{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234173281920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/09168451.2018.1452602"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/bbb/article-pdf/82/7/1252/36845296/bbb1252.pdf"}},{"identifier":{"@type":"DOI","@value":"10.6084/m9.figshare.6010589"}},{"identifier":{"@type":"DOI","@value":"10.6084/m9.figshare.6010589.v1"}},{"identifier":{"@type":"PMID","@value":"29558858"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Metabolic engineering of <i>Corynebacterium glutamicum</i> for production of sunscreen shinorine"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Ultraviolet-absorbing chemicals are useful in cosmetics and skin care to prevent UV-induced skin damage. We demonstrate here that heterologous production of shinorine, which shows broad absorption maxima in the UV-A and UV-B region. A shinorine producing Corynebacterium glutamicum strain was constructed by expressing four genes from Actinosynnema mirum DSM 43827, which are responsible for the biosynthesis of shinorine from sedoheptulose-7-phosphate in the pentose phosphate pathway. Deletion of transaldolase encoding gene improved shinorine production by 5.2-fold. Among the other genes in pentose phosphate pathway, overexpression of 6-phosphogluconate dehydrogenase encoding gene further increased shinorine production by 60% (19.1 mg/L). The genetic engineering of the pentose phosphate pathway in C. glutamicum improved shinorine production by 8.3-fold in total, and could be applied to produce the other chemicals derived from sedoheptulose-7-phosphate.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326205398400","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00647422"},{"@type":"NRID","@value":"1000000647422"},{"@type":"NRID","@value":"9000411489309"},{"@type":"NRID","@value":"9000018470116"},{"@type":"NRID","@value":"9000394467373"},{"@type":"NRID","@value":"9000261040240"},{"@type":"NRID","@value":"9000261641104"},{"@type":"NRID","@value":"9000399796393"},{"@type":"NRID","@value":"9000409594012"},{"@type":"NRID","@value":"9000409594016"},{"@type":"NRID","@value":"9000414835063"},{"@type":"NRID","@value":"9000399796699"},{"@type":"NRID","@value":"9000395364526"},{"@type":"NRID","@value":"9000402452933"},{"@type":"NRID","@value":"9000402126007"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/647422"}],"foaf:name":[{"@value":"Yota Tsuge"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Natural Science and Technology, Kanazawa University , Kanazawa, Japan"},{"@value":"Institute for Frontier Science Initiative, Kanazawa University , Kanazawa, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234173281792","@type":"Researcher","foaf:name":[{"@value":"Hideo Kawaguchi"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Science, Technology and Innovation, Kobe University , Kobe, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234173281921","@type":"Researcher","foaf:name":[{"@value":"Shogo Yamamoto"}],"jpcoar:affiliationName":[{"@value":"Nagase R&D Center, Nagase & Co., Ltd ., Kobe, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234173281795","@type":"Researcher","foaf:name":[{"@value":"Yoshiko Nishigami"}],"jpcoar:affiliationName":[{"@value":"Nagase R&D Center, Nagase & Co., Ltd ., Kobe, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234173281922","@type":"Researcher","foaf:name":[{"@value":"Masahiro Sota"}],"jpcoar:affiliationName":[{"@value":"Nagase R&D Center, Nagase & Co., Ltd ., Kobe, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234173281920","@type":"Researcher","foaf:name":[{"@value":"Chiaki Ogino"}],"jpcoar:affiliationName":[{"@value":"Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University , Kobe, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234173281793","@type":"Researcher","foaf:name":[{"@value":"Akihiko Kondo"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Science, Technology and Innovation, Kobe University , Kobe, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09168451"},{"@type":"EISSN","@value":"13476947"}],"prism:publicationName":[{"@value":"Bioscience, Biotechnology, and Biochemistry"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2018-07-03","prism:volume":"82","prism:number":"7","prism:startingPage":"1252","prism:endingPage":"1259"},"reviewed":"false","dc:rights":["https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"],"url":[{"@id":"http://academic.oup.com/bbb/article-pdf/82/7/1252/36845296/bbb1252.pdf"}],"createdAt":"2018-03-21","modifiedAt":"2022-06-07","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Recombination,%20Genetic","dc:title":"Recombination, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclohexylamines","dc:title":"Cyclohexylamines"},{"@id":"https://cir.nii.ac.jp/all?q=Ultraviolet%20Rays","dc:title":"Ultraviolet Rays"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphogluconate%20Dehydrogenase","dc:title":"Phosphogluconate Dehydrogenase"},{"@id":"https://cir.nii.ac.jp/all?q=Glycine","dc:title":"Glycine"},{"@id":"https://cir.nii.ac.jp/all?q=Mass%20Spectrometry","dc:title":"Mass Spectrometry"},{"@id":"https://cir.nii.ac.jp/all?q=Transaldolase","dc:title":"Transaldolase"},{"@id":"https://cir.nii.ac.jp/all?q=Actinobacteria","dc:title":"Actinobacteria"},{"@id":"https://cir.nii.ac.jp/all?q=Corynebacterium%20glutamicum","dc:title":"Corynebacterium glutamicum"},{"@id":"https://cir.nii.ac.jp/all?q=Pentose%20Phosphate%20Pathway","dc:title":"Pentose Phosphate Pathway"},{"@id":"https://cir.nii.ac.jp/all?q=Metabolic%20Engineering","dc:title":"Metabolic Engineering"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Bacterial","dc:title":"Genes, Bacterial"},{"@id":"https://cir.nii.ac.jp/all?q=Sugar%20Phosphates","dc:title":"Sugar Phosphates"},{"@id":"https://cir.nii.ac.jp/all?q=Sunscreening%20Agents","dc:title":"Sunscreening Agents"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256949001600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K14866"},{"@type":"JGN","@value":"JP17K14866"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K14866/"}],"notation":[{"@language":"ja","@value":"酸素に応答する代謝経路のスイッチング機構の解明と新規バイオプロセスへの応用"},{"@language":"en","@value":"Bidirectional switching of carbon flux between glycolysis and pentose phosphate pathway by oxygen level in Corynebacterium glutamicum"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282813897551872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards