{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232480179072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.reth.2014.11.002"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2352320415000097?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2352320415000097?httpAccept=text/xml"}},{"identifier":{"@type":"PMID","@value":"31245436"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Phosphorus-insufficient maternal milk is associated with ectopic expression of collagen I and female-specific bony changes in infant mouse cartilages"}],"description":[{"notation":[{"@value":"Excessive phosphorus intake causes diseases such as hyperphosphatemia and hypocalcaemia, but the effect of dietary insufficiency of phosphorus is unclear. Here, we explored the effect of phosphorus dietary insufficiency on tissue growth and maintenance by using C57BL/6J mice fed a low phosphorus diet, which contained 18.5% of the phosphorus of a normal diet. We demonstrated that the phosphorus content in the maternal milk of mother mice was significantly reduced due to the consumption of a low phosphorus diet, which further resulted in bone deformation in infant mice in a female-specific manner. Polarizing microscopic analysis of low-phosphorus milk (LPM)-induced bone deformation resulted in unusually formed crystals inside cartilage. Furthermore, immunohistochemical analysis revealed ectopic expression of collagen I in the region where crystals were ectopically formed. Electron microscopic analysis showed morphological features similar to bone tissues. Immunochemical analysis demonstrated that the amount of interleukin-6 (IL-6), a cytokine known to trigger osteoclast formation, was significantly reduced in the maternal milk of mice fed the low-phosphorus diet. Our results suggest that phosphorus intake from maternal milk is involved in infant cartilage formation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232480179075","@type":"Researcher","foaf:name":[{"@value":"Akihiro Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232480179072","@type":"Researcher","foaf:name":[{"@value":"Kenji Miyado"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232480179073","@type":"Researcher","foaf:name":[{"@value":"Michiyo Nasu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232480179076","@type":"Researcher","foaf:name":[{"@value":"Tomohiro Kono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232480179074","@type":"Researcher","foaf:name":[{"@value":"Akihiro Umezawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23523204"}],"prism:publicationName":[{"@value":"Regenerative Therapy"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2015-06","prism:volume":"1","prism:startingPage":"5","prism:endingPage":"10"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2352320415000097?httpAccept=text/plain"},{"@id":"https://api.elsevier.com/content/article/PII:S2352320415000097?httpAccept=text/xml"}],"createdAt":"2015-02-18","modifiedAt":"2019-08-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Medicine%20(General)","dc:title":"Medicine (General)"},{"@id":"https://cir.nii.ac.jp/all?q=QH573-671","dc:title":"QH573-671"},{"@id":"https://cir.nii.ac.jp/all?q=nutritional%20environment","dc:title":"nutritional environment"},{"@id":"https://cir.nii.ac.jp/all?q=maternal%20milk","dc:title":"maternal milk"},{"@id":"https://cir.nii.ac.jp/all?q=bone%20deformation","dc:title":"bone deformation"},{"@id":"https://cir.nii.ac.jp/all?q=R5-920","dc:title":"R5-920"},{"@id":"https://cir.nii.ac.jp/all?q=maternal%20diet","dc:title":"maternal diet"},{"@id":"https://cir.nii.ac.jp/all?q=Original%20Article","dc:title":"Original Article"},{"@id":"https://cir.nii.ac.jp/all?q=phosphorus","dc:title":"phosphorus"},{"@id":"https://cir.nii.ac.jp/all?q=Cytology","dc:title":"Cytology"},{"@id":"https://cir.nii.ac.jp/all?q=female-specific%20manner","dc:title":"female-specific manner"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782437956480","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"13J07513"},{"@type":"JGN","@value":"JP13J07513"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13J07513/"}],"notation":[{"@language":"ja","@value":"哺乳類における無機ポリリン酸の役割とＡＴＰ産生における代替経路に関する研究"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145153561344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145564005504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increasing serum calcium and magnesium concentrations in breast-fed infants: Longitudinal studies of minerals in human milk and in sera of nursing mothers and their infants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621143619328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endochondral ossification: How cartilage is converted into bone in the developing skeleton"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657410318080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Breast milk stimulates growth hormone secretion in infant mice, and phosphorus insufficiency disables this ability and causes dwarfism-like symptoms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569439958912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection of IL-6 in human milk and its involvement in IgA production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570895589632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selected Macro/Micronutrient Needs of the Routine Preterm Infant"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044990465792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokines regulating osteoclast formation and function"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045711876224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor Necrosis Factor-α (TNF) Stimulates RANKL-induced Osteoclastogenesis via Coupling of TNF Type 1 Receptor and RANK Signaling 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