{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232170146048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.gep.2010.09.002"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1567133X1000089X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1567133X1000089X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"20837165"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Gene expression analysis of Six3, Pax6, and Otx in the early development of the stalked crinoid Metacrinus rotundus"}],"description":[{"notation":[{"@value":"The stalked crinoid, Metacrinus rotundus, is one of the most basal extant echinoderms. Here, we show the expression patterns of Six3, Pax6, and Otx in the early development of M. rotundus. All three genes are highly expressed in stages from the gastrula to the auricularia larval stage. Ectodermal expression of MrOtx appears to be correlated with development of the ciliary band. These three genes are expressed sequentially along the embryonic body axis in the anterior and middle walls of the archenteron in the order of MrPax6, MrSix3, and MrOtx. The anterior, middle, and posterior parts of the archenteron in the late gastrula differentiate into the axo-hydrocoel, the enteric sac, and somatocoels at later stages, respectively. The three genes are expressed sequentially from the tip of the axo-hydrocoel to the bottom of enteric sac in the order of MrSix3, MrPax6, and MrOtx at the later stages. This suggests that these genes are involved in patterning of the larval endo-mesoderm in stalked crinoids. The present results suggest that radical alterations have occurred in the expression and function of homeobox genes in basal echinoderms."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232170146050","@type":"Researcher","foaf:name":[{"@value":"Akihito Omori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232170146051","@type":"Researcher","foaf:name":[{"@value":"Koji Akasaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232170146048","@type":"Researcher","foaf:name":[{"@value":"Daisuke Kurokawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232170146049","@type":"Researcher","foaf:name":[{"@value":"Shonan Amemiya"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1567133X"}],"prism:publicationName":[{"@value":"Gene Expression Patterns"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2011-01","prism:volume":"11","prism:number":"1-2","prism:startingPage":"48","prism:endingPage":"56"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1567133X1000089X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1567133X1000089X?httpAccept=text/plain"}],"createdAt":"2010-09-16","modifiedAt":"2021-11-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Homeodomain%20Proteins","dc:title":"Homeodomain Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Profiling","dc:title":"Gene Expression Profiling"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Developmental","dc:title":"Gene Expression Regulation, Developmental"},{"@id":"https://cir.nii.ac.jp/all?q=Cloning,%20Molecular","dc:title":"Cloning, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Echinodermata","dc:title":"Echinodermata"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257140688640","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23570248"},{"@type":"JGN","@value":"JP23570248"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23570248/"}],"notation":[{"@language":"ja","@value":"棘皮動物の前後軸・背腹軸形成の研究"},{"@language":"en","@value":"Study on anteroposterior and dorsoventral axes in echinoderm"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231239738752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Patterning of anteroposterior body axis displayed in the expression of Hox genes in sea cucumber Apostichopus japonicus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235479233920","@type":"Article","resourceType":"学術雑誌論文(journal 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