{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232012179072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.biosystems.2013.05.006"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0303264713001317?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0303264713001317?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23711432"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Construction of bacteria–eukaryote synthetic mutualism"}],"description":[{"notation":[{"@value":"Mutualism is ubiquitous in nature but is known to be intrinsically vulnerable with regard to both population dynamics and evolution. Synthetic ecology has indicated that it is feasible for organisms to establish novel mutualism merely through encountering each other by showing that it is feasible to construct synthetic mutualism between organisms. However, bacteria-eukaryote mutualism, which is ecologically important, has not yet been constructed. In this study, we synthetically constructed mutualism between a bacterium and a eukaryote by using two model organisms. We mixed a bacterium, Escherichia coli (a genetically engineered glutamine auxotroph), and an amoeba, Dictyostelium discoideum, in 14 sets of conditions in which each species could not grow in monoculture but potentially could grow in coculture. Under a single condition in which the bacterium and amoeba mutually compensated for the lack of required nutrients (lipoic acid and glutamine, respectively), both species grew continuously through several subcultures, essentially establishing mutualism. Our results shed light on the establishment of bacteria-eukaryote mutualism and indicate that a bacterium and eukaryote pair in nature also has a non-negligible possibility of establishing novel mutualism if the organisms are potentially mutualistic."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232012179078","@type":"Researcher","foaf:name":[{"@value":"Isao Kubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801207488768","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30515565"},{"@type":"NRID","@value":"1000030515565"},{"@type":"NRID","@value":"9000017712352"},{"@type":"NRID","@value":"9000238862583"},{"@type":"NRID","@value":"9000006032251"},{"@type":"NRID","@value":"9000259306428"},{"@type":"NRID","@value":"9000006869662"},{"@type":"NRID","@value":"9000238282373"},{"@type":"NRID","@value":"9000006865557"},{"@type":"NRID","@value":"9000006689806"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0140693"}],"foaf:name":[{"@value":"Kazufumi Hosoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232012179073","@type":"Researcher","foaf:name":[{"@value":"Shingo Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232012179074","@type":"Researcher","foaf:name":[{"@value":"Kayo Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232012179077","@type":"Researcher","foaf:name":[{"@value":"Kumiko Kihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232012179075","@type":"Researcher","foaf:name":[{"@value":"Kotaro Mori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232012179076","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Yomo"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03032647"}],"prism:publicationName":[{"@value":"Biosystems"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-08","prism:volume":"113","prism:number":"2","prism:startingPage":"66","prism:endingPage":"71"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/3.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0303264713001317?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0303264713001317?httpAccept=text/plain"}],"createdAt":"2013-05-24","modifiedAt":"2025-10-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Statistics%20and%20Probability","dc:title":"Statistics and Probability"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry,%20Genetics%20and%20Molecular%20Biology(all)","dc:title":"Biochemistry, Genetics and Molecular Biology(all)"},{"@id":"https://cir.nii.ac.jp/all?q=Applied%20Mathematics","dc:title":"Applied Mathematics"},{"@id":"https://cir.nii.ac.jp/all?q=Population%20Dynamics","dc:title":"Population Dynamics"},{"@id":"https://cir.nii.ac.jp/all?q=Bacteria%E2%80%93eukaryote%20mutualism","dc:title":"Bacteria–eukaryote mutualism"},{"@id":"https://cir.nii.ac.jp/all?q=Mutualism","dc:title":"Mutualism"},{"@id":"https://cir.nii.ac.jp/all?q=Establishment","dc:title":"Establishment"},{"@id":"https://cir.nii.ac.jp/all?q=Modelling%20and%20Simulation","dc:title":"Modelling and Simulation"},{"@id":"https://cir.nii.ac.jp/all?q=Syntrophism","dc:title":"Syntrophism"},{"@id":"https://cir.nii.ac.jp/all?q=Escherichia%20coli","dc:title":"Escherichia coli"},{"@id":"https://cir.nii.ac.jp/all?q=Dictyostelium","dc:title":"Dictyostelium"},{"@id":"https://cir.nii.ac.jp/all?q=Synthetic%20Biology","dc:title":"Synthetic Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Symbiosis","dc:title":"Symbiosis"},{"@id":"https://cir.nii.ac.jp/all?q=Synthetic%20ecology","dc:title":"Synthetic ecology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782183873024","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23770021"},{"@type":"JGN","@value":"JP23770021"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23770021/"}],"notation":[{"@language":"ja","@value":"共生成立に寄与する表現型可塑性の分子機構"},{"@language":"en","@value":"Molecular mechanism of a phenotypic adaptation to establishment of a synthetic bacterial mutualism"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143956524800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Engineering photosynthesis in plants and synthetic microorganisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145640053248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamics in the mixed microbial concourse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618998396032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium."}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619241081856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An observation of the initial stage towards a symbiotic relationship"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620327401472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Contingency and Statistical Laws in Replicate Microbial Closed Ecosystems"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621162636416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Engineering microbial systems to explore ecological and evolutionary dynamics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621361335936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Predator-Prey Interactions of<i>Dictyostelium discoideum</i>and<i>Escherichia coli</i>in Continuous Culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621363704448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Emergent cooperation in microbial metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185563505920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Collective oscillations in developing cells: Insights from simple systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189910019456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Designing symbiosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094600300288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Ecology of Mutualism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569346917760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EcoCyc: a comprehensive database of Escherichia coli biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569651633408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The evolution of mutualisms: exploring the paths between conflict and cooperation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569708083200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unique Colony Housing the Coexisting Escherichia coli and Dictyostelium discoideum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570545636352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Geographic isolation trumps coevolution as a driver of yucca and yucca moth diversification"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044175355648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Auto-/heterotrophic endosymbiosis evolves in a mature stage of ecosystem development in a microcosm composed of an alga, a bacterium and a ciliate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045644434048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutualists with attitude: coevolving fig wasps and figs"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520039553664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global/temporal gene expression analysis of Escherichia coli in the early stages of symbiotic relationship development with the cellular slime mold Dictyostelium discoideum"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520055328128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathways to mutualism breakdown"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520586962816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Growth inhibition as a consequence of antagonism between related amino acids: effect of valine in Escherichia coli K-12"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521176797056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Host-Bacterial Mutualism in the Human Intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994788822784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cooperative Adaptation to Establishment of a Synthetic Bacterial Mutualism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995411989504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A defined minimal medium for axenic strains of\n            <i>Dictyostelium discoideum</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996451811968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Breakdown and delayed cospeciation in the arbuscular mycorrhizal mutualism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468349483648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Engineering ecosystems and synthetic ecologies"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943889081472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cheating and the evolutionary stability of mutualisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944097766272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymmetric Coevolutionary Networks Facilitate Biodiversity Maintenance"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944325033088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of Cellular Dependence on Infective Organisms: Micrurgical Studies in Amoebas"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945334986496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthetic cooperation in engineered yeast populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420414561792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phenotypic plasticity of Escherichia coli at initial stage of symbiosis with Dictyostelium discoideum"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421383200512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipopolysaccharide enhances bactericidal activity in Dictyostelium discoideum cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368509247872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protocols for growth and development of Dictyostelium discoideum"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369082607744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Improvement of a synthetic medium for Dictyostelium discoideum"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369370289152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370319877504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global change in Escherichia coli gene expression in initial stage of symbiosis with Dictyostelium cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370412354048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Using artificial systems to explore the ecology and evolution of symbioses"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845859673472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adaptive characteristics of a ciliateTetrahymena thermophila in endosymbiotic association with a green algaChlorella vulgaris derived in a long-term microcosm culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846014807296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rapid evolution of stability and productivity at the origin of a microbial mutualism"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318330649728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inter-kingdom encounters: recent advances in molecular bacterium–fungus interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320514955392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Probabilistic transition from unstable predator–prey interaction to stable coexistence of Dictyostelium discoideum and Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320578499712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Towards a Synthetic Chloroplast"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794361565184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthetic ecosystems based on airborne inter- and intrakingdom communication"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796158814080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asynchronous Diversification in a Specialized Plant-Pollinator Mutualism"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269527965184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interspecific hybridization in plant‐associated fungi and oomycetes: a review"}]},{"@id":"https://cir.nii.ac.jp/crid/1370569869225957123","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel cooperation experimentally evolved between species"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.biosystems.2013.05.006"},{"@type":"KAKEN","@value":"PRODUCT-14390519"},{"@type":"OPENAIRE","@value":"doi_dedup___::33f580d519ed260ef59bce2a33c00a04"}]}