{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232190048640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ijcard.2012.06.094"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0167527312008856?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0167527312008856?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22795243"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Indoxyl sulfate, a uremic toxin, and carotid intima-media thickness in patients with coronary artery disease"}],"description":[{"notation":[{"@value":"coronary artery disease☆ Bummei Sato , Daiji Yoshikawa ⁎, Hideki Ishii , Ryosuke Kikuchi , Takeshi Arima , Kyosuke Takeshita , Yosuke Inoue , Susumu Suzuki , Miho Tanaka , Soichiro Kumagai , Masaya Matsumoto , Mutsuharu Hayashi , Hirohiko Ando , Tetsuya Amano , Tatsuaki Matsubara , Toshimitsu Niwa , Toyoaki Murohara a a Department of Cardiology, Nagoya University Graduate School of Medicine, Japan b Department of Clinical Laboratory, Nagoya University Hospital, Japan c Department of Cardiology, Aichi Medical University, Japan d Department of Internal Medicine, School of Dentistry, Aichi-Gakuin University, Japan e Department of Advanced Medicine for Uremia, Nagoya University Graduate School of Medicine, Japan"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232190048648","@type":"Researcher","foaf:name":[{"@value":"Bummei Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048645","@type":"Researcher","foaf:name":[{"@value":"Daiji Yoshikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048513","@type":"Researcher","foaf:name":[{"@value":"Hideki Ishii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048515","@type":"Researcher","foaf:name":[{"@value":"Ryosuke Kikuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048640","@type":"Researcher","foaf:name":[{"@value":"Takeshi Arima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048647","@type":"Researcher","foaf:name":[{"@value":"Kyosuke Takeshita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048514","@type":"Researcher","foaf:name":[{"@value":"Yosuke Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048512","@type":"Researcher","foaf:name":[{"@value":"Susumu Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048646","@type":"Researcher","foaf:name":[{"@value":"Hirohiko Ando"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048649","@type":"Researcher","foaf:name":[{"@value":"Miho Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048518","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Amano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048641","@type":"Researcher","foaf:name":[{"@value":"Tatsuaki Matsubara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048643","@type":"Researcher","foaf:name":[{"@value":"Toshimitsu Niwa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048516","@type":"Researcher","foaf:name":[{"@value":"Soichiro Kumagai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048642","@type":"Researcher","foaf:name":[{"@value":"Toyoaki Murohara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232190048517","@type":"Researcher","foaf:name":[{"@value":"Masaya Matsumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751142969344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70426500"},{"@type":"NRID","@value":"1000070426500"},{"@type":"NRID","@value":"9000367055991"},{"@type":"NRID","@value":"9000001811672"},{"@type":"NRID","@value":"9000022055312"},{"@type":"NRID","@value":"9000314382923"},{"@type":"NRID","@value":"9000283493904"},{"@type":"NRID","@value":"9000345256146"},{"@type":"NRID","@value":"9000023997482"},{"@type":"NRID","@value":"9000020163815"},{"@type":"NRID","@value":"9000279910824"},{"@type":"NRID","@value":"9000259832105"},{"@type":"NRID","@value":"9000375849490"},{"@type":"NRID","@value":"9000280547092"},{"@type":"NRID","@value":"9000256911719"},{"@type":"NRID","@value":"9000297498325"},{"@type":"NRID","@value":"9000412196314"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000012724"}],"foaf:name":[{"@value":"Mutsuharu Hayashi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01675273"}],"prism:publicationName":[{"@value":"International Journal of Cardiology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-02","prism:volume":"163","prism:number":"2","prism:startingPage":"214","prism:endingPage":"216"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0167527312008856?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0167527312008856?httpAccept=text/plain"}],"createdAt":"2012-07-11","modifiedAt":"2025-09-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20Artery%20Disease","dc:title":"Coronary Artery Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Carotid%20Intima-Media%20Thickness","dc:title":"Carotid Intima-Media Thickness"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Indican","dc:title":"Indican"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257104250112","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22592322"},{"@type":"JGN","@value":"JP22592322"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592322/"}],"notation":[{"@language":"ja","@value":"歯周病がメタボリックシンドロームに及ぼす直接作用の解析"},{"@language":"en","@value":"Direct involvement of periodontal disease on metabolic syndrome"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1361137045688434432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045851475968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kidney Disease as a Risk Factor for Development of Cardiovascular Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518937107840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975844284344832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of <i>S</i>-Equol, Indoxyl Sulfate, and Trimethylamine <i>N</i>-Oxide on Vascular Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420503638400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Carotid Intima-Media Thickness and Risk of Cardiovascular Events in High-Risk Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370714906112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Statement on authorship and publishing ethics in the international journal of cardiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270187857280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"International Prevalence, Recognition, and Treatment of Cardiovascular Risk Factors in Outpatients With Atherothrombosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1371976229151929987","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Uremic toxicity of indoxyl sulfate"}]},{"@id":"https://cir.nii.ac.jp/crid/1371976229151930112","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204450937600","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"慢性疾患における炎症と血栓―動物モデルを用いた検討"},{"@language":"en","@value":"Breaking the vicious cycle between inflammation and thrombosis in chronic diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205106109440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Plasma Indoxyl Sulfate and Estimated Glomerular Filtration Rate"},{"@value":"Plasma Indoxyl Sulfate and Estimated Glomerular Filtration Rate : Association With Long-Term Clinical Outcome in Patients With Coronary Artery Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390023107065842688","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"慢性疾患におけるPAI-1発現の意義―メタボリック症候群，情動ストレス，慢性腎臓病から老化まで―"},{"@language":"en","@value":"The significance of PAI-1 expression in chronic diseases: from metabolic syndrome, emotional stress and chronic kidney disease to aging"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679426796032","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"尿毒素による腎・血管障害と向血栓傾向"},{"@language":"en","@value":"Uremic toxin-induced nephro-vascular injury and thrombophilia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084058624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of Gut-Derived Protein-Bound Uremic Toxins in Cardiorenal Syndrome and Potential Treatment Modalities"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285697606870272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of Plasma Inositol and Indoxyl Sulfate as Novel Biomarker Candidates for Atherosclerosis in Patients with Type 2 Diabetes. -Findings from Metabolome Analysis Using GC/MS-"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074193578496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equations for estimated GFR from serum creatinine in Japan. American journal of kidney diseases: the official journal of the"},{"@value":"Revised equations for estimating glomerular filtration rate (GFR) from serum creatinine in Japan"},{"@value":"Hishida A; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimating GFR. Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimated GFR"},{"@value":"Japanese equation for estimated GFR"},{"@value":"Revised equation for estimating glomerular filtration rate (GFR) from serum creatinin in Japan"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.ijcard.2012.06.094"},{"@type":"KAKEN","@value":"PRODUCT-13580161"},{"@type":"OPENAIRE","@value":"doi_dedup___::60b7bf2f3c699710a58acd2f22ce819b"},{"@type":"CROSSREF","@value":"10.2491/jjsth.26.597_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"},{"@type":"CROSSREF","@value":"10.2491/jjsth.36.396_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-14-0401_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"},{"@type":"CROSSREF","@value":"10.5551/jat.52506_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"},{"@type":"CROSSREF","@value":"10.2491/jjsth.26.318_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"},{"@type":"CROSSREF","@value":"10.1093/ajh/hpaa053_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-15-0749_references_DOI_9qyp38nciSPtZgW1Ssbd0bq3L6T"}]}