{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232000628992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2012.10.073"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X12020451?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X12020451?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23111332"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro"}],"description":[{"notation":[{"@value":"Neuroendocrine regulatory peptide (NERP)-2, recently identified as a bioactive peptide involved in vasopressin secretion and feeding regulation in the central nervous system, is abundantly expressed in endocrine cells in peripheral tissues. To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. NERP-2 increased glucose-stimulated insulin secretion (GSIS) in a dose-dependent manner, with a lowest effective dose of 10(-7) M, from the pancreatic β-cell line MIN6 and isolated mouse pancreatic islets. NERP-2 did not affect insulin secretion under the low-glucose conditions. Neither NERP-1 nor NERP-2-Gly (nonamidated NERP-2) stimulated insulin secretion. NERP-2 significantly augmented GSIS after intravenous administration to anesthetized rats or intraperitoneal injection to conscious mice. We detected NERP-2 in pancreatic islets, where it co-localized extensively with insulin. Calcium-imaging analysis demonstrated that NERP-2 increased the calcium influx in MIN6 cells. These findings reveal that NERP-2 regulates GSIS by elevating intracellular calcium concentrations."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232000629001","@type":"Researcher","foaf:name":[{"@value":"Farhana Naznin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000628996","@type":"Researcher","foaf:name":[{"@value":"Takashi Matsuo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000629003","@type":"Researcher","foaf:name":[{"@value":"Abu Saleh Md. 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Nakazato"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276159370368","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10305097"},{"@type":"NRID","@value":"1000010305097"},{"@type":"NRID","@value":"9000000170437"},{"@type":"NRID","@value":"9000018532165"},{"@type":"NRID","@value":"9000258083487"},{"@type":"NRID","@value":"9000021933233"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0112613"}],"foaf:name":[{"@value":"Hideki Yamaguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751140283264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50124839"},{"@type":"NRID","@value":"1000050124839"},{"@type":"NRID","@value":"9000001072582"},{"@type":"NRID","@value":"9000412603905"},{"@type":"NRID","@value":"9000356631057"},{"@type":"NRID","@value":"9000364741762"},{"@type":"NRID","@value":"9000256378319"},{"@type":"NRID","@value":"9000014672223"},{"@type":"NRID","@value":"9000409991323"},{"@type":"NRID","@value":"9000257777495"},{"@type":"NRID","@value":"9000006522827"},{"@type":"NRID","@value":"9000020804728"},{"@type":"NRID","@value":"9000347093385"},{"@type":"NRID","@value":"9000412603811"},{"@type":"NRID","@value":"9000252769762"},{"@type":"NRID","@value":"9000257768861"},{"@type":"NRID","@value":"9000403737114"},{"@type":"NRID","@value":"9000409991343"},{"@type":"NRID","@value":"9000391978504"},{"@type":"NRID","@value":"9000253205928"},{"@type":"NRID","@value":"9000403736992"},{"@type":"NRID","@value":"9000391981455"},{"@type":"NRID","@value":"9000258733789"},{"@type":"NRID","@value":"9000024583866"},{"@type":"NRID","@value":"9000256867204"},{"@type":"NRID","@value":"9000347090653"},{"@type":"NRID","@value":"9000006136338"},{"@type":"NRID","@value":"9000266428504"},{"@type":"NRID","@value":"9000237858089"},{"@type":"NRID","@value":"9000391981956"},{"@type":"NRID","@value":"9000399221222"},{"@type":"NRID","@value":"9000257769261"},{"@type":"NRID","@value":"9000370257226"},{"@type":"NRID","@value":"9000347090723"},{"@type":"NRID","@value":"9000253183858"},{"@type":"NRID","@value":"9000402945813"},{"@type":"NRID","@value":"9000391982021"},{"@type":"NRID","@value":"9000391625632"},{"@type":"NRID","@value":"9000398990130"},{"@type":"NRID","@value":"9000391959807"},{"@type":"NRID","@value":"9000347093397"},{"@type":"NRID","@value":"9000399373828"},{"@type":"NRID","@value":"9000018658754"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/minamino7010"}],"foaf:name":[{"@value":"Naoto Minamino"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000628999","@type":"Researcher","foaf:name":[{"@value":"Marie Rhee"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326224964992","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80381101"},{"@type":"NRID","@value":"1000080381101"},{"@type":"NRID","@value":"9000018779924"},{"@type":"NRID","@value":"9000257804699"},{"@type":"NRID","@value":"9000003218149"}],"foaf:name":[{"@value":"Koji Toshinai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000628992","@type":"Researcher","foaf:name":[{"@value":"Ji-Wom Kim"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232000629000","@type":"Researcher","foaf:name":[{"@value":"T.M. Zaved Waise"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2012-11","prism:volume":"428","prism:number":"4","prism:startingPage":"512","prism:endingPage":"517"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X12020451?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X12020451?httpAccept=text/plain"}],"createdAt":"2012-10-27","modifiedAt":"2022-01-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Neuropeptides","dc:title":"Neuropeptides"},{"@id":"https://cir.nii.ac.jp/all?q=Nerve%20Tissue%20Proteins","dc:title":"Nerve Tissue Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Glucose","dc:title":"Glucose"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin-Secreting%20Cells","dc:title":"Insulin-Secreting Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin%20Secretion","dc:title":"Insulin Secretion"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin","dc:title":"Insulin"},{"@id":"https://cir.nii.ac.jp/all?q=Nerve%20Growth%20Factors","dc:title":"Nerve Growth Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782112647424","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22390190"},{"@type":"JGN","@value":"JP22390190"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390190/"}],"notation":[{"@language":"ja","@value":"新規視床下部ペプチドの網羅的探索と機能解析"},{"@language":"en","@value":"Comprehensive determination and functional analysis of novel peptides in the hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782124991360","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22591023"},{"@type":"JGN","@value":"JP22591023"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591023/"}],"notation":[{"@language":"ja","@value":"分泌顆粒内ペプチドのスナップショット解析による新規生理活性ペプチド探索"},{"@language":"en","@value":"Snapshot peptidomics for bioactive peptide 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