Does a shift to limited glucose activate checkpoint control in fission yeast?
書誌事項
- 公開日
- 2014-05-08
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by-nc-nd/4.0/
- DOI
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- 10.1016/j.febslet.2014.04.047
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Here we review cell cycle control in the fission yeast, <jats:italic>Schizosaccharomyces pombe,</jats:italic> in response to an abrupt reduction of glucose concentration in culture media. <jats:italic>S. pombe</jats:italic> arrests cell cycle progression when transferred from media containing 2.0% glucose to media containing 0.1%. After a delay, <jats:italic>S. pombe</jats:italic> resumes cell division at a surprisingly fast rate, comparable to that observed in 2% glucose. We found that a number of genes, including zinc‐finger transcription factor Scr1, CaMKK‐like protein kinase Ssp1, and glucose transporter Ght5, enable rapid cell division in low glucose. In this article, we examine whether cell cycle checkpoint‐like control operates during the delay and after resumption of cell division in limited‐glucose. Using microarray analysis and genetic screening, we identified several candidate genes that may be involved in controlling this low‐glucose adaptation.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 588 (15), 2373-2378, 2014-05-08
Wiley
