{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233448876288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/nri.2017.142"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nri.2017.142.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nri.2017.142"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/doifinder/10.1038/nri.2017.142"}},{"identifier":{"@type":"PMID","@value":"29379212"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"NF-κB, inflammation, immunity and cancer: coming of age"}],"description":[{"notation":[{"@value":"Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276160981376","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20627020"},{"@type":"NRID","@value":"1000020627020"}],"foaf:name":[{"@value":"Koji Taniguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233448875009","@type":"Researcher","foaf:name":[{"@value":"Michael Karin"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14741733"},{"@type":"EISSN","@value":"14741741"}],"prism:publicationName":[{"@value":"Nature Reviews Immunology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2018-01-22","prism:volume":"18","prism:number":"5","prism:startingPage":"309","prism:endingPage":"324"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/nri.2017.142.pdf"},{"@id":"http://www.nature.com/articles/nri.2017.142"},{"@id":"http://www.nature.com/doifinder/10.1038/nri.2017.142"}],"createdAt":"2018-01-22","modifiedAt":"2023-05-19","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Immunological","dc:title":"Models, Immunological"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Fibroblasts","dc:title":"Fibroblasts"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy","dc:title":"Autophagy"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplastic%20Stem%20Cells","dc:title":"Neoplastic Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Microenvironment","dc:title":"Tumor Microenvironment"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Myeloid%20Cells","dc:title":"Myeloid Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocytes","dc:title":"Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokines","dc:title":"Chemokines"},{"@id":"https://cir.nii.ac.jp/all?q=Cellular%20Senescence","dc:title":"Cellular Senescence"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781867183232","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K21775"},{"@type":"JGN","@value":"JP15K21775"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21775/"}],"notation":[{"@language":"ja","@value":"消化器癌と消化器再生における炎症の役割の解明"},{"@language":"en","@value":"Study on the role of inflammation in gastrointestinal cancer and regeneration"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050022853111987328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Flavinated SDHA underlies the change in intrinsic optical properties of oral cancers."}]},{"@id":"https://cir.nii.ac.jp/crid/1050282814244639360","@type":"Article","resourceType":"学術雑誌論文(journal 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