{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004233980209792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m113.476010"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820486260?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820486260?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M113.476010"}},{"identifier":{"@type":"PMID","@value":"24043630"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The Unfolded Protein Response Transducer ATF6 Represents a Novel Transmembrane-type Endoplasmic Reticulum-associated Degradation Substrate Requiring Both Mannose Trimming and SEL1L Protein"}],"description":[{"notation":[{"@value":"Proteins misfolded in the endoplasmic reticulum (ER) are cleared by the ubiquitin-dependent proteasome system in the cytosol, a series of events collectively termed ER-associated degradation (ERAD). It was previously shown that SEL1L, a partner protein of the E3 ubiquitin ligase HRD1, is required for degradation of misfolded luminal proteins (ERAD-Ls substrates) but not misfolded transmembrane proteins (ERAD-Lm substrates) in both mammalian and chicken DT40 cells. Here, we analyzed ATF6, a type II transmembrane glycoprotein that serves as a sensor/transducer of the unfolded protein response, as a potential ERAD-Lm substrate in DT40 cells. Unexpectedly, degradation of endogenous ATF6 and exogenously expressed chicken and human ATF6 by the proteasome required SEL1L. Deletion analysis revealed that the luminal region of ATF6 is a determinant for SEL1L-dependent degradation. Chimeric analysis showed that the luminal region of ATF6 confers SEL1L dependence on type I transmembrane protein as well. In contrast, degradation of other known type I ERAD-Lm substrates (BACE457, T-cell receptor-α, CD3-δ, and CD147) did not require SEL1L. Thus, ATF6 represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature. In addition, endogenous ATF6 was markedly stabilized in wild-type cells treated with kifunensine, an inhibitor of α1,2-mannosidase in the ER, indicating that degradation of ATF6 requires proper mannose trimming. Our further analyses revealed that the five ERAD-Lm substrates examined are classified into three subgroups based on their dependence on mannose trimming and SEL1L. Thus, ERAD-Lm substrates are degraded through much more diversified mechanisms in higher eukaryotes than previously thought."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004233980209920","@type":"Researcher","foaf:name":[{"@value":"Satoshi Horimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233980209796","@type":"Researcher","foaf:name":[{"@value":"Satoshi Ninagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233980209792","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Okada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233980209793","@type":"Researcher","foaf:name":[{"@value":"Hibiki Koba"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233980209795","@type":"Researcher","foaf:name":[{"@value":"Takehiro Sugimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233980209798","@type":"Researcher","foaf:name":[{"@value":"Yukiko Kamiya"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276171386880","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20211849"},{"@type":"NRID","@value":"1000020211849"},{"@type":"CINII_AUTHOR_ID","@value":"DA09932980"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA09932980#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA09932980"},{"@type":"NRID","@value":"9000002737619"},{"@type":"NRID","@value":"9000391644681"},{"@type":"NRID","@value":"9000311505596"},{"@type":"NRID","@value":"9000240040880"},{"@type":"NRID","@value":"9000346929598"},{"@type":"NRID","@value":"9000411827114"},{"@type":"NRID","@value":"9000401906058"},{"@type":"NRID","@value":"9000311788282"},{"@type":"NRID","@value":"9000414539384"},{"@type":"NRID","@value":"9000259336270"},{"@type":"NRID","@value":"9000311069943"},{"@type":"NRID","@value":"9000401542803"},{"@type":"NRID","@value":"9000390929950"},{"@type":"NRID","@value":"9000241967369"},{"@type":"NRID","@value":"9000351091513"},{"@type":"NRID","@value":"9000241964851"},{"@type":"NRID","@value":"9000401959948"},{"@type":"NRID","@value":"9000309175875"},{"@type":"NRID","@value":"9000001347579"},{"@type":"NRID","@value":"9000018891727"},{"@type":"NRID","@value":"9000310741640"},{"@type":"NRID","@value":"9000298902436"},{"@type":"NRID","@value":"9000409332791"},{"@type":"NRID","@value":"9000411372801"},{"@type":"NRID","@value":"9000283393036"},{"@type":"NRID","@value":"9000397821583"},{"@type":"NRID","@value":"9000413907314"},{"@type":"NRID","@value":"9000001034331"},{"@type":"NRID","@value":"9000390882494"},{"@type":"NRID","@value":"9000351101118"},{"@type":"NRID","@value":"9000362192685"},{"@type":"NRID","@value":"9000001951918"},{"@type":"NRID","@value":"9000018183624"},{"@type":"NRID","@value":"9000016907757"},{"@type":"NRID","@value":"9000414265585"},{"@type":"NRID","@value":"9000360556349"},{"@type":"NRID","@value":"9000253176896"},{"@type":"NRID","@value":"9000257895139"},{"@type":"NRID","@value":"9000402900303"},{"@type":"NRID","@value":"9000017387709"},{"@type":"NRID","@value":"9000412364441"},{"@type":"NRID","@value":"9000399261256"},{"@type":"NRID","@value":"9000317153784"},{"@type":"NRID","@value":"9000014654924"},{"@type":"NRID","@value":"9000294331206"},{"@type":"NRID","@value":"9000261018987"},{"@type":"NRID","@value":"9000409882868"},{"@type":"NRID","@value":"9000018393213"},{"@type":"NRID","@value":"9000406405645"},{"@type":"NRID","@value":"9000253181416"},{"@type":"NRID","@value":"9000001276223"},{"@type":"NRID","@value":"9000024513672"},{"@type":"NRID","@value":"9000253163499"},{"@type":"NRID","@value":"9000253682458"},{"@type":"NRID","@value":"9000399603633"},{"@type":"NRID","@value":"9000391645562"},{"@type":"NRID","@value":"9000257735195"},{"@type":"NRID","@value":"9000399551617"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0150486"}],"foaf:name":[{"@value":"Koichi