{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233471204352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41536-019-0069-4"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41536-019-0069-4.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41536-019-0069-4"}},{"identifier":{"@type":"PMID","@value":"30820353"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these in in vitro and in vivo preclinical studies, and have reported that the transplantation of chondrocyte sheets promoted hyaline cartilage repair in rat, rabbit, and minipig models. However, autologous transplantation of chondrocyte sheets has yet to be reported in humans. Here, we report our combination therapy in which conventional surgical treatment for OAK, is followed by autologous chondrocyte sheet transplantation for cartilage repair. Eight patients with OAK and cartilage defects categorized arthroscopically as Outerbridge grade III or IV receive the therapy. Patients are thoroughly assessed by preoperative and postoperative X-rays, magnetic resonance imaging (MRI), arthroscopy, Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score (LKS), and a laser-induced photoacoustic method to assess cartilage viscoelasticity. Arthroscopic biopsies of all patients are performed 12 months after transplantation for histological evaluation. The properties of the chondrocyte sheets are evaluated using gene expression analysis to investigate the ability to predict the clinical and structural outcomes of the therapy. For this small initial longitudinal series, combination therapy is effective, as assessed by MRI, arthroscopy, viscoelasticity, histology, and the clinical outcomes of KOOS and LKS. Gene marker sets identified in autologous chondrocyte sheets may be predictive of the overall KOOS, LKS, and histological scores after therapy. These predictive gene sets may be potential alternative markers for evaluating OAK treatment.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751146887424","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10056335"},{"@type":"NRID","@value":"1000010056335"},{"@type":"NRID","@value":"9000000919718"},{"@type":"NRID","@value":"9000242348761"},{"@type":"NRID","@value":"9000404807142"},{"@type":"NRID","@value":"9000242114369"},{"@type":"NRID","@value":"9000242563408"},{"@type":"NRID","@value":"9000403433402"},{"@type":"NRID","@value":"9000356639610"},{"@type":"NRID","@value":"9000303922865"},{"@type":"NRID","@value":"9000387366322"},{"@type":"NRID","@value":"9000398959096"},{"@type":"NRID","@value":"9000405684343"},{"@type":"NRID","@value":"9000410171513"},{"@type":"NRID","@value":"9000401723020"},{"@type":"NRID","@value":"9000330330255"},{"@type":"NRID","@value":"9000107356579"},{"@type":"NRID","@value":"9000396168945"},{"@type":"NRID","@value":"9000257901857"},{"@type":"NRID","@value":"9000388473127"},{"@type":"NRID","@value":"9000356670054"},{"@type":"NRID","@value":"9000406193516"},{"@type":"NRID","@value":"9000399165515"},{"@type":"NRID","@value":"9000414346057"},{"@type":"NRID","@value":"9000001512833"},{"@type":"NRID","@value":"9000016665689"},{"@type":"NRID","@value":"9000411086534"},{"@type":"NRID","@value":"9000402612928"},{"@type":"NRID","@value":"9000397847970"},{"@type":"NRID","@value":"9000363279725"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0165245"}],"foaf:name":[{"@value":"Masato Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471203969","@type":"Researcher","foaf:name":[{"@value":"Masayuki Yamato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204232","@type":"Researcher","foaf:name":[{"@value":"Genya Mitani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204110","@type":"Researcher","foaf:name":[{"@value":"Tomonori Takagaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204353","@type":"Researcher","foaf:name":[{"@value":"Kosuke Hamahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204354","@type":"Researcher","foaf:name":[{"@value":"Yoshihiko Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204107","@type":"Researcher","foaf:name":[{"@value":"Miya Ishihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204233","@type":"Researcher","foaf:name":[{"@value":"Ryo Matoba"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204229","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204227","@type":"Researcher","foaf:name":[{"@value":"Teruo Okano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204096","@type":"Researcher","foaf:name":[{"@value":"Joji Mochida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233471204099","@type":"Researcher","foaf:name":[{"@value":"Masahiko Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20573995"}],"prism:publicationName":[{"@value":"npj Regenerative Medicine"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2019-02-21","prism:volume":"4","prism:number":"1","prism:startingPage":"4"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41536-019-0069-4.pdf"},{"@id":"https://www.nature.com/articles/s41536-019-0069-4"}],"createdAt":"2019-02-21","modifiedAt":"2022-12-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256878028672","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H05455"},{"@type":"JGN","@value":"JP16H05455"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05455/"}],"notation":[{"@language":"ja","@value":"網羅的タンパク質解析法を用いた硝子軟骨再生因子の同定"},{"@language":"en","@value":"A comprehensive proteomic analysis for the Identification of factors contributing to hyaline cartilage regeneration"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050014404356143744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A novel chondrocyte sheet fabrication using human-induced pluripotent stem cell-derived expandable limb-bud mesenchymal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215475228032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arthroscopic Transplantation of Synovial Stem Cells Improves Clinical Outcomes in Knees With Cartilage Defects"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231266508800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a 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irradiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945326530688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: Determination of interobserver variability and correlation to clinical outcome after 2 years"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418986789888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cartilage repair in transplanted scaffold-free chondrocyte sheets using a minipig model"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894011050240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Is osteoarthritis a heterogeneous disease that can be stratified into subsets?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894371302144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Osteophytes and progression of 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goats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319072315648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320122208000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A novel recovery system for cultured cells using plasma‐treated polystyrene dishes grafted with poly(N‐isopropylacrylamide)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321306005376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural History of Knee Cartilage Defects and Factors Affecting Change"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794165389056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of a diagnostic system for osteoarthritis using a photoacoustic measurement method"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795400477184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bioengineered chondrocyte sheets may be potentially useful for the treatment of partial thickness defects of articular cartilage"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270566814848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thermo-Responsive Culture Dishes Allow the Intact Harvest of Multilayered Keratinocyte Sheets without Dispase by Reducing Temperature"}]},{"@id":"https://cir.nii.ac.jp/crid/1390020364633497728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of mechanical vibrations on chondrocytes in monolayer culture for regenerative cartilage"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282752350736640","@type":"Article","resourceType":"学術雑誌論文(journal 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