{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233127564288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.jafc.8b04138"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.8b04138"}},{"identifier":{"@type":"PMID","@value":"30426751"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Resveratrol Ameliorates Intestinal Barrier Defects and Inflammation in Colitic Mice and Intestinal Cells"}],"description":[{"notation":[{"@value":"This study is aimed to investigate the ameliorative effect of resveratrol in a dextran sodium sulfate (DSS)-induced colitis mouse model and intestinal Caco-2 cells, focusing on neutrophil infiltration and tight junction (TJ) barriers. DSS administration caused body weight loss (day8, control 104 ± 1, DSS 72 ± 2%, p0.05), shortening of colon length (control 5.1 ± 0.1, DSS 3.8 ± 0.1 cm, p0.05), pro-inflammatory cytokines increase-including interleukin (IL)-1β (control 1.0 ± 0.2, DSS 58.5 ± 29.6 arbitrary unit (AU), p0.05), IL-6 (control 1.0 ± 0.3, DSS 312 ± 82 AU, p0.05), and chemokine motif ligand 2 (CXCL-2, a murine IL-8 homologue, control 1.0 ± 0.4, DSS 696 ± 262 AU, p0.05), decreased TJ proteins (e.g., occludin, control 1.0 ± 0.05, DSS 0.11 ± 0.03 AU, p0.05), and neutrophil infiltration (control 1.2 ± 0.2, DSS 25.9 ± 1.1 cells, p0.05). Supplemental resveratrol (0.1% (w/w) in the diet) partially or totally reversed these symptoms (body weight change 100 ± 1, colon length 4.6 ± 0.1; IL-1β 5.9 ± 1.8, IL-6 10 ± 3, CXCL-2 14 ± 7, occludin 0.76 ± 0.06, neutrophil infiltration 9.3 ± 0.7, p0.05). Pretreatment of intestinal Caco-2 cells with resveratrol suppressed the TNF-α-induced production of IL-8 (control 1.00 ± 0.04, TNFα 3.40 ± 0.16, TNFα+Res 1.81 ± 0.28 AU, p0.05) and phosphorylation of the inflammatory signaling molecules including NF-κB, extracellular signal-regulated kinase and stress c-Jun N-terminal protein kinase. Collectively, the reduction of TJ barrier defect and IL-8 in intestinal cells, leading to reduced neutrophil infiltration into colonic tissues, appears to be one of the central mechanisms for the resveratrol-mediated effect."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233127564289","@type":"Researcher","foaf:name":[{"@value":"Yunika Mayangsari"}],"jpcoar:affiliationName":[{"@value":"Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Kagamiyama, Higashi Hiroshima City 739-8528, Japan"},{"@value":"Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Gadjah Mada, Sleman, Yogyakarta 55281, Indonesia"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801185256448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30526695"},{"@type":"NRID","@value":"1000030526695"},{"@type":"NRID","@value":"9000283846502"},{"@type":"NRID","@value":"9000016893492"},{"@type":"NRID","@value":"9000267793614"},{"@type":"NRID","@value":"9000019090019"},{"@type":"NRID","@value":"9000016926570"},{"@type":"NRID","@value":"9000018142586"},{"@type":"NRID","@value":"9000258518628"},{"@type":"NRID","@value":"9000259322098"},{"@type":"NRID","@value":"9000257924060"},{"@type":"NRID","@value":"9000242575934"},{"@type":"NRID","@value":"9000299561381"},{"@type":"NRID","@value":"9000257755327"},{"@type":"NRID","@value":"9000258518618"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takuya-s"}],"foaf:name":[{"@value":"Takuya Suzuki"}],"jpcoar:affiliationName":[{"@value":"Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Kagamiyama, Higashi Hiroshima City 739-8528, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00218561"},{"@type":"EISSN","@value":"15205118"}],"prism:publicationName":[{"@value":"Journal of Agricultural and Food Chemistry"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2018-11-14","prism:volume":"66","prism:number":"48","prism:startingPage":"12666","prism:endingPage":"12674"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.8b04138"}],"createdAt":"2018-11-14","modifiedAt":"2023-04-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Necrosis%20Factor-alpha","dc:title":"Tumor Necrosis Factor-alpha"},{"@id":"https://cir.nii.ac.jp/all?q=Dextran%20Sulfate","dc:title":"Dextran Sulfate"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-1beta","dc:title":"Interleukin-1beta"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Colitis","dc:title":"Colitis"},{"@id":"https://cir.nii.ac.jp/all?q=Tight%20Junctions","dc:title":"Tight Junctions"},{"@id":"https://cir.nii.ac.jp/all?q=Intestines","dc:title":"Intestines"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Neutrophil%20Infiltration","dc:title":"Neutrophil 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