Kato"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751152546816","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60188191"},{"@type":"NRID","@value":"1000060188191"},{"@type":"CINII_AUTHOR_ID","@value":"DA13634636"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA13634636#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA13634636"},{"@type":"NRID","@value":"9000003008266"},{"@type":"NRID","@value":"9000237870126"},{"@type":"NRID","@value":"9000242883170"},{"@type":"NRID","@value":"9000391959805"},{"@type":"NRID","@value":"9000364830442"},{"@type":"NRID","@value":"9000237868496"},{"@type":"NRID","@value":"9000345441720"},{"@type":"NRID","@value":"9000408426638"},{"@type":"NRID","@value":"9000347048379"},{"@type":"NRID","@value":"9000347361786"},{"@type":"NRID","@value":"9000311069939"},{"@type":"NRID","@value":"9000403976150"},{"@type":"NRID","@value":"9000007409132"},{"@type":"NRID","@value":"9000364815688"},{"@type":"NRID","@value":"9000364831984"},{"@type":"NRID","@value":"9000005057774"},{"@type":"NRID","@value":"9000024686120"},{"@type":"NRID","@value":"9000347049193"},{"@type":"NRID","@value":"9000255959890"},{"@type":"NRID","@value":"9000010430868"},{"@type":"NRID","@value":"9000317127701"},{"@type":"NRID","@value":"9000024268876"},{"@type":"NRID","@value":"9000250183047"},{"@type":"NRID","@value":"9000402395289"},{"@type":"NRID","@value":"9000319553366"},{"@type":"NRID","@value":"9000240102514"},{"@type":"NRID","@value":"9000009097361"},{"@type":"NRID","@value":"9000398647307"},{"@type":"NRID","@value":"9000018894577"},{"@type":"NRID","@value":"9000024759944"},{"@type":"NRID","@value":"9000287286177"},{"@type":"NRID","@value":"9000391980260"},{"@type":"NRID","@value":"9000364830783"},{"@type":"NRID","@value":"9000364830558"},{"@type":"NRID","@value":"9000005048733"},{"@type":"NRID","@value":"9000398647278"},{"@type":"NRID","@value":"9000391982439"},{"@type":"NRID","@value":"9000391983855"},{"@type":"NRID","@value":"9000356567789"},{"@type":"NRID","@value":"9000364823663"},{"@type":"NRID","@value":"9000364825249"},{"@type":"NRID","@value":"9000347049091"},{"@type":"NRID","@value":"9000364828383"},{"@type":"NRID","@value":"9000388538398"},{"@type":"NRID","@value":"9000391979275"},{"@type":"NRID","@value":"9000255959885"},{"@type":"NRID","@value":"9000364829528"},{"@type":"NRID","@value":"9000347361583"},{"@type":"NRID","@value":"9000009353218"},{"@type":"NRID","@value":"9000242104116"},{"@type":"NRID","@value":"9000364829435"},{"@type":"NRID","@value":"9000359903827"},{"@type":"NRID","@value":"9000256198158"},{"@type":"NRID","@value":"9000365497585"},{"@type":"NRID","@value":"9000347667775"},{"@type":"NRID","@value":"9000238936602"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0080503"}],"foaf:name":[{"@value":"Shunichi Takeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004233980209799","@type":"Researcher","foaf:name":[{"@value":"Kazutoshi Mori"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-11","prism:volume":"288","prism:number":"44","prism:startingPage":"31517","prism:endingPage":"31527"},"reviewed":"false","invited":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021925820486260?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021925820486260?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M113.476010"}],"createdAt":"2013-09-17","modifiedAt":"2021-12-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Stability","dc:title":"Protein Stability"},{"@id":"https://cir.nii.ac.jp/all?q=Proteins","dc:title":"Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Endoplasmic%20Reticulum-Associated%20Degradation","dc:title":"Endoplasmic Reticulum-Associated Degradation"},{"@id":"https://cir.nii.ac.jp/all?q=Antidepressive%20Agents","dc:title":"Antidepressive Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Activating%20Transcription%20Factor%206","dc:title":"Activating Transcription Factor 6"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Substrate%20Specificity","dc:title":"Substrate Specificity"},{"@id":"https://cir.nii.ac.jp/all?q=Alkaloids","dc:title":"Alkaloids"},{"@id":"https://cir.nii.ac.jp/all?q=Phenelzine","dc:title":"Phenelzine"},{"@id":"https://cir.nii.ac.jp/all?q=Mannosidases","dc:title":"Mannosidases"},{"@id":"https://cir.nii.ac.jp/all?q=Proteolysis","dc:title":"Proteolysis"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Inhibitors","dc:title":"Enzyme Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Chickens","dc:title":"Chickens"},{"@id":"https://cir.nii.ac.jp/all?q=Mannose","dc:title":"Mannose"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782142478848","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23221005"},{"@type":"JGN","@value":"JP23221005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23221005/"}],"notation":[{"@language":"ja","@value":"遺伝子破壊細胞を使った、化学物質の生物効果をハイスループットに解析するシステム"},{"@language":"en","@value":"Establishment of high-throughput screening of toxic chemical compounds."