{"@type":"NRID","@value":"9000347140708"},{"@type":"NRID","@value":"9000392748100"},{"@type":"NRID","@value":"9000391998092"},{"@type":"NRID","@value":"9000258714186"},{"@type":"NRID","@value":"9000363398734"},{"@type":"NRID","@value":"9000363398538"},{"@type":"NRID","@value":"9000363399365"},{"@type":"NRID","@value":"9000363399364"},{"@type":"NRID","@value":"9000363399340"},{"@type":"NRID","@value":"9000317127645"},{"@type":"NRID","@value":"9000006861081"},{"@type":"NRID","@value":"9000242883291"},{"@type":"NRID","@value":"9000240043071"},{"@type":"NRID","@value":"9000255860493"},{"@type":"NRID","@value":"9000257967050"},{"@type":"NRID","@value":"9000006138951"},{"@type":"NRID","@value":"9000248248079"},{"@type":"NRID","@value":"9000363398624"},{"@type":"NRID","@value":"9000363399381"},{"@type":"NRID","@value":"9000363399350"},{"@type":"NRID","@value":"9000318587631"},{"@type":"NRID","@value":"9000411486840"},{"@type":"NRID","@value":"9000391993725"},{"@type":"NRID","@value":"9000391994057"},{"@type":"NRID","@value":"9000257967340"},{"@type":"NRID","@value":"9000363398629"},{"@type":"NRID","@value":"9000363398677"},{"@type":"NRID","@value":"9000363398865"},{"@type":"NRID","@value":"9000363398887"},{"@type":"NRID","@value":"9000363398784"},{"@type":"NRID","@value":"9000364812446"},{"@type":"NRID","@value":"9000363399154"},{"@type":"NRID","@value":"9000363399118"},{"@type":"NRID","@value":"9000006861072"},{"@type":"NRID","@value":"9000391987044"},{"@type":"NRID","@value":"9000257946554"},{"@type":"NRID","@value":"9000005178399"},{"@type":"NRID","@value":"9000008108901"},{"@type":"NRID","@value":"9000363398596"},{"@type":"NRID","@value":"9000363398853"},{"@type":"NRID","@value":"9000363398731"},{"@type":"NRID","@value":"9000363398537"},{"@type":"NRID","@value":"9000006169588"},{"@type":"NRID","@value":"9000363398928"},{"@type":"NRID","@value":"9000317127733"},{"@type":"NRID","@value":"9000363399064"},{"@type":"NRID","@value":"9000347047365"},{"@type":"NRID","@value":"9000008418538"},{"@type":"NRID","@value":"9000363398452"},{"@type":"NRID","@value":"9000363398791"},{"@type":"NRID","@value":"9000363399351"},{"@type":"NRID","@value":"9000363398953"},{"@type":"NRID","@value":"9000363399452"},{"@type":"NRID","@value":"9000391994889"},{"@type":"NRID","@value":"9000391993128"},{"@type":"NRID","@value":"9000391993172"},{"@type":"NRID","@value":"9000391998370"},{"@type":"NRID","@value":"9000001603435"},{"@type":"NRID","@value":"9000363398611"},{"@type":"NRID","@value":"9000363398863"},{"@type":"NRID","@value":"9000363399366"},{"@type":"NRID","@value":"9000363398941"},{"@type":"NRID","@value":"9000363399253"},{"@type":"NRID","@value":"9000363399174"},{"@type":"NRID","@value":"9000363399104"},{"@type":"NRID","@value":"9000363399114"},{"@type":"NRID","@value":"9000347049880"},{"@type":"NRID","@value":"9000391993163"},{"@type":"NRID","@value":"9000391986048"},{"@type":"NRID","@value":"9000391981251"},{"@type":"NRID","@value":"9000283280656"},{"@type":"NRID","@value":"9000257967245"},{"@type":"NRID","@value":"9000257967182"},{"@type":"NRID","@value":"9000363398983"},{"@type":"NRID","@value":"9000363399327"},{"@type":"NRID","@value":"9000363399271"},{"@type":"NRID","@value":"9000363399480"},{"@type":"NRID","@value":"9000240184363"},{"@type":"NRID","@value":"9000363399532"},{"@type":"NRID","@value":"9000363399577"},{"@type":"NRID","@value":"9000391977642"},{"@type":"NRID","@value":"9000347192478"},{"@type":"NRID","@value":"9000257967357"},{"@type":"NRID","@value":"9000257967183"},{"@type":"NRID","@value":"9000010175257"},{"@type":"NRID","@value":"9000363398789"},{"@type":"NRID","@value":"9000363398864"},{"@type":"NRID","@value":"9000363399338"},{"@type":"NRID","@value":"9000363398987"},{"@type":"NRID","@value":"9000363399016"},{"@type":"NRID","@value":"9000006513485"},{"@type":"NRID","@value":"9000363249991"},{"@type":"NRID","@value":"9000363399328"},{"@type":"NRID","@value":"9000391983947"},{"@type":"NRID","@value":"9000363398450"},{"@type":"NRID","@value":"9000363398743"},{"@type":"NRID","@value":"9000364833509"},{"@type":"NRID","@value":"9000363398920"},{"@type":"NRID","@value":"9000317127494"},{"@type":"NRID","@value":"9000363399217"},{"@type":"NRID","@value":"9000363399177"},{"@type":"NRID","@value":"9000363399454"},{"@type":"NRID","@value":"9000363399458"},{"@type":"NRID","@value":"9000391980442"},{"@type":"NRID","@value":"9000391997704"},{"@type":"NRID","@value":"9000391986490"},{"@type":"NRID","@value":"9000363398627"},{"@type":"NRID","@value":"9000363398539"},{"@type":"NRID","@value":"9000363399385"},{"@type":"NRID","@value":"9000364829338"},{"@type":"NRID","@value":"9000363399033"},{"@type":"NRID","@value":"9000317127223"},{"@type":"NRID","@value":"9000317127504"},{"@type":"NRID","@value":"9000363399199"},{"@type":"NRID","@value":"9000363399146"},{"@type":"NRID","@value":"9000363399276"},{"@type":"NRID","@value":"9000363399557"},{"@type":"NRID","@value":"9000242883283"},{"@type":"NRID","@value":"9000391978449"},{"@type":"NRID","@value":"9000386308526"},{"@type":"NRID","@value":"9000391998390"},{"@type":"NRID","@value":"9000363398434"},{"@type":"NRID","@value":"9000363398630"},{"@type":"NRID","@value":"9000398127915"},{"@type":"NRID","@value":"9000363398778"},{"@type":"NRID","@value":"9000005838494"},{"@type":"NRID","@value":"9000363399415"},{"@type":"NRID","@value":"9000364822814"},{"@type":"NRID","@value":"9000363398956"},{"@type":"NRID","@value":"9000006939420"},{"@type":"NRID","@value":"9000363399432"},{"@type":"NRID","@value":"9000254693638"},{"@type":"NRID","@value":"9000363398914"},{"@type":"NRID","@value":"9000363399640"},{"@type":"NRID","@value":"9000363399124"},{"@type":"NRID","@value":"9000363399457"},{"@type":"NRID","@value":"9000363399451"},{"@type":"NRID","@value":"9000363399483"},{"@type":"NRID","@value":"9000392001107"},{"@type":"NRID","@value":"9000398127947"},{"@type":"NRID","@value":"9000398127659"},{"@type":"NRID","@value":"9000398127661"},{"@type":"NRID","@value":"9000398127927"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0003923"}],"foaf:name":[{"@value":"Takehiko