{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234199296512.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/10253890.2017.1297415"}},{"identifier":{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.1080/10253890.2017.1297415"}},{"identifier":{"@type":"PMID","@value":"28285561"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Adverse parenting is associated with blunted salivary cortisol awakening response and altered expression of glucocorticoid receptor β and β2-adrenergic receptor mRNAs in leukocytes in Japanese medical students"}],"description":[{"notation":[{"@value":"Adverse parenting is associated with an increased risk for the development of mood and behavioral disorders. In this study, we assessed the perceived parental bonding of 232 medical students using the parental bonding instrument (PBI) and extracted 22 students who reported their parents' rearing attitudes as affectionless control (LOW; low care, high overprotection). Using the 28-item general health questionnaire, the Zung self-rating depression scale (Zung-SDS), the hospital anxiety and depression scale (HADS), and the Spielberger state-trait-anxiety-inventory (STAI), physical and mental state of the LOW students were compared with those of 30 students who reported their parental bonding as optimal (OPT; high care and low overprotection). These questionnaire measurements demonstrated significantly higher anxiety and depressive mood in the LOW students versus the OPT students. Compared with the OPT students, the LOW students also exhibited a significantly reduced salivary cortisol awakening response (CAR) without changes across the rest of the diurnal salivary cortisol profile. Among glucocorticoid-related genes examined (GR, ADRB2, IκBα, IL10, IL1R2, IL1RN, MR, MC2R, TGFB1, TGFB2 and FASLG), real-time reverse transcription-PCR showed that the LOW students significantly increased expression of a dominant negative glucocorticoid receptor β (GRβ) mRNA and decreased β2-adrenergic receptor (ADRB2) mRNA levels in circulating leukocytes. These results suggest that negative perception of parents' child-rearing attitudes may be associated with anxiety and depressive mood and altered glucocorticoid signaling even in healthy young adults."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004234199296514","@type":"Researcher","foaf:name":[{"@value":"Tomoko Kawai"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234199296515","@type":"Researcher","foaf:name":[{"@value":"Yuki Kuwano"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751135300608","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00457318"},{"@type":"NRID","@value":"1000000457318"},{"@type":"NRID","@value":"9000411500328"},{"@type":"NRID","@value":"9000367421729"},{"@type":"NRID","@value":"9000345230275"},{"@type":"NRID","@value":"9000257900391"},{"@type":"NRID","@value":"9000018278205"},{"@type":"NRID","@value":"9000356489017"},{"@type":"NRID","@value":"9000238236437"},{"@type":"NRID","@value":"9000411500349"},{"@type":"NRID","@value":"9000409883044"},{"@type":"NRID","@value":"9000411500310"},{"@type":"NRID","@value":"9000398993642"},{"@type":"NRID","@value":"9000356488954"},{"@type":"NRID","@value":"9000409014609"},{"@type":"NRID","@value":"9000398801910"},{"@type":"NRID","@value":"9000342443496"},{"@type":"NRID","@value":"9000411500375"},{"@type":"NRID","@value":"9000415309192"},{"@type":"NRID","@value":"9000375857179"},{"@type":"NRID","@value":"9000411500340"},{"@type":"NRID","@value":"9000411500358"},{"@type":"NRID","@value":"9000409781439"},{"@type":"NRID","@value":"9000283280544"},{"@type":"NRID","@value":"9000351205989"},{"@type":"NRID","@value":"9000402283872"},{"@type":"NRID","@value":"9000309991434"},{"@type":"NRID","@value":"9000378106670"},{"@type":"NRID","@value":"9000411500316"},{"@type":"NRID","@value":"9000398801917"},{"@type":"NRID","@value":"9000283281734"},{"@type":"NRID","@value":"9000411500369"},{"@type":"NRID","@value":"9000283281459"},{"@type":"NRID","@value":"9000411000611"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kiyoshi_masuda"}],"foaf:name":[{"@value":"Kiyoshi Masuda"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234199296640","@type":"Researcher","foaf:name":[{"@value":"Kinuyo Fujita"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234199296513","@type":"Researcher","foaf:name":[{"@value":"Hiroki Tanaka"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 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Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234199296386","@type":"Researcher","foaf:name":[{"@value":"Kensei Nishida"}],"jpcoar:affiliationName":[{"@value":"Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10253890"},{"@type":"EISSN","@value":"16078888"}],"prism:publicationName":[{"@value":"Stress"}],"dc:publisher":[{"@value":"Informa UK 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