{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004232525963392.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.tetasy.2013.01.019"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0957416613000414?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0957416613000414?httpAccept=text/plain"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Research on the pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters"}],"description":[{"notation":[{"@value":"Abstract   The pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters is described. Generally, the PLE-catalyzed enantioselective hydrolysis of prochiral diesters affords the corresponding half-esters in high yield, because further hydrolysis of the half-esters does not typically occur. However, we found that some half-esters undergo PLE-catalyzed hydrolysis when they are gradually added to a PLE suspension in a potassium phosphate buffer at pH 8.0 via a syringe pump, leading to the kinetic resolution of the half-esters."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004232525963393","@type":"Researcher","foaf:name":[{"@value":"Naoyoshi Noguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232525963394","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro Tsuna"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004232525963392","@type":"Researcher","foaf:name":[{"@value":"Masahisa Nakada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09574166"}],"prism:publicationName":[{"@value":"Tetrahedron: Asymmetry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-04","prism:volume":"24","prism:number":"7","prism:startingPage":"357","prism:endingPage":"361"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0957416613000414?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0957416613000414?httpAccept=text/plain"}],"createdAt":"2013-04-08","modifiedAt":"2025-10-17","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782062492800","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21106001"},{"@type":"JGN","@value":"JP21106001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-21106001/"}],"notation":[{"@language":"ja","@value":"反応集積化の合成化学　革新的手法の開拓と有機物質創成への展開"},{"@language":"en","@value":"Organic Synthesis Based on Reaction Integration. Development of New Methods and Creation of New Substances"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782062530432","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21106009"},{"@type":"JGN","@value":"JP21106009"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21106009/"}],"notation":[{"@language":"ja","@value":"立体選択的タンデム反応の開発と生物活性物質の集積合成への活用"},{"@language":"en","@value":"Synthetic Studies on Bioactive Natural Products utilizing Integrated"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143882312448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enzyme catalysed hydrolysis of dialkylated propanedioic acid diesters, chain length dependent reversal of enantioselectivity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144628074496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145603920896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145875237760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biocatalytic Methods for the Synthesis of Enantioenriched Odor Active Compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146214214144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enantioselective Synthesis of α-Quaternary Amino Acid Derivatives by Sequential Enzymatic Desymmetrization and Curtius Rearrangement of α,α-Disubstituted Malonate Diesters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146241841152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effect of dimethyl sulfoxide on the enantioselectivity in the pig liver esterase catalyzed hydrolysis of dialkylated propanedioic acid dimethyl esters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146339943808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Introduction to Enzymes in Synthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619022073216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enantioselective hydrolysis of dialkyl 3-monosubstituted glutarates with pig liver esterase: Structure-optical purity relationships"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621081379968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A New Catalyst for a Pd Catalyzed Alder Ene Reaction. 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