{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233539564672.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/srep38561"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep38561.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep38561"}},{"identifier":{"@type":"PMID","@value":"27934941"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on <jats:italic>cnm</jats:italic>-positive <jats:italic>Streptococcus mutans</jats:italic> is involved in the development of CMBs. However, whether the collagen binding activity of <jats:italic>cnm</jats:italic>-positive <jats:italic>S. mutans</jats:italic> is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of <jats:italic>cnm</jats:italic>-positive <jats:italic>S. mutans</jats:italic> in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive <jats:italic>S. mutans</jats:italic> was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with <jats:italic>S. mutans</jats:italic> expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with <jats:italic>cnm</jats:italic>-positive <jats:italic>S. mutans</jats:italic> expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233539564549","@type":"Researcher","foaf:name":[{"@value":"Isao Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233539564800","@type":"Researcher","foaf:name":[{"@value":"Nagato Kuriyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233539564545","@type":"Researcher","foaf:name":[{"@value":"Fumitaro Miyatani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233539564428","@type":"Researcher","foaf:name":[{"@value":"Ryota Nomura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233539564551","@type":"Researcher","foaf:name":[{"@value":"Shuhei Naka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233539564811","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko 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LLC"}],"prism:publicationDate":"2016-12-09","prism:volume":"6","prism:number":"1","prism:startingPage":"38561"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/srep38561.pdf"},{"@id":"https://www.nature.com/articles/srep38561"}],"createdAt":"2016-12-09","modifiedAt":"2023-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mouth","dc:title":"Mouth"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Imaging","dc:title":"Magnetic Resonance Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Streptococcus%20mutans","dc:title":"Streptococcus mutans"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk 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