{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232000606976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2012.09.131"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X12019092?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X12019092?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23063977"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"All-trans retinoic acid combined with 5-Aza-2′-deoxycitidine induces C/EBPα expression and growth inhibition in MLL-AF9-positive leukemic cells"}],"description":[{"notation":[{"@value":"The present study tested whether all-trans retinoic acid (ATRA) and 5-Aza-2'-deoxycitidine (5-Aza) affect AML cell differentiation and growth in vitro by acting on the CCAAT/enhancer binding protein α (C/EBPα) and c-Myc axis. After exposure to a combination of these agents, cell differentiation and growth arrest were significantly higher in human and murine MLL-AF9-expressing cells than in MLL-AF4/AF5q31-expressing cells, which were partly associated with increased expression of C/EBPα, C/EBPε, and PU.1, and decreased expression of c-Myc. These findings indicate that MLL-AF9-expressing cells are more sensitive to ATRA and 5-Aza, indicating that different MLL fusion proteins possess different epigenetic properties associated with retinoic acid pathway inactivation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232000606983","@type":"Researcher","foaf:name":[{"@value":"Atsushi Fujiki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000606980","@type":"Researcher","foaf:name":[{"@value":"Toshihiko 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Sugita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000606979","@type":"Researcher","foaf:name":[{"@value":"Hajime Hosoi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2012-11","prism:volume":"428","prism:number":"2","prism:startingPage":"216","prism:endingPage":"223"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X12019092?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X12019092?httpAccept=text/plain"}],"createdAt":"2012-10-10","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Oncogene%20Proteins,%20Fusion","dc:title":"Oncogene Proteins, Fusion"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Proteins","dc:title":"Nuclear Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Tretinoin","dc:title":"Tretinoin"},{"@id":"https://cir.nii.ac.jp/all?q=Histone-Lysine%20N-Methyltransferase","dc:title":"Histone-Lysine N-Methyltransferase"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methylation","dc:title":"DNA Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Hematopoietic%20Stem%20Cells","dc:title":"Hematopoietic Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Leukemia,%20Myeloid,%20Acute","dc:title":"Leukemia, Myeloid, Acute"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Resistance,%20Neoplasm","dc:title":"Drug Resistance, Neoplasm"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, 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