{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232016959488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bmcl.2014.11.072"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0960894X14012797?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0960894X14012797?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"25510375"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state 2H NMR probe for investigating membrane properties"}],"description":[{"notation":[{"@value":"Lipid organization has been at the center of research on lipid rafts. Dioleoylphosphatidylcholine (DOPC) is a typical unsaturated lipid. Very few studies have reported its thermodynamics in raft-like membranes. Herein, we have developed a highly efficient synthetic method for [C6-(2)H2] oleic acid, and newly synthesized [C6-(2)H2] DOPC. In raft-like oriented bilayers, [C6-(2)H2] DOPC shows clear phase separation and characteristic phase behavior at various temperature. It has been successfully utilized for the comparison of membrane properties between sphingomyelin (SM) and dihydrosphingomyelin (DHSM) membranes."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232016959490","@type":"Researcher","foaf:name":[{"@value":"Jin Cui"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232016959489","@type":"Researcher","foaf:name":[{"@value":"Sébastien Lethu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232016959493","@type":"Researcher","foaf:name":[{"@value":"Tomokazu Yasuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751141933568","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60456184"},{"@type":"NRID","@value":"1000060456184"},{"@type":"NRID","@value":"9000019967029"},{"@type":"NRID","@value":"9000312843756"},{"@type":"NRID","@value":"9000311788211"},{"@type":"NRID","@value":"9000411831985"},{"@type":"NRID","@value":"9000004193460"},{"@type":"NRID","@value":"9000411815182"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/matsuokashigeru"}],"foaf:name":[{"@value":"Shigeru Matsuoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232016959492","@type":"Researcher","foaf:name":[{"@value":"Nobuaki Matsumori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232016959494","@type":"Researcher","foaf:name":[{"@value":"Fuminori Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232016959491","@type":"Researcher","foaf:name":[{"@value":"Michio Murata"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0960894X"}],"prism:publicationName":[{"@value":"Bioorganic & Medicinal Chemistry Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2015-01","prism:volume":"25","prism:number":"2","prism:startingPage":"203","prism:endingPage":"206"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0960894X14012797?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0960894X14012797?httpAccept=text/plain"}],"createdAt":"2014-12-04","modifiedAt":"2025-10-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Spectroscopy","dc:title":"Magnetic Resonance Spectroscopy"},{"@id":"https://cir.nii.ac.jp/all?q=Organic%20Chemistry","dc:title":"Organic Chemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Clinical%20Biochemistry","dc:title":"Clinical Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Pharmaceutical%20Science","dc:title":"Pharmaceutical Science"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Microdomains","dc:title":"Membrane Microdomains"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Discovery","dc:title":"Drug Discovery"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphatidylcholines","dc:title":"Phosphatidylcholines"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Medicine","dc:title":"Molecular Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Oleic%20Acid","dc:title":"Oleic Acid"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782309068672","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26560436"},{"@type":"JGN","@value":"JP26560436"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26560436/"}],"notation":[{"@language":"ja","@value":"細胞膜表面の環境により誘起される分子の三次元構造と認識"},{"@language":"en","@value":"Molecular recognition in the interfacial environment induced by lipid membranes"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257200864384","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24681045"},{"@type":"JGN","@value":"JP24681045"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24681045/"}],"notation":[{"@language":"ja","@value":"脂肪酸結合タンパク質のあいまいな分子認識の構造基盤"},{"@language":"en","@value":"Structural basis for fuzzy molecular recognition by fatty acid-binding protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257254942080","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26102527"},{"@type":"JGN","@value":"JP26102527"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26102527/"}],"notation":[{"@language":"ja","@value":"脂質ラフトにおける脂質分子の動的秩序解析"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050870761359523712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lipid Compositions of Liquid-Ordered and Liquid-Disordered Phases in Ternary Membranes of Sphingomyelin, Cholesterol, and Dioleoylphosphatidylcholine Determined by 2H NMR : Stearoyl-Sphingomyelin Compared with Its Palmitoyl Counterpart"},{"@value":"Lipid Compositions of Liquid-Ordered and Liquid-Disordered Phases in Ternary Membranes of Sphingomyelin, Cholesterol, and Dioleoylphosphatidylcholine Determined by <sup>2</sup>H NMR: 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