{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233139722112.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.molpharmaceut.9b00158"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00158"}},{"identifier":{"@type":"PMID","@value":"30925218"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid Dispersions"}],"description":[{"notation":[{"@value":"In this study, the time-dependent evolution of amorphous probucol nanoparticles was characterized by cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM). The nanoparticles were formed by dispersing ternary solid dispersions of probucol in water. Spray drying and cogrinding were used to prepare a spray-dried sample (SPD) and two ground-mixture samples (GM(I) and GM(II)) of probucol (PBC) form I and form II/hypromellose/sodium dodecyl sulfate ternary solid dispersions. The amorphization of PBC in the SPDs and GMs was confirmed using powder X-ray diffraction (PXRD) and solid-state"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233139722241","@type":"Researcher","foaf:name":[{"@value":"Zhijing Zhao"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139722240","@type":"Researcher","foaf:name":[{"@value":"Hiroaki Katai"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, 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Chuo-ku, Chiba 260-8675, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233139722113","@type":"Researcher","foaf:name":[{"@value":"Kohsaku Kawakami"}],"jpcoar:affiliationName":[{"@value":"International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, 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Transmission"},{"@id":"https://cir.nii.ac.jp/all?q=Solubility","dc:title":"Solubility"},{"@id":"https://cir.nii.ac.jp/all?q=Suspensions","dc:title":"Suspensions"},{"@id":"https://cir.nii.ac.jp/all?q=X-Ray%20Diffraction","dc:title":"X-Ray Diffraction"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Design","dc:title":"Drug Design"},{"@id":"https://cir.nii.ac.jp/all?q=Nanoparticles","dc:title":"Nanoparticles"},{"@id":"https://cir.nii.ac.jp/all?q=Particle%20Size","dc:title":"Particle Size"},{"@id":"https://cir.nii.ac.jp/all?q=Crystallization","dc:title":"Crystallization"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782022820352","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K16334"},{"@type":"JGN","@value":"JP19K16334"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16334/"}],"notation":[{"@language":"ja","@value":"NMRを用いた分子状態評価に基づく薬物濃縮相形成型固体分散体製剤の開発"},{"@language":"en","@value":"Development of drug-rich phase-forming solid dispersion 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