{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233142230528.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.orglett.7b00318"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.7b00318"}},{"identifier":{"@type":"PMID","@value":"28256141"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from <i>Actinomadura</i> sp."}],"description":[{"notation":[{"@value":"Nonthmicin (1), a new polyether polyketide bearing a chlorinated tetronic acid, was isolated from the culture extract of a soil-derived Actinomadura strain. The structure of 1 was elucidated by interpretation of NMR and MS spectroscopic data, and the absolute configuration of 1 was proposed on the basis of the crystal structure of its dechloro congener ecteinamycin (2) also isolated from the same strain. Tetronic acids modified by halogenation have never been reported from natural products. Compounds 1 and 2 were found to have neuroprotective activity and antimetastatic properties at submicromolar concentrations in addition to antibacterial activity."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233142230535","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Igarashi"}],"jpcoar:affiliationName":[{"@value":"Biotechnology\rResearch Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233142230532","@type":"Researcher","foaf:name":[{"@value":"Noriaki Matsuoka"}],"jpcoar:affiliationName":[{"@value":"Biotechnology\rResearch Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233142230529","@type":"Researcher","foaf:name":[{"@value":"Yasuko In"}],"jpcoar:affiliationName":[{"@value":"Department\rof Physical Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1041, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233142230528","@type":"Researcher","foaf:name":[{"@value":"Tetsushi Kataura"}],"jpcoar:affiliationName":[{"@value":"Bioscience\rand Informatics, Keio University, Yokohama, Kanagawa 223-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146115968","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00365446"},{"@type":"NRID","@value":"1000000365446"},{"@type":"NRID","@value":"9000261671022"},{"@type":"NRID","@value":"9000000698762"},{"@type":"NRID","@value":"9000398801597"},{"@type":"NRID","@value":"9000001680547"},{"@type":"NRID","@value":"9000258727326"},{"@type":"NRID","@value":"9000019145425"},{"@type":"NRID","@value":"9000259322065"},{"@type":"NRID","@value":"9000006709866"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0164469"}],"foaf:name":[{"@value":"Etsu Tashiro"}],"jpcoar:affiliationName":[{"@value":"Bioscience\rand Informatics, Keio University, Yokohama, 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