{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232001998208.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2017.11.102"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X17322805?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X17322805?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"29155177"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation"}],"description":[{"notation":[{"@value":"Although gemcitabine is an effective chemotherapeutic for pancreatic cancer, severe side effects often accompany its use. Since we have discovered that locally administered C1B domain peptides effectively control tumor growth without any side effects, the efficacy of co-treatment with this peptide and a low dose of gemcitabine on the growth of pancreatic cancer was examined. Two- and three-dimensional cell culture studies clarified that a co-treatment with C1B5 peptide and gemcitabine significantly attenuated growth of PAN02 mouse and PANC-1 human pancreatic cancer cells in 2D and 3D cultures. Although treatment with the low dose of gemcitabine alone (76%) or the C1B5 peptide alone (39%) inhibited tumor growth moderately, a co-treatment with C1B5 peptide and a low dose of gemcitabine markedly inhibited the growth of PAN02 autografts in the mouse peritoneal cavity (94% inhibition) without any noticeable adverse effect. The number of peritoneal cavity-infiltrating neutrophils and granzyme B"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232001998215","@type":"Researcher","foaf:name":[{"@value":"Susumu Ishiguro"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998212","@type":"Researcher","foaf:name":[{"@value":"Atsushi Kawabata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998217","@type":"Researcher","foaf:name":[{"@value":"Alejandro Zulbaran-Rojas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998213","@type":"Researcher","foaf:name":[{"@value":"Kelsey Monson"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998209","@type":"Researcher","foaf:name":[{"@value":"Deepthi Uppalapati"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998208","@type":"Researcher","foaf:name":[{"@value":"Naomi Ohta"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998210","@type":"Researcher","foaf:name":[{"@value":"Makoto Inui"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998211","@type":"Researcher","foaf:name":[{"@value":"Charalampos G. Pappas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998214","@type":"Researcher","foaf:name":[{"@value":"Andreas G. Tzakos"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232001998216","@type":"Researcher","foaf:name":[{"@value":"Masaaki Tamura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier 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