{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233130163456.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.jnatprod.8b00101"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.8b00101"}},{"identifier":{"@type":"PMID","@value":"29613787"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Miuramides A and B, Trisoxazole Macrolides from a <i>Mycale</i> sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells"}],"description":[{"notation":[{"@value":"Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent cytotoxicity against 3Y1 cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233130163459","@type":"Researcher","foaf:name":[{"@value":"Rei Suo"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751167377792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90455353"},{"@type":"NRID","@value":"1000090455353"},{"@type":"NRID","@value":"9000311788494"},{"@type":"NRID","@value":"9000006709261"},{"@type":"NRID","@value":"9000410897869"},{"@type":"NRID","@value":"9000243766422"},{"@type":"NRID","@value":"9000318135508"},{"@type":"NRID","@value":"9000396103494"},{"@type":"NRID","@value":"9000403021789"},{"@type":"NRID","@value":"9000305630933"},{"@type":"NRID","@value":"9000248225634"},{"@type":"NRID","@value":"9000398274750"},{"@type":"NRID","@value":"9000264264370"},{"@type":"NRID","@value":"9000325464853"},{"@type":"NRID","@value":"9000262362209"},{"@type":"NRID","@value":"9000019244067"},{"@type":"NRID","@value":"9000404105082"},{"@type":"NRID","@value":"9000402399237"},{"@type":"NRID","@value":"9000272256725"},{"@type":"NRID","@value":"9000383838634"},{"@type":"NRID","@value":"9000301712949"},{"@type":"NRID","@value":"9000001882509"},{"@type":"NRID","@value":"9000243751462"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/KentaroTakada"}],"foaf:name":[{"@value":"Kentaro Takada"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233130163458","@type":"Researcher","foaf:name":[{"@value":"Hisanori Kohtsuka"}],"jpcoar:affiliationName":[{"@value":"Misaki Marine Biological Station (MMBS), Graduate School of Science and Center for Marine Biology, The University of Tokyo, Misaki, Miura, Kanagawa 238-0225, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233130163456","@type":"Researcher","foaf:name":[{"@value":"Yuji Ise"}],"jpcoar:affiliationName":[{"@value":"Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Toba, Mie 517-0004, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233130163457","@type":"Researcher","foaf:name":[{"@value":"Shigeru Okada"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233130163460","@type":"Researcher","foaf:name":[{"@value":"Shigeki Matsunaga"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01633864"},{"@type":"EISSN","@value":"15206025"}],"prism:publicationName":[{"@value":"Journal of Natural Products"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2018-04-03","prism:volume":"81","prism:number":"4","prism:startingPage":"1108","prism:endingPage":"1112"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.8b00101"}],"createdAt":"2018-04-03","modifiedAt":"2023-04-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mammals","dc:title":"Mammals"},{"@id":"https://cir.nii.ac.jp/all?q=Cytotoxins","dc:title":"Cytotoxins"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Porifera","dc:title":"Porifera"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Macrolides","dc:title":"Macrolides"},{"@id":"https://cir.nii.ac.jp/all?q=Oxazoles","dc:title":"Oxazoles"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781900459136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H04980"},{"@type":"JGN","@value":"JP16H04980"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04980/"}],"notation":[{"@language":"ja","@value":"海綿動物の生活環に基づいた有用微生物による天然物生産機構の解明"},{"@language":"en","@value":"Identification of biosynthetic gene clusters of bioactive natural products and their producing bacteria  based on sponges life cycle"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256882098176","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16J07837"},{"@type":"JGN","@value":"JP16J07837"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J07837/"}],"notation":[{"@language":"ja","@value":"海洋生物からのエンドサイトーシスを標的とした活性物質の探索および作用機序の解明"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256936393344","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H06403"},{"@type":"JGN","@value":"JP17H06403"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06403/"}],"notation":[{"@language":"ja","@value":"カイメン―共生微生物間化学コミュニケーションの解析と有用共生微生物の可培養化"},{"@language":"en","@value":"Analysis of chemical communication between sponge and its symbionts and attempts to cultivate productive symbionts"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144131286016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Actin-targeting natural products: structures, properties and mechanisms of action"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144910017408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Trisoxazole Macrolides from Hexabranchus Nudibranchs and Other Marine Invertebrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618955560192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Drug Discovery from Nature"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182004032384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096387600256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bioactive marine metabolites IX. Mycalisines A and B, novel nucleosides which inhibit cell division of fertilized starfish eggs, from the marine sponge sp."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518697141760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994130608896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New anti-actin drugs in the study of the organization and function of the actin cytoskeleton"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994570517120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mycalolides A – C, hybrid macrolides of ulapualides and halichondramide, from a sponge of the genus"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470100319104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoids"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845881838336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bioactive marine metabolites.  Part 13.  Kabiramide C, a novel antifungal macrolide from nudibranch eggmasses"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321035939968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793628971136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relative and Absolute Stereochemistry of Mycalolides, Bioactive Macrolides from the Marine Sponge <i>Mycale </i><i>m</i><i>agellanica</i><sup>1</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796003192704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390016107123757184","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"1.　Search for bioactive natural products from marine organisms"},{"@language":"ja","@value":"1.　海洋生物からのモノトリ研究"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679671097344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cellular Changes of Rat Embryonic Fibroblasts by an Actin-Polymerization Inhibitor, Bistheonellide A, from a Marine Sponge."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1021/acs.jnatprod.8b00101"},{"@type":"KAKEN","@value":"PRODUCT-23642229"},{"@type":"KAKEN","@value":"PRODUCT-21809510"},{"@type":"KAKEN","@value":"PRODUCT-23135153"},{"@type":"OPENAIRE","@value":"doi_dedup___::a91dffc9084192b91dbfb01c080c066b"},{"@type":"CROSSREF","@value":"10.2331/suisan.wa3061-1_references_DOI_QebAdKSmSCAkSWTQkKci9pYyVzm"}]}