{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233139638784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.molpharmaceut.7b01122"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b01122"}},{"identifier":{"@type":"PMID","@value":"29502422"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Morphological and Physicochemical Evaluation of Two Distinct Glibenclamide/Hypromellose Amorphous Nanoparticles Prepared by the Antisolvent Method"}],"description":[{"notation":[{"@value":"The morphology and stability of amorphous nanoparticles of glibenclamide (GLB) prepared by the antisolvent method using different methods of adding hypromellose (HPMC) were evaluated. Nano-A was prepared by the injection of a dimethyl sulfoxide (DMSO) solution of GLB into the HPMC solution, whereas nano-B was obtained by the injection of a DMSO solution of GLB and HPMC into water. Cryogenic transmission electron microscopy, field-emission scanning electron microscopy, and field-emission transmission electron microscopy, including energy dispersive X-ray spectrometry, revealed that the particles of the nano-A and nano-B samples are hollow spheres and nonspherical nanoparticles, respectively. Powder X-ray diffraction and solid-state NMR measurements showed that GLB is present in an amorphous state in both nano-A and nano-B. The weight ratios of HPMC in the GLB/HPMC nanoparticles were 11 and 16% for nano-A and nano-B, respectively, as determined by solution-state NMR. The glass transition temperatures ( T"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233139638791","@type":"Researcher","foaf:name":[{"@value":"Hazuki Yonashiro"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326231759360","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40451760"},{"@type":"NRID","@value":"1000040451760"},{"@type":"NRID","@value":"9000006887097"},{"@type":"NRID","@value":"9000019214517"},{"@type":"NRID","@value":"9000356653610"},{"@type":"NRID","@value":"9000254255409"},{"@type":"NRID","@value":"9000399519089"},{"@type":"NRID","@value":"9000411478837"},{"@type":"NRID","@value":"9000020802145"},{"@type":"NRID","@value":"9000398138177"},{"@type":"NRID","@value":"9000403427693"},{"@type":"NRID","@value":"9000259320679"},{"@type":"NRID","@value":"9000021097728"},{"@type":"NRID","@value":"9000317157601"},{"@type":"NRID","@value":"9000404099699"},{"@type":"NRID","@value":"9000415086182"},{"@type":"NRID","@value":"9000405924231"},{"@type":"NRID","@value":"9000243903835"},{"@type":"NRID","@value":"9000334744110"},{"@type":"NRID","@value":"9000322100983"},{"@type":"NRID","@value":"9000296662759"},{"@type":"NRID","@value":"9000020526709"},{"@type":"NRID","@value":"9000283259717"},{"@type":"NRID","@value":"9000327451101"},{"@type":"NRID","@value":"9000406216362"},{"@type":"NRID","@value":"9000412422852"},{"@type":"NRID","@value":"9000021595861"},{"@type":"NRID","@value":"9000258225224"},{"@type":"NRID","@value":"9000264264547"},{"@type":"NRID","@value":"9000409166179"},{"@type":"NRID","@value":"9000409788879"},{"@type":"NRID","@value":"9000006711556"},{"@type":"NRID","@value":"9000020055832"},{"@type":"NRID","@value":"9000398132203"},{"@type":"NRID","@value":"9000258419415"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kenjirouhigashi"}],"foaf:name":[{"@value":"Kenjirou Higashi"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638790","@type":"Researcher","foaf:name":[{"@value":"Chikako Morikawa"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638785","@type":"Researcher","foaf:name":[{"@value":"Keisuke Ueda"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638786","@type":"Researcher","foaf:name":[{"@value":"Tsutomu Itoh"}],"jpcoar:affiliationName":[{"@value":"Center for Analytical Instrumentation, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638789","@type":"Researcher","foaf:name":[{"@value":"Masataka Ito"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638787","@type":"Researcher","foaf:name":[{"@value":"Hyuma Masu"}],"jpcoar:affiliationName":[{"@value":"Center for Analytical Instrumentation, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638784","@type":"Researcher","foaf:name":[{"@value":"Shuji Noguchi"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139638792","@type":"Researcher","foaf:name":[{"@value":"Kunikazu Moribe"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15438384"},{"@type":"EISSN","@value":"15438392"}],"prism:publicationName":[{"@value":"Molecular Pharmaceutics"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2018-03-05","prism:volume":"15","prism:number":"4","prism:startingPage":"1587","prism:endingPage":"1597"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b01122"}],"createdAt":"2018-03-05","modifiedAt":"2023-04-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Calorimetry,%20Differential%20Scanning","dc:title":"Calorimetry, Differential Scanning"},{"@id":"https://cir.nii.ac.jp/all?q=Water","dc:title":"Water"},{"@id":"https://cir.nii.ac.jp/all?q=Gas%20Chromatography-Mass%20Spectrometry","dc:title":"Gas Chromatography-Mass Spectrometry"},{"@id":"https://cir.nii.ac.jp/all?q=Hypromellose%20Derivatives","dc:title":"Hypromellose Derivatives"},{"@id":"https://cir.nii.ac.jp/all?q=Solubility","dc:title":"Solubility"},{"@id":"https://cir.nii.ac.jp/all?q=X-Ray%20Diffraction","dc:title":"X-Ray Diffraction"},{"@id":"https://cir.nii.ac.jp/all?q=Glyburide","dc:title":"Glyburide"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Electron,%20Scanning","dc:title":"Microscopy, Electron, Scanning"},{"@id":"https://cir.nii.ac.jp/all?q=Solvents","dc:title":"Solvents"},{"@id":"https://cir.nii.ac.jp/all?q=Nanoparticles","dc:title":"Nanoparticles"},{"@id":"https://cir.nii.ac.jp/all?q=Dimethyl%20Sulfoxide","dc:title":"Dimethyl Sulfoxide"},{"@id":"https://cir.nii.ac.jp/all?q=Powders","dc:title":"Powders"},{"@id":"https://cir.nii.ac.jp/all?q=Crystallization","dc:title":"Crystallization"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256976431744","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K06592"},{"@type":"JGN","@value":"JP18K06592"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06592/"}],"notation":[{"@language":"ja","@value":"超難水溶性薬物の製剤化を実現する薬物非晶質ナノ懸濁液の創製"},{"@language":"en","@value":"Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drug"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233139722112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid 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