{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232017008896.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bmcl.2015.05.050"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0960894X15005247?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0960894X15005247?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"26071638"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Calculation of the HOMO localization of Tetrahymena and Oxytricha telomeric quadruplex DNA"}],"description":[{"notation":[{"@value":"Several guanine-rich sequences exist in many important regions, such as telomeres, and these sequences can form quadruplex DNA structures. It was previously reported that 3'-guanines are mainly oxidized in the Tetrahymena and Oxytricha telomeric quadruplex DNA, d(TGGGGT)4, and 5'-guanines are mainly oxidized in the human telomeric quadruplex DNA, d(TAGGGT)4T. We speculated that the differences in site reactivity between d(TGGGGT)4 and d(TAGGGT)4T are induced by the localization of the HOMO. The HOMOs of the possible quadruplex structures were thus determined and the results showed that the HOMOs of d(TGGGGT)4 +3K(+) and d(TAGGGT)4T +2K(+) localized at the 5'-guanine, and that the HOMO shifted from the 5'-guanine to the 3'-guanine by the addition of a 5'-capping cation. Furthermore, we determined the influence of the cation and demonstrated that localization of the HOMO at the G-quartet plane located immediately adjacent to the cation is disfavored. The calculated HOMO localization of d(TGGGGT)4 +4K(+) and d(TAGGGT)4T +2K(+) matched the experimental results and suggest that d(TGGGGT)4 contains a 5'-capping cation in solution."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232017008898","@type":"Researcher","foaf:name":[{"@value":"Masayuki Morikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326234863232","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70360534"},{"@type":"NRID","@value":"1000070360534"},{"@type":"NRID","@value":"9000006640082"},{"@type":"NRID","@value":"9000364822371"},{"@type":"NRID","@value":"9000257967128"},{"@type":"NRID","@value":"9000318156986"},{"@type":"NRID","@value":"9000398143772"},{"@type":"NRID","@value":"9000272989340"},{"@type":"NRID","@value":"9000397801721"},{"@type":"NRID","@value":"9000006373636"},{"@type":"NRID","@value":"9000364822409"},{"@type":"NRID","@value":"9000356511503"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054010"}],"foaf:name":[{"@value":"Katsuhito Kino"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017008897","@type":"Researcher","foaf:name":[{"@value":"Takanori Oyoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017009026","@type":"Researcher","foaf:name":[{"@value":"Masayo Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017008896","@type":"Researcher","foaf:name":[{"@value":"Takanobu Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017009025","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Miyazawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0960894X"}],"prism:publicationName":[{"@value":"Bioorganic & Medicinal Chemistry Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2015-08","prism:volume":"25","prism:number":"16","prism:startingPage":"3359","prism:endingPage":"3362"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0960894X15005247?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0960894X15005247?httpAccept=text/plain"}],"createdAt":"2015-05-29","modifiedAt":"2025-10-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Molecular","dc:title":"Models, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Oxytricha","dc:title":"Oxytricha"},{"@id":"https://cir.nii.ac.jp/all?q=Organic%20Chemistry","dc:title":"Organic Chemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Clinical%20Biochemistry","dc:title":"Clinical Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Pharmaceutical%20Science","dc:title":"Pharmaceutical Science"},{"@id":"https://cir.nii.ac.jp/all?q=DNA","dc:title":"DNA"},{"@id":"https://cir.nii.ac.jp/all?q=Telomere","dc:title":"Telomere"},{"@id":"https://cir.nii.ac.jp/all?q=G-quadruplexes","dc:title":"G-quadruplexes"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=G-Quadruplexes","dc:title":"G-Quadruplexes"},{"@id":"https://cir.nii.ac.jp/all?q=Cations","dc:title":"Cations"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Discovery","dc:title":"Drug Discovery"},{"@id":"https://cir.nii.ac.jp/all?q=Tetrahymena","dc:title":"Tetrahymena"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20damage","dc:title":"DNA damage"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Medicine","dc:title":"Molecular Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Nucleic%20Acid%20Conformation","dc:title":"Nucleic Acid Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Photooxidation","dc:title":"Photooxidation"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidation-Reduction","dc:title":"Oxidation-Reduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257415176832","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"13J10124"},{"@type":"JGN","@value":"JP13J10124"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13J10124/"}],"notation":[{"@language":"ja","@value":"グアニン酸化損傷から生じる点突然変異の回避機構の解明"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011142935552896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer 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