{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232392015872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.neulet.2012.10.060"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304394012014425?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304394012014425?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23142717"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Anti-glutamate receptor ɛ2 antibodies in psychiatric patients with anti-thyroid autoantibodies – A prevalence study in Japan"}],"description":[{"notation":[{"@value":"Patients with anti-thyroid antibodies (ATAs) present various kinds of psychiatric conditions. When these psychiatric patients with ATAs (PPATs) show responsiveness to immunotherapy, they are frequently diagnosed with a diffuse progressive type of Hashimoto's encephalopathy (HE). Anti-glutamate receptor ɛ2 subunit (GluRɛ2) antibodies have previously been reported in HE patients. However, it is unclear whether there is any relationship between PPATs, including HE patients, and anti-GluRɛ2 antibodies. We investigated anti-GluRɛ2 antibodies in the serum and cerebrospinal fluid (CSF) of 15 PPATs, and we compared the results with those of 11 patients with neuropsychiatric systemic lupus erythematosus (NPSLE), an anti-glutamate receptor antibody-related disease. We then compared the neuropsychiatric symptoms between the PPATs with and without anti-GluRɛ2 antibodies. The prevalence of anti-GluRɛ2 antibodies was significantly higher in the CSF than in the serum of PPATs (41.7% versus 6.7%; p=0.040). The prevalence of anti-GluRɛ2 antibodies was slightly higher in the CSF of PPATs than NPSLE patients. PPAT-GluR(+)s showed a significantly higher prevalence of emotional instability (100% versus 33.3%; p=0.03) and also showed a significantly lower prevalence of delusions (0% versus 100%; p=0.001) and hallucinations (17% versus 83%; p=0.038) than PPAT-GluR(-)s. Our results suggest that anti-GluRɛ2 antibodies may be associated with the neuropsychiatric manifestation of PPATs."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232392015873","@type":"Researcher","foaf:name":[{"@value":"Yuhei Chiba"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326231705344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40420674"},{"@type":"NRID","@value":"1000040420674"},{"@type":"NRID","@value":"9000000982464"},{"@type":"NRID","@value":"9000000904591"},{"@type":"NRID","@value":"9000413518087"},{"@type":"NRID","@value":"9000000776140"},{"@type":"NRID","@value":"9000015317741"},{"@type":"NRID","@value":"9000256567569"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000000571"}],"foaf:name":[{"@value":"Omi Katsuse"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232392015876","@type":"Researcher","foaf:name":[{"@value":"Yukitoshi 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Ueda"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276174745984","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50236494"},{"@type":"NRID","@value":"1000050236494"},{"@type":"CINII_AUTHOR_ID","@value":"DB00118449"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DB00118449#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDB00118449"},{"@type":"NRID","@value":"9000003083109"},{"@type":"NRID","@value":"9000001682320"},{"@type":"NRID","@value":"9000412597806"},{"@type":"NRID","@value":"9000020397854"},{"@type":"NRID","@value":"9000399947452"},{"@type":"NRID","@value":"9000410317778"},{"@type":"NRID","@value":"9000399162133"},{"@type":"NRID","@value":"9000261047132"},{"@type":"NRID","@value":"9000345272955"},{"@type":"NRID","@value":"9000001207863"},{"@type":"NRID","@value":"9000021180246"},{"@type":"NRID","@value":"9000265566187"},{"@type":"NRID","@value":"9000003083080"},{"@type":"NRID","@value":"9000003083081"},{"@type":"NRID","@value":"9000005229342"},{"@type":"NRID","@value":"9000021179920"},{"@type":"NRID","@value":"9000020864996"},{"@type":"NRID","@value":"9000002008732"},{"@type":"NRID","@value":"9000412591485"},{"@type":"NRID","@value":"9000353371912"},{"@type":"NRID","@value":"9000000561272"},{"@type":"NRID","@value":"9000010355698"},{"@type":"NRID","@value":"9000019192643"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0031729"}],"foaf:name":[{"@value":"Mitsuhiro Takeno"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658688154880","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20381501"},{"@type":"NRID","@value":"1000020381501"},{"@type":"NRID","@value":"9000000923098"},{"@type":"NRID","@value":"9000018546862"},{"@type":"NRID","@value":"9000266903562"},{"@type":"NRID","@value":"9000010142913"},{"@type":"NRID","@value":"9000007062272"},{"@type":"NRID","@value":"9000356630111"},{"@type":"NRID","@value":"9000363897933"}],"foaf:name":[{"@value":"Takashi Togo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232392015881","@type":"Researcher","foaf:name":[{"@value":"Yoshio Hirayasu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03043940"}],"prism:publicationName":[{"@value":"Neuroscience Letters"}],"dc:publisher":[{"@value":"Elsevier 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