{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232182001920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.humpath.2016.10.028"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S004681771730045X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S004681771730045X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"28232159"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucosa-associated lymphoid tissue lymphoma presenting with multiple mass lesions"}],"description":[{"notation":[{"@value":"Crystal-storing histiocytosis (CSH) is an uncommon finding in lymphoplasmacytic disorders that presents histiocytes with abnormal intralysosomal accumulations of immunoglobulin light chains as crystals of unknown etiology. A 38-year-old woman with antiphospholipid syndrome had a surgical lung biopsy because of multiple lung mass lesions. In a right middle lobe lesion, lymphoplasmacytic cells had a monocytoid appearance, destructive lymphoepithelial lesions, and positive immunoglobulin heavy chain (IGH) gene rearrangements. A right upper lobe lesion manifested proliferating rounded histiocytes with abundant, deeply eosinophilic cytoplasm and negative IGH gene rearrangements. Electron microscopy and mass spectrometry revealed a case of pulmonary CSH: abnormal proliferation of the immunoglobulin κ chain of a variable region that may be crystallized within plasma cells and histiocytes. We report a rare case of localized pulmonary CSH complicating pulmonary mucosa-associated lymphoid tissue lymphoma with multiple mass lesions. We demonstrate advances in the understanding of the pathogenesis of CSH by various analyses of these lesions."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030285133525482496","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90595167"},{"@type":"NRID","@value":"1000090595167"},{"@type":"NRID","@value":"9000383075990"}],"foaf:name":[{"@value":"Nariaki Kokuho"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232182001920","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Terasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276172773504","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30350036"},{"@type":"NRID","@value":"1000030350036"},{"@type":"NRID","@value":"9000256002946"},{"@type":"NRID","@value":"9000004445247"},{"@type":"NRID","@value":"9000255696524"},{"@type":"NRID","@value":"9000001218345"},{"@type":"NRID","@value":"9000240057693"},{"@type":"NRID","@value":"9000255696052"},{"@type":"NRID","@value":"9000256005906"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/skunugi-nms"}],"foaf:name":[{"@value":"Shinobu Kunugi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232182001925","@type":"Researcher","foaf:name":[{"@value":"Naomi Onda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232182001929","@type":"Researcher","foaf:name":[{"@value":"Hirokazu 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Shimizu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00468177"}],"prism:publicationName":[{"@value":"Human Pathology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2017-07","prism:volume":"65","prism:startingPage":"180","prism:endingPage":"186"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S004681771730045X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S004681771730045X?httpAccept=text/plain"}],"createdAt":"2017-02-22","modifiedAt":"2022-06-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Rearrangement","dc:title":"Gene Rearrangement"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Neoplasms","dc:title":"Lung Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Immunoglobulin%20Heavy%20Chain","dc:title":"Genes, Immunoglobulin Heavy 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