{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233663634176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1042/cs20180432"}},{"identifier":{"@type":"URI","@value":"https://portlandpress.com/clinsci/article-pdf/132/19/2147/449945/cs-2018-0432.pdf"}},{"identifier":{"@type":"DOI","@value":"10.3929/ethz-b-000302365"}},{"identifier":{"@type":"HANDLE","@value":"20.500.11850/302365"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Local cyclical compression modulates macrophage function<i>in situ</i>and alleviates immobilization-induced muscle atrophy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Physical inactivity gives rise to numerous diseases and organismal dysfunctions, particularly those related to aging. Musculoskeletal disorders including muscle atrophy, which can result from a sedentary lifestyle, aggravate locomotive malfunction and evoke a vicious circle leading to severe functional disruptions of vital organs such as the brain and cardiovascular system. Although the significance of physical activity is evident, molecular mechanisms behind its beneficial effects are poorly understood. Here, we show that massage-like mechanical interventions modulate immobilization-induced pro-inflammatory responses of macrophages in situ and alleviate muscle atrophy. Local cyclical compression (LCC) on mouse calves, which generates intramuscular pressure waves with amplitude of 50 mmHg, partially restores the myofiber thickness and contracting forces of calf muscles that are decreased by hindlimb immobilization. LCC tempers the increase in the number of cells expressing pro-inflammatory proteins, tumor necrosis factor-α and monocyte chemoattractant protein-1 (MCP-1), including macrophages in situ. The reversing effect of LCC on immobilization-induced thinning of myofibers is almost completely nullified when macrophages recruited from circulating blood are depleted by administration of clodronate liposomes. Furthermore, application of pulsatile fluid shear stress, but not hydrostatic pressure, reduces the expression of MCP-1 in macrophages in vitro. Together with the LCC-induced movement of intramuscular interstitial fluid detected by µCT analysis, these results suggest that mechanical modulation of macrophage function is involved in physical inactivity-induced muscle atrophy and inflammation. Our findings uncover the implication of mechanosensory function of macrophages in disuse muscle atrophy, thereby opening a new path to develop a novel therapeutic strategy utilizing mechanical interventions.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233663634188","@type":"Researcher","foaf:name":[{"@value":"Kumiko Saitou"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"},{"@value":"Graduate School of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634189","@type":"Researcher","foaf:name":[{"@value":"Masakuni Tokunaga"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634328","@type":"Researcher","foaf:name":[{"@value":"Daisuke Yoshino"}],"jpcoar:affiliationName":[{"@value":"Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3 Aramaki-aza-Aoba, Aoba, Sendai, Miyagi 980-8578, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634561","@type":"Researcher","foaf:name":[{"@value":"Naoyoshi Sakitani"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634568","@type":"Researcher","foaf:name":[{"@value":"Takahiro Maekawa"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634178","@type":"Researcher","foaf:name":[{"@value":"Youngjae Ryu"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634321","@type":"Researcher","foaf:name":[{"@value":"Motoshi Nagao"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634329","@type":"Researcher","foaf:name":[{"@value":"Hideki Nakamoto"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634445","@type":"Researcher","foaf:name":[{"@value":"Taku Saito"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634439","@type":"Researcher","foaf:name":[{"@value":"Noriaki Kawanishi"}],"jpcoar:affiliationName":[{"@value":"Faculty of Advanced Engineering, Chiba Institute of Technology, 2-1-1 Shibazono, Narashino, Chiba 275-0023, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634444","@type":"Researcher","foaf:name":[{"@value":"Katsuhiko Suzuki"}],"jpcoar:affiliationName":[{"@value":"Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634435","@type":"Researcher","foaf:name":[{"@value":"Toru Ogata"}],"jpcoar:affiliationName":[{"@value":"Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634450","@type":"Researcher","foaf:name":[{"@value":"Michiru Makuuchi"}],"jpcoar:affiliationName":[{"@value":"Section of Neuropsychology, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634433","@type":"Researcher","foaf:name":[{"@value":"Atsushi Takashima"}],"jpcoar:affiliationName":[{"@value":"Department of Assistive Technology, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233663634564","@type":"Researcher","foaf:name":[{"@value":"Keisuke Sawada"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Cell Pathology Division, The Children’s Hospital of 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