{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233977489792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m111.231415"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820574127?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820574127?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M111.231415"}},{"identifier":{"@type":"PMID","@value":"21712379"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Implication of Ca2+ in the Regulation of Replicative Life Span of Budding Yeast"}],"description":[{"notation":[{"@value":"In eukaryotic cells, Ca(2+)-triggered signaling pathways are used to regulate a wide variety of cellular processes. Calcineurin, a highly conserved Ca(2+)/calmodulin-dependent protein phosphatase, plays key roles in the regulation of diverse biological processes in organisms ranging from yeast to humans. We isolated a mutant of the SIR3 gene, implicated in the regulation of life span, as a suppressor of the Ca(2+) sensitivity of zds1Δ cells in the budding yeast Saccharomyces cerevisiae. Therefore, we investigated a relationship between Ca(2+) signaling and life span in yeast. Here we show that Ca(2+) affected the replicative life span (RLS) of yeast. Increased external and intracellular Ca(2+) levels caused a reduction in their RLS. Consistently, the increase in calcineurin activity by either the zds1 deletion or the constitutively activated calcineurin reduced RLS. Indeed, the shortened RLS of zds1Δ cells was suppressed by the calcineurin deletion. Further, the calcineurin deletion per se promoted aging without impairing the gene silencing typically observed in short-lived sir mutants, indicating that calcineurin plays an important role in a regulation of RLS even under normal growth condition. Thus, our results indicate that Ca(2+) homeostasis/Ca(2+) signaling are required to regulate longevity in budding yeast."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233977489667","@type":"Researcher","foaf:name":[{"@value":"Ryohei Tsubakiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751136125440","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10343295"},{"@type":"NRID","@value":"1000010343295"},{"@type":"NRID","@value":"9000004193686"},{"@type":"NRID","@value":"9000390885055"},{"@type":"NRID","@value":"9000007039080"},{"@type":"NRID","@value":"9000390428368"},{"@type":"NRID","@value":"9000411640086"},{"@type":"NRID","@value":"9000242070035"},{"@type":"NRID","@value":"9000364818520"},{"@type":"NRID","@value":"9000242069901"},{"@type":"NRID","@value":"9000342803292"},{"@type":"NRID","@value":"9000397846566"},{"@type":"NRID","@value":"9000398453996"},{"@type":"NRID","@value":"9000018472377"},{"@type":"NRID","@value":"9000018469674"},{"@type":"NRID","@value":"9000396141979"},{"@type":"NRID","@value":"9000267773460"},{"@type":"NRID","@value":"9000242901377"},{"@type":"NRID","@value":"9000007036873"},{"@type":"NRID","@value":"9000261040115"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/M-Mizu"}],"foaf:name":[{"@value":"Masaki Mizunuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233977489668","@type":"Researcher","foaf:name":[{"@value":"Anri Gengyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233977489794","@type":"Researcher","foaf:name":[{"@value":"Josuke Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276178527104","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80452613"},{"@type":"NRID","@value":"1000080452613"},{"@type":"NRID","@value":"9000001262237"},{"@type":"NRID","@value":"9000390885049"},{"@type":"NRID","@value":"9000018469666"},{"@type":"NRID","@value":"9000242070042"},{"@type":"NRID","@value":"9000316618755"},{"@type":"NRID","@value":"9000406304977"},{"@type":"NRID","@value":"9000242069900"},{"@type":"NRID","@value":"9000242070233"},{"@type":"NRID","@value":"9000018576987"},{"@type":"NRID","@value":"9000261040111"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000028287"}],"foaf:name":[{"@value":"Kazunori Kume"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233977489669","@type":"Researcher","foaf:name":[{"@value":"Tokichi Miyakawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420285329316505344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30243603"},{"@type":"NRID","@value":"1000030243603"},{"@type":"NRID","@value":"9000020823396"},{"@type":"NRID","@value":"9000004193689"},{"@type":"NRID","@value":"9000390885047"},{"@type":"NRID","@value":"9000018514933"},{"@type":"NRID","@value":"9000409508684"},{"@type":"NRID","@value":"9000020838847"},{"@type":"NRID","@value":"9000018469670"},{"@type":"NRID","@value":"9000242070043"},{"@type":"NRID","@value":"9000364818519"},{"@type":"NRID","@value":"9000021864775"},{"@type":"NRID","@value":"9000242069893"},{"@type":"NRID","@value":"9000242070236"},{"@type":"NRID","@value":"9000253472032"},{"@type":"NRID","@value":"9000010345722"},{"@type":"NRID","@value":"9000004182491"},{"@type":"NRID","@value":"9000412259738"},{"@type":"NRID","@value":"9000394966228"},{"@type":"NRID","@value":"9000387918203"},{"@type":"NRID","@value":"9000001446645"},{"@type":"NRID","@value":"9000267773463"},{"@type":"NRID","@value":"9000363286282"},{"@type":"NRID","@value":"9000261040117"},{"@type":"NRID","@value":"9000020846708"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/dh621229"}],"foaf:name":[{"@value":"Dai Hirata"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2011-08","prism:volume":"286","prism:number":"33","prism:startingPage":"28681","prism:endingPage":"28687"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021925820574127?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021925820574127?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M111.231415"}],"createdAt":"2011-06-29","modifiedAt":"2022-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Calcineurin","dc:title":"Calcineurin"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium","dc:title":"Calcium"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium%20Signaling","dc:title":"Calcium Signaling"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Silencing","dc:title":"Gene Silencing"},{"@id":"https://cir.nii.ac.jp/all?q=Saccharomyces%20cerevisiae","dc:title":"Saccharomyces cerevisiae"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Silent%20Information%20Regulator%20Proteins,%20Saccharomyces%20cerevisiae","dc:title":"Silent Information Regulator Proteins, Saccharomyces cerevisiae"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782036283008","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20380063"},{"@type":"JGN","@value":"JP20380063"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380063/"}],"notation":[{"@language":"ja","@value":"酵母の細胞極性制御に関する基礎および応用研究"},{"@language":"en","@value":"Basic and applied research on cell polarity control yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782096551040","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21780095"},{"@type":"JGN","@value":"JP21780095"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21780095/"}],"notation":[{"@language":"ja","@value":"カルシウムシグナルによる酵母の寿命制御機構"},{"@language":"en","@value":"Role of the Ca2+ signaling pathway in the regulation of the life span in yeast"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235458590592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pisiferdiol restores the growth of a mutant yeast suffering from hyperactivated Ca<sup>2+</sup>signalling through