bacterial strains overproducing L-tryptophan and other aromatics by metabolic engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145491417472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Improvement of L-phenylalanine production from glycerol by recombinant Escherichia coli strains: The role of extra copies of glpK, glpX, and tktA genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693432610304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discovery of Gene Cluster for Mycosporine-Like Amino Acid Biosynthesis from Actinomycetales Microorganisms and Production of a Novel Mycosporine-Like Amino Acid by Heterologous Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619144433536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic Engineering of <i>Corynebacterium glutamicum</i> for Fuel Ethanol Production under Oxygen-Deprivation Conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620015682176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of 2-methyl-1-butanol and 3-methyl-1-butanol in engineered Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181143630592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of the phosphofructokinase encoding gene is crucial for achieving high production of D-lactate in Corynebacterium glutamicum under oxygen deprivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093522816000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"3-Methyl-1-butanol Biosynthesis in an Engineered Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095322858240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044317883776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of the membrane protein SucE and its role in succinate transport in Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046342894976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519592549504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Toward Homosuccinate Fermentation: Metabolic Engineering of Corynebacterium glutamicum for Anaerobic Production of Succinate from Glucose and Formate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520798661120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of para-aminobenzoate by genetically engineered Corynebacterium glutamicum and non-biological formation of an N-glucosyl byproduct"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468452998784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deletion of cgR_1596 and cgR_2070, Encoding NlpC/P60 Proteins, Causes a Defect in Cell Separation in\n            <i>Corynebacterium glutamicum</i>\n            R"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469230353920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Direct production of L-lysine from raw corn starch by Corynebacterium glutamicum secreting Streptococcus bovis α-amylase using cspB promoter and signal sequence"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470633125376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization and Molecular Mechanism of AroP as an Aromatic Amino Acid and Histidine Transporter in Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945896897664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ncgl1108 (PheP\nCg) gene encodes a new l-Phe transporter in Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418349888896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles of export genes cgmA and lysE for the production of l-arginine and l-citrulline by Corynebacterium glutamicum"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420179715072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Engineering Corynebacterium glutamicum for isobutanol production"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895136851456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reactions upstream of glycerate-1,3-bisphosphate drive Corynebacterium glutamicum d-lactate productivity under oxygen deprivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895522011136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic engineering of Corynebacterium glutamicum for shikimate overproduction by growth-arrested cell reaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371328562048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Corynebacterium glutamicum Tailored for Efficient Isobutanol Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843843632128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional analysis of sequences adjacent to dapE of Corynebacterium glutamicum reveals the presence of aroP, which encodes the aromatic amino acid transporter"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845399553920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Strain optimization for efficient isobutanol production using <i>Corynebacterium glutamicum</i> under oxygen deprivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318848435456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of succinate exporter in Corynebacterium glutamicum and its physiological roles under anaerobic conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795973512448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270634980736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206478670464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Metabolic Engineering of Corynebacterium glutamicum for Cadaverine Fermentation"},{"@value":"Metabolic Engineering of<i>Corynebacterium glutamicum</i>for Cadaverine Fermentation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679120939136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"STUDIES ON THE AMINO ACID FERMENTATION"},{"@value":"Studies on the amino acid fermentation part 1. Production of l-glutamic acid by various microorganisms"},{"@value":"Studies on the amino acid fermentation Part I. Production of L-glutamic acid by various microorganisms"},{"@value":"Studies on the amino acid fermentation. Production of l-glutamate by various microorganisms"},{"@value":"Studies on the amino acid fermentation. I. Production of L-glutamic acid by various microorganisms"},{"@value":"Studies of the amino acid fermentation. Part I. Production of l-glutamic acid by various microorganisms"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1080/09168451.2018.1452602"},{"@type":"KAKEN","@value":"PRODUCT-23149604"},{"@type":"KAKEN","@value":"PRODUCT-21547693"},{"@type":"OPENAIRE","@value":"doi_dedup___::3d4abc2e22e94b88d9dcd42bb1590d1c"}]}