}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782194247296","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24249002"},{"@type":"JGN","@value":"JP24249002"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24249002/"}],"notation":[{"@language":"ja","@value":"糖鎖認識系を標的とする創薬を目指した複合糖質機能の構造基盤の解明と分子設計"},{"@language":"en","@value":"Elucidation of structural basis of glycoconjugate functions and its application for molecular design toward developing drugs targeting the carbohydrate recognition systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782233708544","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25102001"},{"@type":"JGN","@value":"JP25102001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25102001/"}],"notation":[{"@language":"ja","@value":"生命分子システムにおける動的秩序形成と高次機能発現の研究に関する総括"},{"@language":"en","@value":"Management for Dynamical ordering of biomolecular systems for creation of integrated functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257210473216","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25102008"},{"@type":"JGN","@value":"JP25102008"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25102008/"}],"notation":[{"@language":"ja","@value":"生命分子の動的秩序形成におけるミクロ‐マクロ相関の探査と設計原理の探求"},{"@language":"en","@value":"Exploration of micro-macro relationships in dynamic ordering of biomolecular systems and their underlying design principles"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050008520278744320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD"}]},{"@id":"https://cir.nii.ac.jp/crid/1050287142172198144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1050302547375838592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins"},{"@value":"UGGT1-mediated reglucosylation of\n                  <i>N</i>\n                  -glycan competes with ER-associated degradation of unstable and misfolded glycoproteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285750232192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step."},{"@value":"EDEM2 initiates mammalian glycoprotein ERAD by catalysing the first mannose trimming step"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285769819520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway."}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760699911296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish."},{"@value":"ATF6alpha/beta-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1050846638692947712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD"},{"@value":"EDEM2 stable disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215888305280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217386585344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231508127872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Application of NanoBiT for Monitoring Dimerization of the Null Hong Kong Variant of α-1-Antitrypsin, NHK, in Living Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145377624704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cleaning Up: ER-Associated Degradation to the Rescue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390581927296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693782569088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619880477952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620092734848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620189182848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EDEM3, a Soluble EDEM Homolog, Enhances Glycoprotein Endoplasmic Reticulum-associated Degradation and Mannose Trimming"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620669043456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621004949504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866843171456","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"UGGT1/2-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181994201984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent technical developments in the study of ER-associated degradation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183935090304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568464321817088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of the ER‐bound transcription factor Luman/CREB3 in HEK293 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093475641600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ERAD substrate recognition in budding yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118678636928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum-Associated Degradation Controls Virus Protein Homeostasis, Which Is Required for Flavivirus Propagation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232163805696","@type":"Article","resourceType":"学術雑誌論文(journal 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