{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233465736192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-017-01922-5"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-017-01922-5.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-017-01922-5"}},{"identifier":{"@type":"PMID","@value":"29170512"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Animal fetuses and embryos may have applications in the generation of human organs. Progenitor cells may be an appropriate cell source for regenerative organs because of their safety and availability. However, regenerative organs derived from exogenous lineage progenitors in developing animal fetuses have not yet been obtained. Here, we established a combination system through which donor cells could be precisely injected into the nephrogenic zone and native nephron progenitor cells (NPCs) could be eliminated in a time- and tissue-specific manner. We successfully achieved removal of Six2+ NPCs within the nephrogenic niche and complete replacement of transplanted NPCs with donor cells. These NPCs developed into mature glomeruli and renal tubules, and blood flow was observed following transplantation in vivo. Furthermore, this artificial nephron could be obtained using NPCs from different species. Thus, this technique enables in vivo differentiation from progenitor cells into nephrons, providing insights into nephrogenesis and organ regeneration.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233465735826","@type":"Researcher","foaf:name":[{"@value":"S. Yamanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465736075","@type":"Researcher","foaf:name":[{"@value":"S. Tajiri"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465736198","@type":"Researcher","foaf:name":[{"@value":"T. Fujimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465735808","@type":"Researcher","foaf:name":[{"@value":"K. Matsumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465735813","@type":"Researcher","foaf:name":[{"@value":"S. Fukunaga"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465735680","@type":"Researcher","foaf:name":[{"@value":"B. S. Kim"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465736199","@type":"Researcher","foaf:name":[{"@value":"H. J. Okano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233465736200","@type":"Researcher","foaf:name":[{"@value":"T. Yokoo"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-11-23","prism:volume":"8","prism:number":"1","prism:startingPage":"1719"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-017-01922-5.pdf"},{"@id":"https://www.nature.com/articles/s41467-017-01922-5"}],"createdAt":"2017-11-17","modifiedAt":"2024-06-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Transplantation%20Chimera","dc:title":"Transplantation Chimera"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Organogenesis","dc:title":"Organogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Nephrons","dc:title":"Nephrons"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Mesoderm","dc:title":"Mesoderm"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Species%20Specificity","dc:title":"Species Specificity"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Transgenic","dc:title":"Rats, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cell%20Transplantation","dc:title":"Stem Cell Transplantation"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781915341184","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K09630"},{"@type":"JGN","@value":"JP16K09630"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09630/"}],"notation":[{"@language":"ja","@value":"臓器ニッチを用いたヒトiPS細胞から腎への分化誘導法の開発"},{"@language":"en","@value":"Development of a method to induce differentiation from human iPS cells to the kidney using organ niches"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256945349504","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K09766"},{"@type":"JGN","@value":"JP17K09766"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09766/"}],"notation":[{"@language":"ja","@value":"RNA代謝異常を指標にしたALSバイオマーカーの確立"},{"@language":"en","@value":"Establishment of RNA-based Biomarkers for ALS"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256949779968","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K16102"},{"@type":"JGN","@value":"JP17K16102"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16102/"}],"notation":[{"@language":"ja","@value":"薬剤誘導細胞除去システムを用いた新たな腎再生技術の開発とiPS細胞への応用"},{"@language":"en","@value":"Development of a new kidney regeneration method using a drug-induced cell elimination system for iPS cell derived progenitor cells"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142698087424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"In vivo regeneration of neo-nephrons in rodents by renal progenitor cell transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142901442944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tissue-Engineering Approach to Making Soft Actuators"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144015175936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144698293888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Patterning a Complex Organ: Branching Morphogenesis and Nephron 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fragile renal organoids transplantation in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864796630144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"3D Printing in Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306904414944000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Generation of human-pig chimeric renal organoids using iPSC technology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906070005888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Life-supporting functional kidney replacement by integration of embryonic metanephros-bladder composite tissue transplants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165805689216","@type":"Article","resourceType":"学術雑誌論文(journal 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Cells in Blastocyst Complementation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169779486080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Induced Pluripotent Stem Cell–Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181955485568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Optimal route of diphtheria toxin administration to eliminate native nephron progenitor cells in vivo for kidney regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568467257646464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst 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vimentin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571516887552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Integration of human mesenchymal stem cells into the Wolffian duct in chicken embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593750602240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815684213376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Advances and challenges toward developing kidney organoids for clinical applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045418984576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Number of Fetal Nephron Progenitor Cells Limits Ureteric Branching and Adult Nephron Endowment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045546158464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519573330048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Thermoreversible Polymer Mediates Controlled Release of Glial Cell Line‐Derived Neurotrophic Factor to Enhance Kidney Regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521441094784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Improving our resolution of kidney morphogenesis across time and space"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694366531990016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesangial cell regeneration from exogenous stromal progenitor by utilizing embryonic kidney"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995995541376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996427027840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470379546624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470529651968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943353281792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943864881408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dissociation of Embryonic Kidney Followed by Re-aggregation as a Method for Chimeric Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945146841728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945147302912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Human Podocytes Generated in Organoids 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