calcineurin inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144332345728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cooperation of Calcineurin and Vacuolar H+-ATPase in Intracellular 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cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620032603008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Calcineurin, the Ca<sup>2+</sup>/Calmodulin-Dependent Protein Phosphatase, Is Essential in Yeast Mutants with Cell Integrity Defects and in Mutants That Lack a Functional Vacuolar H<sup>+</sup>-Atpase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620162376448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two paralogs involved in transcriptional silencing that antagonistically control yeast life span"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093816626816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy genes mediate the effect of calcineurin on life span in<i>C. elegans</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094513775872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094819108608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Feedback Inhibition on Cell Wall Integrity Signaling by Zds1 Involves Gsk3 Phosphorylation of a cAMP-dependent Protein Kinase Regulatory Subunit"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569920064512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations in the Homologous\n                    <i>ZDS1</i>\n                    and\n                    <i>ZDS2</i>\n                    Genes Affect Cell Cycle Progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043821736064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045588127744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Calcineurin: From structure to function"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045806161920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genes determining yeast replicative life span in a long-lived genetic background"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046483167104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Budding Yeast Silencing Complexes and Regulation of Sir2 Activity by Protein-Protein Interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519179497728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How does calorie restriction work?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519672047488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521190176000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-\n            <i>O-</i>\n            acetyl-ADP-ribose"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994257635712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast."}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995592851200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470028976768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Requirement of NAD and\n                    <i>SIR2</i>\n                    for Life-Span Extension by Calorie Restriction in\n                    <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470263476736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470901704320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470967724032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944582148736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945586079488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spatial regulation of Cdc55–PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945773247360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Calcineurin Inhibits\n                    <i>VCX</i>\n                    1-Dependent H\n                    <sup>+</sup>\n                    /Ca\n                    <sup>2</sup>\n                    + Exchange and Induces Ca\n                    <sup>2</sup>\n                    + ATPases in\n                    <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418436439296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418520104192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419326800256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extrachromosomal rDNA Circles— A Cause of Aging in Yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419937406080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of calcineurin‐dependent degradation of Yap1p in Ca\n                    <sup>2+</sup>\n                    ‐induced G\n                    <sub>2</sub>\n                    cell‐cycle regulation in\n                    <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420254184832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pkc1 Acts Through Zds1 and Gic1 to Suppress Growth and Cell Polarity Defects of a Yeast eIF5A Mutant"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894109078272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894770130816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895957587072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896181015168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368234856832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369048881536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changes of telomere length cause reciprocal changes in the lifespan of mother cells in \n            <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371026818176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843280940160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Implication of Pkc1p protein kinase C in sustaining Cln2p level and polarized bud growth in response to calcium signaling in<i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843600024448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>TLC1</i>\n            : Template RNA Component of\n            <i>Saccharomyces cerevisiae</i>\n            Telomerase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843659647104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844707389440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An unusual form of transcriptional silencing in yeast ribosomal DNA."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846212083840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Phenomics Approach in Yeast Links Proton and Calcium Pump Function in the Golgi"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846212457344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>ZDS1</i> and <i>ZDS2</i>, Genes Whose Products May Regulate Cdc42p in <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318591979776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elevated cytosolic free Ca<sup>2+</sup> concentrations and massive Ca<sup>2+</sup> accumulation within vacuoles, in yeast mutant lacking <i>PMR1</i>, a homolog of Ca<sup>2+</sup>‐ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319649335552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320052190848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae."}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320393132672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Four Genes Responsible for a Position Effect on Expression From <i>HML</i> and <i>HMR</i> in <i>Saccharomyces cerevisiae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321137720960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[10] Yeast promoters and lacZ fusions designed to 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