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PPM1D is a promising target protein in cancer therapy since overexpression, missense mutations, truncating mutations, and gene amplification of PPM1D are reported in many tumors, including breast cancer and neuroblastoma. Herein, we report that a specific inhibitor, SL-176 that can be readily synthesized in 10 steps, significantly inhibits proliferation of a breast cancer cell line overexpressing PPM1D and induces G2/M arrest and apoptosis. SL-176 decreases PPM1D enzyme activity potently and specifically in vitro. These results demonstrate that SL-176 could be a useful lead compound in the development of effective anti-cancer agents."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232015449219","@type":"Researcher","foaf:name":[{"@value":"Sari Ogasawara"}]},{"@id":"https://cir.nii.ac.jp/crid/1070025031478044932","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000334428835"},{"@type":"NRID","@value":"9000262366698"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kiyota"}],"foaf:name":[{"@value":"Yuhei 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Tanino"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232015449221","@type":"Researcher","foaf:name":[{"@value":"Rui Kamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232015449217","@type":"Researcher","foaf:name":[{"@value":"Kazuyasu Sakaguchi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09680896"}],"prism:publicationName":[{"@value":"Bioorganic & Medicinal Chemistry"}],"dc:publisher":[{"@value":"Elsevier 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2C"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphoprotein%20Phosphatases","dc:title":"Phosphoprotein Phosphatases"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=M%20Phase%20Cell%20Cycle%20Checkpoints","dc:title":"M Phase Cell Cycle Checkpoints"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Inhibitors","dc:title":"Enzyme Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Suppressor%20Protein%20p53","dc:title":"Tumor Suppressor Protein p53"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell 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