{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004231995694976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbamcr.2015.09.009"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S016748891500302X?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S016748891500302X?httpAccept=text/xml"}},{"identifier":{"@type":"PMID","@value":"26376412"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78"}],"description":[{"notation":[{"@value":"Insulin resistance is characterized as a pathogenic factor in type 2 diabetes. Despite skeletal muscle being primarily responsible for systemic glucose disposal, the mechanisms underlying the induction of insulin resistance in skeletal muscle have not been fully elucidated. A number of studies have shown that it is characterized by the inhibition of the phosphatidylinositol (PI) 3-kinase signaling pathway. Here, we show that skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP), a phosphatidylinositol-3,4,5-trisphosphate (PIP3) phosphatase, and glucose-regulated protein 78 (GRP78) are implicated in the inhibition of insulin-dependent PI 3-kinase signaling in skeletal muscle. Mechanistically, under resting conditions, SKIP forms a complex with GRP78 at the endoplasmic reticulum (ER). Insulin stimulation facilitates the dissociation of SKIP from GRP78 and its binding to the activated form of Pak1. GRP78 is necessary for membrane localization and Pak1-binding of SKIP, which facilitates inactivation of the insulin signaling pathway. These findings underscore the specific and prominent role of SKIP and GRP78 in the regulation of insulin-dependent PI 3-kinase signaling in skeletal muscle."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658556310146","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00361626"},{"@type":"NRID","@value":"1000000361626"},{"@type":"NRID","@value":"9000359946764"},{"@type":"NRID","@value":"9000001294115"},{"@type":"NRID","@value":"9000008109723"},{"@type":"NRID","@value":"9000399770086"},{"@type":"NRID","@value":"9000406059033"},{"@type":"NRID","@value":"9000411761091"},{"@type":"NRID","@value":"9000001901673"},{"@type":"NRID","@value":"9000336038144"},{"@type":"NRID","@value":"9000399770095"},{"@type":"NRID","@value":"9000011270899"},{"@type":"NRID","@value":"9000329009118"},{"@type":"NRID","@value":"9000380461698"},{"@type":"NRID","@value":"9000414837985"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0057142"}],"foaf:name":[{"@value":"Takeshi Ijuin"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658575904258","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10332280"},{"@type":"NRID","@value":"1000010332280"},{"@type":"NRID","@value":"9000017408945"},{"@type":"NRID","@value":"9000412274392"},{"@type":"NRID","@value":"9000387919095"},{"@type":"NRID","@value":"9000401955792"},{"@type":"NRID","@value":"9000006473714"},{"@type":"NRID","@value":"9000018561949"},{"@type":"NRID","@value":"9000004187710"},{"@type":"NRID","@value":"9000006331077"},{"@type":"NRID","@value":"9000411587965"},{"@type":"NRID","@value":"9000004121708"},{"@type":"NRID","@value":"9000412147007"},{"@type":"NRID","@value":"9000392134159"},{"@type":"NRID","@value":"9000019065721"},{"@type":"NRID","@value":"9000401545040"},{"@type":"NRID","@value":"9000259342046"},{"@type":"NRID","@value":"9000401962376"},{"@type":"NRID","@value":"9000017714377"},{"@type":"NRID","@value":"9000412185276"},{"@type":"NRID","@value":"9000391956492"},{"@type":"NRID","@value":"9000392136858"},{"@type":"NRID","@value":"9000324998542"},{"@type":"NRID","@value":"9000005054670"},{"@type":"NRID","@value":"9000406195229"},{"@type":"NRID","@value":"9000327102591"},{"@type":"NRID","@value":"9000409900755"},{"@type":"NRID","@value":"9000396164359"},{"@type":"NRID","@value":"9000380123403"},{"@type":"NRID","@value":"9000403272750"},{"@type":"NRID","@value":"9000398650152"},{"@type":"NRID","@value":"9000253177436"},{"@type":"NRID","@value":"9000239608276"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0212191"}],"foaf:name":[{"@value":"Naoya Hatano"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801210836096","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60590594"},{"@type":"NRID","@value":"1000060590594"},{"@type":"NRID","@value":"9000327102555"},{"@type":"NRID","@value":"9000004038416"},{"@type":"NRID","@value":"9000238258230"},{"@type":"NRID","@value":"9000255854333"},{"@type":"NRID","@value":"9000415083251"},{"@type":"NRID","@value":"9000006679384"},{"@type":"NRID","@value":"9000001008306"},{"@type":"NRID","@value":"9000414838007"},{"@type":"NRID","@value":"9000336375487"},{"@type":"NRID","@value":"9000325832237"},{"@type":"NRID","@value":"9000412600210"},{"@type":"NRID","@value":"9000413697938"},{"@type":"NRID","@value":"9000329009119"},{"@type":"NRID","@value":"9000410910466"},{"@type":"NRID","@value":"9000255878262"},{"@type":"NRID","@value":"9000403042646"},{"@type":"NRID","@value":"9000239600482"},{"@type":"NRID","@value":"9000410910452"},{"@type":"NRID","@value":"9000255878085"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000012419"}],"foaf:name":[{"@value":"Tetsuya