{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232159702144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.freeradbiomed.2011.01.024"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0891584911000451?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0891584911000451?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"21277973"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"(−)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68"}],"description":[{"notation":[{"@value":"(-)-Epigallocatechin-3-gallate (EGCG), the most abundant and biologically active polyphenol in green tea, induces apoptosis and suppresses proliferation of cancer cells by modulating multiple signal transduction pathways. However, the fundamental mechanisms responsible for these cancer-preventive effects have not been clearly elucidated. Recently, we found that EGCG can covalently bind to cysteine residues in proteins through autoxidation and subsequently modulate protein function. In this study, we demonstrate the direct binding of EGCG to cellular proteins in AZ521 human gastric cancer cells by redox-cycle staining. We comprehensively explored the binding targets of EGCG from EGCG-treated AZ521 cells by proteomics techniques combined with the boronate-affinity pull-down method. The DEAD-box RNA helicase p68, which is overexpressed in a variety of tumor cells and plays an important role in cancer development and progression, was identified as a novel EGCG-binding target. Exposure of AZ521 cells to EGCG lowered the p68 level dose dependently. The present findings show that EGCG inhibits AZ521 cell proliferation by preventing β-catenin oncogenic signaling through proteasomal degradation of p68 and provide a new perspective on the molecular mechanism of EGCG action."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801197900928","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50150199"},{"@type":"NRID","@value":"1000050150199"},{"@type":"NRID","@value":"9000018525582"},{"@type":"NRID","@value":"9000004152791"},{"@type":"NRID","@value":"9000326271024"},{"@type":"NRID","@value":"9000257923917"},{"@type":"NRID","@value":"9000018563540"},{"@type":"NRID","@value":"9000001994550"},{"@type":"NRID","@value":"9000018473283"},{"@type":"NRID","@value":"9000257820911"},{"@type":"NRID","@value":"9000004242694"},{"@type":"NRID","@value":"9000018471221"},{"@type":"NRID","@value":"9000001776609"},{"@type":"NRID","@value":"9000259835669"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tsutomu8202-RM"}],"foaf:name":[{"@value":"Tsutomu Nakayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232159702148","@type":"Researcher","foaf:name":[{"@value":"Tomoko 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Kumazawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08915849"}],"prism:publicationName":[{"@value":"Free Radical Biology and Medicine"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2011-05","prism:volume":"50","prism:number":"10","prism:startingPage":"1324","prism:endingPage":"1335"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0891584911000451?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0891584911000451?httpAccept=text/plain"}],"createdAt":"2011-01-27","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Conformation","dc:title":"Molecular Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Antineoplastic%20Agents","dc:title":"Antineoplastic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Stereoisomerism","dc:title":"Stereoisomerism"},{"@id":"https://cir.nii.ac.jp/all?q=Catechin","dc:title":"Catechin"},{"@id":"https://cir.nii.ac.jp/all?q=DEAD-box%20RNA%20Helicases","dc:title":"DEAD-box RNA Helicases"},{"@id":"https://cir.nii.ac.jp/all?q=Structure-Activity%20Relationship","dc:title":"Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Stomach%20Neoplasms","dc:title":"Stomach Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Cells,%20Cultured","dc:title":"Tumor Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Screening%20Assays,%20Antitumor","dc:title":"Drug Screening Assays, Antitumor"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782082883456","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21580148"},{"@type":"JGN","@value":"JP21580148"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580148/"}],"notation":[{"@language":"ja","@value":"茶カテキン類と生体成分の分子間相互作用に関する化学生物学的解明"},{"@language":"en","@value":"Chemical biology of molecular interaction between tea catechins with biological substances"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782135705088","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22780124"},{"@type":"JGN","@value":"JP22780124"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22780124/"}],"notation":[{"@language":"ja","@value":"ビタミン候補物質ピロロキノリンキノン(PQQ)と結合する蛋白質の同定と機能解析"},{"@language":"en","@value":"Identification and characterization of protein bindingto pyrroloquinoline quinone (PQQ), a vitamin-like substance"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257099294720","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22580129"},{"@type":"JGN","@value":"JP22580129"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22580129/"}],"notation":[{"@language":"ja","@value":"フラボノイド代謝物DOPACをプローブとした生体分子修飾の解析"},{"@language":"en","@value":"Development of a new probe of a flavonoid metabolite, DOPAC, for understanding the biomolecule modification"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257112415616","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22780122"},{"@type":"JGN","@value":"JP22780122"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22780122/"}],"notation":[{"@language":"ja","@value":"フラボノイド類と蛋白質との相互作用解析による生理作用発現機構の解明"},{"@language":"en","@value":"Analysis of interaction between flavonoids and proteins for elucidating their physiological expression mechanisms."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004237630036224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144516182784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphorylation of p68 RNA Helicase Plays a Role in Platelet-derived Growth Factor-induced Cell Proliferation by Up-regulating Cyclin D1 and c-Myc Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144710284416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Amine oxidase‐like activity of polyphenols"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146012646784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Catechol Type 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