{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232017348736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bmcl.2019.01.010"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0960894X19300101?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0960894X19300101?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"30738662"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Chemical screening of novel strigolactone agonists that specifically interact with DWARF14 protein"}],"description":[{"notation":[{"@value":"Strigolactones (SLs) are a class of plant hormones that regulate shoot branching as well as being known as root-derived signals for parasitic and symbiotic interactions. The physical interaction between SLs and the DWARF14 (D14) receptor family can be examined by differential scanning fluorimetry (DSF) that monitors the changes in protein melting temperature (Tm). The Tm of D14 is lowered by bioactive SLs in DSF analysis. In this report, we screened the compounds that lower the Tm of Arabidopsis D14 (AtD14) as potential candidates for SL agonists using DSF analysis. Subsequent physiological analyzes revealed that 113D10 acts as a novel SL agonist in a D14-dependent manner. Intriguingly, 113D10 has a chemical structure different from natural SLs in that it does not possess an enol ether bond that connects to a methylbutenolide moiety. Moreover, 113D10 does not stimulate seed germination of root parasitic plants. Accordingly, 113D10 can be a useful tool for SL studies and agricultural applications."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232017348736","@type":"Researcher","foaf:name":[{"@value":"Rei Yasui"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276185381632","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40620282"},{"@type":"NRID","@value":"1000040620282"},{"@type":"NRID","@value":"9000240536073"},{"@type":"NRID","@value":"9000018470017"},{"@type":"NRID","@value":"9000399535901"},{"@type":"NRID","@value":"9000396160661"},{"@type":"NRID","@value":"9000021234990"},{"@type":"NRID","@value":"9000398279674"},{"@type":"NRID","@value":"9000398406035"},{"@type":"NRID","@value":"9000414516612"},{"@type":"NRID","@value":"9000414761406"},{"@type":"NRID","@value":"9000411077322"},{"@type":"NRID","@value":"9000350653491"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/seto_448"}],"foaf:name":[{"@value":"Yoshiya Seto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017348742","@type":"Researcher","foaf:name":[{"@value":"Shinsaku Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017348739","@type":"Researcher","foaf:name":[{"@value":"Kojiro Kawada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017348737","@type":"Researcher","foaf:name":[{"@value":"Kaori Itto-Nakama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232017348738","@type":"Researcher","foaf:name":[{"@value":"Kiyoshi Mashiguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801193764864","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10332298"},{"@type":"NRID","@value":"1000010332298"},{"@type":"ORCID","@value":"0000-0002-0786-1757"},{"@type":"NRID","@value":"9000000271862"},{"@type":"NRID","@value":"9000413488190"},{"@type":"NRID","@value":"9000242902760"},{"@type":"NRID","@value":"9000391922624"},{"@type":"NRID","@value":"9000240536075"},{"@type":"NRID","@value":"9000020655805"},{"@type":"NRID","@value":"9000391956408"},{"@type":"NRID","@value":"9000391935656"},{"@type":"NRID","@value":"9000391919847"},{"@type":"NRID","@value":"9000107388199"},{"@type":"NRID","@value":"9000018525299"},{"@type":"NRID","@value":"9000391937848"},{"@type":"NRID","@value":"9000391934231"},{"@type":"NRID","@value":"9000391945948"},{"@type":"NRID","@value":"9000391922676"},{"@type":"NRID","@value":"9000000199928"},{"@type":"NRID","@value":"9000391942635"},{"@type":"NRID","@value":"9000391932623"},{"@type":"NRID","@value":"9000391920864"},{"@type":"NRID","@value":"9000391937919"},{"@type":"NRID","@value":"9000018278428"},{"@type":"NRID","@value":"9000391923608"},{"@type":"NRID","@value":"9000413528666"},{"@type":"NRID","@value":"9000391919758"},{"@type":"NRID","@value":"9000001316748"},{"@type":"NRID","@value":"9000391937933"},{"@type":"NRID","@value":"9000398406036"},{"@type":"NRID","@value":"9000391942054"},{"@type":"NRID","@value":"9000391922398"},{"@type":"NRID","@value":"9000391922641"},{"@type":"NRID","@value":"9000252878075"},{"@type":"NRID","@value":"9000001624105"},{"@type":"NRID","@value":"9000391932637"},{"@type":"NRID","@value":"9000391932631"},{"@type":"NRID","@value":"9000391919711"},{"@type":"NRID","@value":"9000414516613"},{"@type":"NRID","@value":"9000414761407"},{"@type":"NRID","@value":"9000000224291"},{"@type":"NRID","@value":"9000391934094"},{"@type":"NRID","@value":"9000391918014"},{"@type":"NRID","@value":"9000283588786"},{"@type":"NRID","@value":"9000413504049"},{"@type":"NRID","@value":"9000408573003"},{"@type":"NRID","@value":"9000391934101"},{"@type":"NRID","@value":"9000253471264"},{"@type":"NRID","@value":"9000391952397"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000002144"}],"foaf:name":[{"@value":"Shinjiro Yamaguchi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0960894X"}],"prism:publicationName":[{"@value":"Bioorganic & Medicinal Chemistry Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-04","prism:volume":"29","prism:number":"7","prism:startingPage":"938","prism:endingPage":"942"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0960894X19300101?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0960894X19300101?httpAccept=text/plain"}],"createdAt":"2019-01-10","modifiedAt":"2025-10-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Structure","dc:title":"Molecular Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Arabidopsis%20Proteins","dc:title":"Arabidopsis Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Arabidopsis","dc:title":"Arabidopsis"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Cell%20Surface","dc:title":"Receptors, Cell Surface"},{"@id":"https://cir.nii.ac.jp/all?q=Lactones","dc:title":"Lactones"},{"@id":"https://cir.nii.ac.jp/all?q=Structure-Activity%20Relationship","dc:title":"Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Plant","dc:title":"Gene Expression Regulation, Plant"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781960493952","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17J00463"},{"@type":"JGN","@value":"JP17J00463"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17J00463/"}],"notation":[{"@language":"ja","@value":"新規アゴニストによるストリゴラクトン受容機構の解明と枝分かれの選択的制御法の開発"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256936498816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H06474"},{"@type":"JGN","@value":"JP17H06474"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06474/"}],"notation":[{"@language":"ja","@value":"幹細胞新生のタイミングを制御する分子機構の解明"},{"@language":"en","@value":"Molecular mechanisms for the timing of the production of stem cells in plants"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002217651999744","@type":"Article","resourceType":"学術雑誌論文(journal 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Tillers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795187878528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Karrikins enhance light responses during germination and seedling development in\n            <i>Arabidopsis thaliana</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269514601216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Target-based selectivity of strigolactone agonists and antagonists in plants and their potential use in agriculture"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270853264128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diverse Roles of Strigolactones in Plant Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271034515328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Strigolactone inhibition of shoot 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