Hosooka"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658311008259","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40101315"},{"@type":"NRID","@value":"1000040101315"},{"@type":"NRID","@value":"9000002737456"},{"@type":"NRID","@value":"9000253202689"},{"@type":"NRID","@value":"9000009292410"},{"@type":"NRID","@value":"9000392669637"},{"@type":"NRID","@value":"9000291597947"},{"@type":"NRID","@value":"9000006690524"},{"@type":"NRID","@value":"9000010448399"},{"@type":"NRID","@value":"9000008107546"},{"@type":"NRID","@value":"9000391641920"},{"@type":"NRID","@value":"9000010951605"},{"@type":"NRID","@value":"9000392666979"},{"@type":"NRID","@value":"9000021491601"},{"@type":"NRID","@value":"9000005276066"},{"@type":"NRID","@value":"9000005274104"},{"@type":"NRID","@value":"9000391630836"},{"@type":"NRID","@value":"9000007152608"},{"@type":"NRID","@value":"9000003763442"},{"@type":"NRID","@value":"9000007274753"},{"@type":"NRID","@value":"9000020743170"},{"@type":"NRID","@value":"9000252815656"},{"@type":"NRID","@value":"9000329009120"},{"@type":"NRID","@value":"9000021405476"},{"@type":"NRID","@value":"9000252810752"},{"@type":"NRID","@value":"9000019945874"},{"@type":"NRID","@value":"9000252819339"},{"@type":"NRID","@value":"9000391619437"},{"@type":"NRID","@value":"9000021305949"},{"@type":"NRID","@value":"9000253523396"},{"@type":"NRID","@value":"9000392669329"}],"foaf:name":[{"@value":"Tadaomi Takenawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01674889"}],"prism:publicationName":[{"@value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2015-12","prism:volume":"1853","prism:number":"12","prism:startingPage":"3192","prism:endingPage":"3201"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S016748891500302X?httpAccept=text/plain"},{"@id":"https://api.elsevier.com/content/article/PII:S016748891500302X?httpAccept=text/xml"}],"createdAt":"2015-09-14","modifiedAt":"2022-06-19","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Phosphatidylinositol-3,4,5-trisphosphate","dc:title":"Phosphatidylinositol-3,4,5-trisphosphate"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Membrane","dc:title":"Cell Membrane"},{"@id":"https://cir.nii.ac.jp/all?q=PI%203-kinase","dc:title":"PI 3-kinase"},{"@id":"https://cir.nii.ac.jp/all?q=Skeletal%20muscle","dc:title":"Skeletal muscle"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphoric%20Monoester%20Hydrolases","dc:title":"Phosphoric Monoester Hydrolases"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=SKIP","dc:title":"SKIP"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Activation","dc:title":"Enzyme Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphatidylinositol%203-Kinases","dc:title":"Phosphatidylinositol 3-Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Glucose-regulated%20protein%2078","dc:title":"Glucose-regulated protein 78"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin","dc:title":"Insulin"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle,%20Skeletal","dc:title":"Muscle, Skeletal"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Endoplasmic%20Reticulum%20Chaperone%20BiP","dc:title":"Endoplasmic Reticulum Chaperone BiP"},{"@id":"https://cir.nii.ac.jp/all?q=Heat-Shock%20Proteins","dc:title":"Heat-Shock Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782142940160","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23227005"},{"@type":"JGN","@value":"JP23227005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23227005/"}],"notation":[{"@language":"ja","@value":"ホスホイノシタイドによる細胞ダイナミズムの制御"},{"@language":"en","@value":"Regulation of cell dynamism by phosphoinositides"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782258103808","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25460365"},{"@type":"JGN","@value":"JP25460365"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460365/"}],"notation":[{"@language":"ja","@value":"骨格筋におけるインスリン抵抗性惹起を引き起こす分子メカニズムの解析"},{"@language":"en","@value":"Analysis of molecular mechanisms underlying induction of insulin resistance in skeletal muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782299993344","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26430143"},{"@type":"JGN","@value":"JP26430143"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430143/"}],"notation":[{"@language":"ja","@value":"質量分析計を用いたがん転移早期検出法の開発"},{"@language":"en","@value":"Development of an early diagnostic system for metastasis using the mass spectrometer"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050294045371033216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360001114001423872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role for Endoplasmic Reticulum Stress in Diabetes 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