{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004231237471872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00424-014-1527-x"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00424-014-1527-x.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s00424-014-1527-x/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00424-014-1527-x"}},{"identifier":{"@type":"PMID","@value":"24797147"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Current understanding of sarcopenia: possible candidates modulating muscle mass"}],"description":[{"notation":[{"@value":"The world's elderly population is expanding rapidly, and we are now faced with the significant challenge of maintaining or improving physical activity, independence, and quality of life in the elderly. Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and often, frailty. Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, the mechanisms responsible for these deleterious changes present numerous therapeutic targets for drug discovery. Muscle loss has been linked with several proteolytic systems, including the ubuiquitin-proteasome, lysosome-autophagy, and tumor necrosis factor (TNF)-α/nuclear factor-kappaB (NF-κB) systems. Although many factors are considered to regulate age-dependent muscle loss, this gentle atrophy is not affected by factors known to enhance rapid atrophy (denervation, hindlimb suspension, etc.). In addition, defects in Akt-mammalian target of rapamycin (mTOR) and serum response factor (SRF)-dependent signaling have been found in sarcopenic muscle. Intriguingly, more recent studies indicated an apparent functional defect in autophagy- and myostatin-dependent signaling in sarcopenic muscle. In this review, we summarize the current understanding of the adaptation of many regulators in sarcopenia."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751163782784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60291176"},{"@type":"NRID","@value":"1000060291176"},{"@type":"CINII_AUTHOR_ID","@value":"DA18805747"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA18805747#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA18805747"},{"@type":"NRID","@value":"9000003202979"},{"@type":"NRID","@value":"9000006254871"},{"@type":"NRID","@value":"9000018321076"},{"@type":"NRID","@value":"9000003208723"},{"@type":"NRID","@value":"9000001696556"},{"@type":"NRID","@value":"9000002873662"},{"@type":"NRID","@value":"9000363374405"},{"@type":"NRID","@value":"9000363377907"},{"@type":"NRID","@value":"9000363373780"},{"@type":"NRID","@value":"9000283506608"},{"@type":"NRID","@value":"9000409888874"},{"@type":"NRID","@value":"9000363372214"},{"@type":"NRID","@value":"9000321623544"},{"@type":"NRID","@value":"9000363381438"},{"@type":"NRID","@value":"9000321623929"},{"@type":"NRID","@value":"9000283506563"},{"@type":"NRID","@value":"9000243891065"},{"@type":"NRID","@value":"9000380133423"},{"@type":"NRID","@value":"9000363379486"},{"@type":"NRID","@value":"9000021282730"},{"@type":"NRID","@value":"9000321623335"},{"@type":"NRID","@value":"9000402907331"},{"@type":"NRID","@value":"9000340440762"},{"@type":"NRID","@value":"9000020727508"},{"@type":"NRID","@value":"9000276435452"},{"@type":"NRID","@value":"9000259327400"},{"@type":"NRID","@value":"9000363376977"},{"@type":"NRID","@value":"9000363379494"},{"@type":"NRID","@value":"9000363381902"},{"@type":"NRID","@value":"9000321623414"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0209358"}],"foaf:name":[{"@value":"Kunihiro Sakuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231237471616","@type":"Researcher","foaf:name":[{"@value":"Wataru Aoi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004231237471622","@type":"Researcher","foaf:name":[{"@value":"Akihiko Yamaguchi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00316768"},{"@type":"EISSN","@value":"14322013"}],"prism:publicationName":[{"@value":"Pflügers Archiv - European Journal of Physiology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2014-05-07","prism:volume":"467","prism:number":"2","prism:startingPage":"213","prism:endingPage":"229"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s00424-014-1527-x.pdf"},{"@id":"http://link.springer.com/article/10.1007/s00424-014-1527-x/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s00424-014-1527-x"}],"createdAt":"2014-05-06","modifiedAt":"2025-05-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Aging","dc:title":"Aging"},{"@id":"https://cir.nii.ac.jp/all?q=Sarcopenia","dc:title":"Sarcopenia"},{"@id":"https://cir.nii.ac.jp/all?q=Serum%20Response%20Factor","dc:title":"Serum Response Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Myostatin","dc:title":"Myostatin"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy","dc:title":"Autophagy"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Ubiquitins","dc:title":"Ubiquitins"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782155640320","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23500778"},{"@type":"JGN","@value":"JP23500778"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500778/"}],"notation":[{"@language":"ja","@value":"オートファジーによるタンパク分解は、加齢性筋肉減弱症を誘発するか？"},{"@language":"en","@value":"Does protein degradation by autophagy induce sarcopenia?"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782293004160","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26350815"},{"@type":"JGN","@value":"JP26350815"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26350815/"}],"notation":[{"@language":"ja","@value":"加齢性筋減弱症における小胞体ストレスとオートファジーの役割の解明"},{"@language":"en","@value":"Elucidation of the functional role of endoplasmic reticulum stress and autophagy for sarcopenia"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215923918976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of MAFbx as a myogenin‐engaged F‐box protein in SCF ubiquitin ligase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230168735744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"p62/SQSTM1 but not LC3 is accumulated in sarcopenic 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