{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232001974272.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2017.10.133"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X17321186?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X17321186?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"29111330"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms"}],"description":[{"notation":[{"@value":"The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular diseases. To investigate the feature of phospholipid composition of IA walls, we conducted IMS in a rat model of experimentally induced IA.IAs were surgically induced in 7-week-old male rats and analyzed by IMS in negative-ion mode.A molecule at m/z 885.5 was more abundant in the thickened wall than in the thinned wall (P = 0.03). Multiple-stage mass spectroscopy revealed the molecule to be phosphatidylinositol containing stearic acid and arachidonic acid (PI 18:0/20:4). Immunohistochemistry indicated that vascular smooth muscle cells (SMCs) in the thickened wall had dedifferentiated phenotypes. To investigate the relationship between accumulation of PI (18:0/20:4) and phenotypic changes in SMCs, we subjected primary mouse aortic SMCs to liquid chromatography-tandem mass spectrometry. Notably, dedifferentiated SMCs had 1.3-fold more PI (18:0/20:4) than partly differentiated SMCs.Our study demonstrated the heterogeneity in phospholipid composition of the aneurysmal walls using experimentally induced IAs. PI (18:0/20:4) accumulated at high levels in the thickened aneurysmal wall where synthetic dedifferentiated SMCs exist, suggesting that this phospholipid may be involved in the phenotypic switching of medial SMCs in the IA wall."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232001974274","@type":"Researcher","foaf:name":[{"@value":"Taichi Ikedo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974276","@type":"Researcher","foaf:name":[{"@value":"Manabu Minami"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974144","@type":"Researcher","foaf:name":[{"@value":"Hiroharu Kataoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974277","@type":"Researcher","foaf:name":[{"@value":"Kosuke Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974278","@type":"Researcher","foaf:name":[{"@value":"Manabu Nagata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974275","@type":"Researcher","foaf:name":[{"@value":"Risako Fujikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974272","@type":"Researcher","foaf:name":[{"@value":"Fumiyoshi Yamazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974273","@type":"Researcher","foaf:name":[{"@value":"Mitsutoshi Setou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974145","@type":"Researcher","foaf:name":[{"@value":"Masayuki Yokode"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001974279","@type":"Researcher","foaf:name":[{"@value":"Susumu Miyamoto"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2018-01","prism:volume":"495","prism:number":"1","prism:startingPage":"332","prism:endingPage":"338"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X17321186?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X17321186?httpAccept=text/plain"}],"createdAt":"2017-10-27","modifiedAt":"2025-09-19","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Spectroscopy","dc:title":"Magnetic Resonance Spectroscopy"},{"@id":"https://cir.nii.ac.jp/all?q=Intracranial%20Aneurysm","dc:title":"Intracranial Aneurysm"},{"@id":"https://cir.nii.ac.jp/all?q=Cerebral%20Arteries","dc:title":"Cerebral Arteries"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Imaging","dc:title":"Magnetic Resonance Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Imaging","dc:title":"Molecular Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Distribution","dc:title":"Tissue Distribution"},{"@id":"https://cir.nii.ac.jp/all?q=Phospholipids","dc:title":"Phospholipids"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256811030144","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H05898"},{"@type":"JGN","@value":"JP15H05898"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-15H05898/"}],"notation":[{"@language":"ja","@value":"脂肪酸クオリティの最先端リピドミクスと生理的意義の解明"},{"@language":"en","@value":"Advanced lipidomics to illuminate the physiological importance of LipoQuality"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256811053568","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H05897"},{"@type":"JGN","@value":"JP15H05897"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-15H05897/"}],"notation":[{"@language":"ja","@value":"「リポクオリティ」領域研究の推進"},{"@language":"en","@value":"Steering group for the LipoQuality program project"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002217036184192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218711226240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144083565568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690790968960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691835656192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286992331637120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165767599232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094357433216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642421819776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571186855552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduction in dietary omega-6 polyunsaturated fatty acids: Eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046019954944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Competence Growth Factors Evoke the Phenotypic Transition of Arterial Smooth Muscle Cells<sup>a</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995262506496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unruptured Intracranial Aneurysms"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995408015360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Smooth muscle cells of human intracranial aneurysms assume phenotypic features similar to those of the atherosclerotic plaque"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468841302528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469126096128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis of Medial Smooth Muscle Cells in the Development of Saccular Cerebral Aneurysms in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471038882176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944435653248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419163012352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endothelial injury and inflammatory response induced by hemodynamic changes preceding intracranial aneurysm formation: experimental study in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893288073216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896331427968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural Fragility and Inflammatory Response of Ruptured Cerebral Aneurysms"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844150718208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844970625920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319963324416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794118996096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phenotypic modulation of smooth muscle cells in human cerebral aneurysmal walls"}]},{"@id":"https://cir.nii.ac.jp/crid/1374228028948405121","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Experimentally induced cerebral aneurysms in rats: Part V. Relation of hemodynamics in the circle of Willis to formation of aneurysms"}]},{"@id":"https://cir.nii.ac.jp/crid/1374228028948405122","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The development and the use of experimental animal models to study the underlying mechanisms of CA formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501116384640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2017.10.133"},{"@type":"KAKEN","@value":"PRODUCT-21613167"},{"@type":"KAKEN","@value":"PRODUCT-21613016"},{"@type":"OPENAIRE","@value":"doi_dedup___::e9e4b5c7c12717ef38c4218d2572ce57"},{"@type":"CROSSREF","@value":"10.1016/j.wneu.2019.05.153_references_DOI_WkHfMiIuu82CMCLG2TpromB5iIG"}]}