{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232000708992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2013.01.051"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X13001198?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X13001198?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23352616"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells"}],"description":[{"notation":[{"@value":"Caveolin-1 is highly expressed in prostate cancer cells, and is implicated in disease progression. Here, we identified protein phosphatase 5 (PP5) as a novel cellular binding partner of caveolin-1 using a pull-down approach in combination with mass spectrometry-based proteomic analyses. In situ proximity ligation assays demonstrated co-localization and physical interaction of caveolin-1 and PP5 in the cytoplasm of PC-3 human prostate cancer cells. Using yeast two-hybrid analysis, we found that caveolin-1 interacted with the catalytic domain of PP5. We also found that PP5 activity was elevated about 1.7-fold in the presence of 2 μM caveolin-1, and that the scaffolding domain of caveolin-1 is required for this activation. Our results suggest that caveolin-1 is a novel physiological activator of PP5."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232000708992","@type":"Researcher","foaf:name":[{"@value":"Yuichiro Higashimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276183077504","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20549612"},{"@type":"NRID","@value":"1000020549612"},{"@type":"NRID","@value":"9000006396522"},{"@type":"NRID","@value":"9000256028114"},{"@type":"NRID","@value":"9000366123176"},{"@type":"NRID","@value":"9000258733489"},{"@type":"NRID","@value":"9000250169322"},{"@type":"NRID","@value":"9000413253867"},{"@type":"NRID","@value":"9000241681311"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/2718"}],"foaf:name":[{"@value":"Junichi Taira"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-02","prism:volume":"431","prism:number":"4","prism:startingPage":"724","prism:endingPage":"728"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X13001198?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X13001198?httpAccept=text/plain"}],"createdAt":"2013-01-23","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Caveolin%201","dc:title":"Caveolin 1"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Proteins","dc:title":"Nuclear Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Prostatic%20Neoplasms","dc:title":"Prostatic Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Activation","dc:title":"Enzyme Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Catalytic%20Domain","dc:title":"Catalytic Domain"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Two-Hybrid%20System%20Techniques","dc:title":"Two-Hybrid System Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphoprotein%20Phosphatases","dc:title":"Phosphoprotein Phosphatases"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Sequence","dc:title":"Amino Acid 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