Nohmi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169924996","@type":"Researcher","foaf:name":[{"@value":"Tokuma Yanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169924868","@type":"Researcher","foaf:name":[{"@value":"Akiyoshi Nishikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231169925124","@type":"Researcher","foaf:name":[{"@value":"Kumiko Ogawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03405761"},{"@type":"EISSN","@value":"14320738"}],"prism:publicationName":[{"@value":"Archives of Toxicology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2012-05-11","prism:volume":"86","prism:number":"10","prism:startingPage":"1593","prism:endingPage":"1601"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s00204-012-0865-8.pdf"},{"@id":"http://link.springer.com/article/10.1007/s00204-012-0865-8/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s00204-012-0865-8"}],"createdAt":"2012-05-10","modifiedAt":"2019-05-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20Neoplasms","dc:title":"Liver Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Allylbenzene%20Derivatives","dc:title":"Allylbenzene Derivatives"},{"@id":"https://cir.nii.ac.jp/all?q=Anisoles","dc:title":"Anisoles"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Inbred%20F344","dc:title":"Rats, Inbred F344"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Flavoring%20Agents","dc:title":"Flavoring Agents"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Adducts","dc:title":"DNA Adducts"},{"@id":"https://cir.nii.ac.jp/all?q=Glutathione%20S-Transferase%20pi","dc:title":"Glutathione S-Transferase pi"},{"@id":"https://cir.nii.ac.jp/all?q=Tandem%20Mass%20Spectrometry","dc:title":"Tandem Mass Spectrometry"},{"@id":"https://cir.nii.ac.jp/all?q=Proliferating%20Cell%20Nuclear%20Antigen","dc:title":"Proliferating Cell Nuclear Antigen"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatography,%20Liquid","dc:title":"Chromatography, Liquid"},{"@id":"https://cir.nii.ac.jp/all?q=Mutagens","dc:title":"Mutagens"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257081131136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22241016"},{"@type":"JGN","@value":"JP22241016"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22241016/"}],"notation":[{"@language":"ja","@value":"ＤＮＡポリメラーゼζ（ゼータ）の遺伝的改変による遺伝毒性閾値形成機構に関する研究"},{"@language":"en","@value":"Studies on mechanisms underlying genotoxic thresholds through genetic modification of DNA polymerase zeta"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004240260659200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Thresholds of Genotoxic and Non-Genotoxic Carcinogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146082557184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats—an approach for a new medium-term bioassay system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706152890496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Combined application of comprehensive analysis for DNA modification and reporter gene mutation assay to evaluate kidneys of gpt delta rats given madder color or its constituents"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707357219200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708230863360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection and Quantification of Specific DNA Adducts by Liquid Chromatography−Tandem Mass Spectrometry in the Livers of Rats Given Estragole at the Carcinogenic Dose"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621278252160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Risk assessment of consumption of methylchavicol and tarragon: The genotoxic potential in vivo and in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184718438144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"In Vivo Genotoxicity of Methyleugenol in gpt Delta Transgenic Rats Following Medium-Term Exposure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093622738944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Safety assessment of allylalkoxybenzene derivatives used as flavouring substances — methyl eugenol and estragole"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094739837568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recent advances in the protocols of transgenic mouse mutation assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659596552064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569210006400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tandem Mass Spectrometry Analysis of <i>N</i><sup>2</sup>-(<i>trans</i>-Isoestragol-3‘-yl)-2‘-deoxyguanosine as a Strategy to Study Species Differences in Sulfotransferase Conversion of the Proximate Carcinogen 1‘-Hydroxyestragole"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593744667520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043824457344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo mutational analysis of liver DNA in <i>gpt</i> delta transgenic rats treated with the hepatocarcinogens <i>N</i>‐nitrosopyrrolidine, 2‐amino‐3‐methylimidazo[4,5‐<i>f</i>]quinoline, and di(2‐ethylhexyl)phthalate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518898694272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519277783424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470680881920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419113835264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Flavonoids and alkenylbenzenes: Mechanisms of mutagenic action and carcinogenic risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893986402176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The mutagenicities of safrole, estragole, eugenol, trans-anethole, and some of their known or possible metabolites for Salmonella typhimurium mutants"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895662515456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genotoxicity of safrole-related chemicals in microbial test systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368831730304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370327620608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Salmonella Mutagenicity tests: III. Results from the testing of 255 chemicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846363211264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<sup>32</sup>P-Post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F<sub>1</sub> mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793626197120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<sup>32</sup>P-Post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794079032192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795308244864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hepatocarcinogenicity of Estragole (1-Allyl-4-methoxybenzene) and 1′-Hydroxyestragole in the Mouse and Mutagenicity of 1′-Acetoxyestragole in Bacteria\n            2"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269968802432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of DNA adducts and mutations in spleen, liver and lung of XPA- deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204413768832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of a Medium-term Animal Model Using <i>gpt</i> Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity"},{"@value":"Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257000704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of DNA Lesions on Transcription Elongation by RNA Polymerases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205510792704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Past, Present and Future Directions of <i>gpt</i> delta Rodent Gene Mutation Assays"},{"@value":"Past, present and future directions of gpt delta rodent gene mutation assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680233639808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680234291840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Existence of a Threshold for the Genotoxic Carcinogens: Evidence from Mechanism-based Carcinogenicity Studies"},{"@value":"Wanibuchi, Existence of a threshold for the genotoxic carcinogens: evidence from mechanism-based carcinogenicity studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680487326080","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Carcinogenicity Assessment for Risk Factors in Food:"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680488218368","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Possible Carcinogenic Mechanisms Underlying Renal Carcinogens in          Food"}]},{"@id":"https://cir.nii.ac.jp/crid/2051714791867900032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transgenic rat models for mutagenesis and carcinogenesis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s00204-012-0865-8"},{"@type":"KAKEN","@value":"PRODUCT-13204642"},{"@type":"OPENAIRE","@value":"doi_dedup___::5b06655e67a90749d8b41cf064840b01"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0072-6_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.5487/tr.2018.34.4.281_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.1007/s00216-014-7621-2_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.14252/foodsafetyfscj.2014015_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.1093/toxsci/kfs294_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.14252/foodsafetyfscj.2013001_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.1093/mutage/geu018_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.1093/mutage/geab007_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.14252/foodsafetyfscj.2015024_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.1016/j.mrgentox.2012.07.002_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"},{"@type":"CROSSREF","@value":"10.1293/tox.26.19_references_DOI_AYqstV2N1ybJPQmTyPTLDjk1XoV"}]}