{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232174552064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.hal.2011.02.006"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1568988311000199?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1568988311000199?httpAccept=text/plain"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Unique amnesic shellfish toxin composition found in the South East Asian diatom Nitzschia navis-varingica"}],"description":[{"notation":[{"@value":"Abstract   Nitzschia navis-varingica is a diatom that is known to produce significant levels of amnesic shellfish poisoning (ASP) toxins. A total of 33 N. navis-varingica strains were isolated from four brackish water localities in the Philippines and Indonesia, and cultured to characterize the toxins produced. The isolates were analyzed for domoic acid (DA) and isodomoic acids A (IA) and B (IB) by HPLC with fluorescence detection. Two toxin composition types were detected that have not been previously described: strains producing only IB and strains producing DA–IA–IB. These two types were isolated from two different localities. Eighteen strains were isolated from the Philippines (northern Luzon Island). Among them, 10 isolates from Alaminos produced only IB with an average toxin content of 3.05 pg cell−1, seven isolates from Bulacan produced DA and IB with average toxin contents of 0.68 pg cell−1 and 1.18 pg cell−1, respectively. One isolate from Cavite produced DA, IA, and IB with a toxin content of 0.58, 0.20, and 0.92 pg cell−1, respectively. Fifteen isolates from Indonesia (Bone, South Sulawesi) produced only DA (four isolates) or DA with trace amounts of IB (eleven isolates), with an average toxin content of 2.38 pg cell−1 and 0.06 pg cell−1, respectively. Sub-strains were established from strains producing either of the three toxin types: IB, DA–IA–IB, and DA-trace IB. Results showed that the toxin composition type was the same for parent and sub-strains, indicating that the toxin composition is a stable character for a strain."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232174551936","@type":"Researcher","foaf:name":[{"@value":"Marc Lawrence J. 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BV"}],"prism:publicationDate":"2011-07","prism:volume":"10","prism:number":"5","prism:startingPage":"456","prism:endingPage":"462"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1568988311000199?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1568988311000199?httpAccept=text/plain"}],"createdAt":"2011-03-07","modifiedAt":"2025-10-27","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782164456448","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23580285"},{"@type":"JGN","@value":"JP23580285"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580285/"}],"notation":[{"@language":"ja","@value":"海産生物における記憶喪失性貝毒の生産・動態に関する研究"},{"@language":"en","@value":"A study on ASP toxin production and dynamics in toxin producing organisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257009030912","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20310006"},{"@type":"JGN","@value":"JP20310006"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20310006/"}],"notation":[{"@language":"ja","@value":"海洋表層におけるケイ素と炭素の生物地球化学的循環のカップリング"},{"@language":"en","@value":"Coupling of silicon and carbon biogeochemical cycles in the surface ocean"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143753744256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710655487744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MORPHOLOGY AND MOLECULAR CHARACTERIZATION OF <i>PSEUDO‐NITZSCHIA</i> (BACILLARIOPHYCEAE) FROM MALAYSIAN BORNEO, INCLUDING THE NEW SPECIES <i>PSEUDO‐NITZSCHIA CIRCUMPORA</i> SP. NOV"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754824197120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"First record of the diatom Nitzschia navis-varingica (Bacillariophyceae) producing amnesic shellfish poisoning-toxins from Papua New Guinea"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182128025216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diatom Nitzschia navis-varingica (Bacillariophyceae) and its domoic acid production from the mangrove environments of Malaysia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095549950336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative toxicity to mice of domoic acid and isodomoic acids A, B and C"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657104686080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Toxin production and temperature-induced morphological variation of the diatom Pseudo-nitzschia seriata from the Arctic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658413565440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Six domoic acid related compounds from the red alga, Chondria armata, and domoic acid biosynthesis by the diatom, Pseudo-nitzschia multiseries"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043709275776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pennate Diatom <i>Nitzschia pungens</i> as the Primary Source of Domoic Acid, a Toxin in Shellfish from Eastern Prince Edward Island, Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519276283520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isodomoic Acid C, an Unusual Amnesic Shellfish Poisoning Toxin from <i>Pseudo-nitzschia australis</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469495470976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MORPHOLOGY OF THE MARINE DIATOM <i>NITZSCHIA NAVIS‐VARINGICA</i>, SP. 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(BACILLARIOPHYCEAE), ANOTHER PRODUCER OF THE NEUROTOXIN DOMOIC ACID"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945506349568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Toxic Pseudo-nitzschia multistriata (Bacillariophyceae) from the Gulf of Naples: morphology, toxin analysis and phylogenetic relationships with other Pseudo-nitzschia species"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945640759040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CONFIRMATION OF DOMOIC ACID PRODUCTION BY <i>PSEUDONITZSCHIA AUSTRALIS</i> (BACILLARIOPHYCEAE) CULTURES<sup>1</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946438598784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of isodomoic acids A and B as major toxin components of a pennate diatom Nitzschia navis-varingica"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419041163392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DOMOIC‐ACID‐PRODUCING DIATOMS: ANOTHER GENUS ADDED!"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419524124544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Trace Determination of Domoic Acid in Sea Water and Phytoplankton by High-Performance Liquid Chromatography of the Fluorenylmethoxycarbonyl (FMOC) Derivative"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419912225536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Domoic acid, the toxic amino acid responsible for amnesic shellfish poisoning, now in Pseudonitzschia seriata (Bacillariophyceae) in Europe"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420312409856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of potentially toxic\n                    <i>Pseudo‐nitzschia</i>\n                    (Bacillariophyceae) in New Zealand coastal waters, using lectins"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368714092672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nitzschia pseudodelicatissima - a source of domoic acid in the Bay of Fundy, eastern Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371206692992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ISOLATION OF ASP TOXIN-PRODUCING NITZSCHIA FROM THAILAND"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845519460480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Occurrence of domoic acid in tropical bivalves"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319469909888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DOMOIC ACID PRODUCTION IN <i>NITZSCHIA</i> SP. 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