{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234283211520.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/15548627.2016.1274850"}},{"identifier":{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1274850"}},{"identifier":{"@type":"PMID","@value":"28121218"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice"}],"description":[{"notation":[{"@value":"Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that autophagosome formation was accelerated, but autophagic clearance was impaired in obese adipose tissue. We also found protein and activity levels of CTSL (cathepsin L) were suppressed in obese adipose tissue, while the activity of CTSB (cathepsin B) was significantly enhanced. Moreover, cellular senescence and inflammasomes were activated in obese adipose tissue. In 3T3L1 adipocytes, downregulation of CTSL deteriorated autophagic clearance, upregulated expression of CTSB, promoted cellular senescence and activated inflammasomes. Upregulation of CTSB promoted additional activation of inflammasomes. Therefore, we suggest lysosomal dysfunction observed in obese adipose tissue leads to lower autophagic clearance, resulting in autophagosome accumulation. Simultaneously, lysosomal abnormalities, including deteriorated CTSL function and compensatory activation of CTSB, caused cellular senescence and inflammasome activation. Our findings strongly suggest lysosomal dysfunction is involved in early pathologies of obese adipose tissue."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004234283211520","@type":"Researcher","foaf:name":[{"@value":"Yuhei Mizunoe"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"},{"@value":"Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211394","@type":"Researcher","foaf:name":[{"@value":"Yuka Sudo"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"},{"@value":"Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211136","@type":"Researcher","foaf:name":[{"@value":"Naoyuki Okita"}],"jpcoar:affiliationName":[{"@value":"Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, Japan"},{"@value":"Department of Internal Medicine Research, Sasaki Institute, Sasaki Foundation, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211399","@type":"Researcher","foaf:name":[{"@value":"Hidenori Hiraoka"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211137","@type":"Researcher","foaf:name":[{"@value":"Kentaro Mikami"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211395","@type":"Researcher","foaf:name":[{"@value":"Tomohiro Narahara"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211521","@type":"Researcher","foaf:name":[{"@value":"Arisa Negishi"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211139","@type":"Researcher","foaf:name":[{"@value":"Miki Yoshida"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211138","@type":"Researcher","foaf:name":[{"@value":"Rikako Higashibata"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211396","@type":"Researcher","foaf:name":[{"@value":"Shukoh Watanabe"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211397","@type":"Researcher","foaf:name":[{"@value":"Hiroki Kaneko"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211398","@type":"Researcher","foaf:name":[{"@value":"Daiki Natori"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211393","@type":"Researcher","foaf:name":[{"@value":"Takuma Furuichi"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211392","@type":"Researcher","foaf:name":[{"@value":"Hiromine Yasukawa"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283211264","@type":"Researcher","foaf:name":[{"@value":"Masaki Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751155942528","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90253640"},{"@type":"NRID","@value":"1000090253640"},{"@type":"NRID","@value":"9000000531222"},{"@type":"NRID","@value":"9000020746206"},{"@type":"NRID","@value":"9000411804154"},{"@type":"NRID","@value":"9000004443561"},{"@type":"NRID","@value":"9000406387681"},{"@type":"NRID","@value":"9000381970753"},{"@type":"NRID","@value":"9000000432068"},{"@type":"NRID","@value":"9000002217184"},{"@type":"NRID","@value":"9000006958229"},{"@type":"NRID","@value":"9000023575091"},{"@type":"NRID","@value":"9000010645416"},{"@type":"NRID","@value":"9000406399091"},{"@type":"NRID","@value":"9000406387678"},{"@type":"NRID","@value":"9000413775271"},{"@type":"NRID","@value":"9000413501403"},{"@type":"NRID","@value":"9000399161622"},{"@type":"NRID","@value":"9000413510787"},{"@type":"NRID","@value":"9000272991079"},{"@type":"NRID","@value":"9000411779032"},{"@type":"NRID","@value":"9000406324941"},{"@type":"NRID","@value":"9000000730155"},{"@type":"NRID","@value":"9000414214378"},{"@type":"NRID","@value":"9000411795815"},{"@type":"NRID","@value":"9000253610255"},{"@type":"NRID","@value":"9000408891048"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0098910"}],"foaf:name":[{"@value":"Yoshikazu Higami"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan"},{"@value":"Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, Chiba, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15548627"},{"@type":"EISSN","@value":"15548635"}],"prism:publicationName":[{"@value":"Autophagy"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2017-02-17","prism:volume":"13","prism:number":"4","prism:startingPage":"642","prism:endingPage":"653"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc/3.0/"],"url":[{"@id":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1274850"}],"createdAt":"2017-01-25","modifiedAt":"2020-09-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Basic%20Research%20Papers","dc:title":"Basic Research Papers"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammasomes","dc:title":"Inflammasomes"},{"@id":"https://cir.nii.ac.jp/all?q=Adipose%20Tissue,%20White","dc:title":"Adipose Tissue, White"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagosomes","dc:title":"Autophagosomes"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy-Related%20Proteins","dc:title":"Autophagy-Related Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Obese","dc:title":"Mice, Obese"},{"@id":"https://cir.nii.ac.jp/all?q=Diet,%20High-Fat","dc:title":"Diet, High-Fat"},{"@id":"https://cir.nii.ac.jp/all?q=Cathepsins","dc:title":"Cathepsins"},{"@id":"https://cir.nii.ac.jp/all?q=Up-Regulation","dc:title":"Up-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=3T3-L1%20Cells","dc:title":"3T3-L1 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Adipocytes","dc:title":"Adipocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Obesity","dc:title":"Obesity"},{"@id":"https://cir.nii.ac.jp/all?q=Lysosomes","dc:title":"Lysosomes"},{"@id":"https://cir.nii.ac.jp/all?q=Cellular%20Senescence","dc:title":"Cellular Senescence"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781955275264","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H02179"},{"@type":"JGN","@value":"JP17H02179"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H02179/"}],"notation":[{"@language":"ja","@value":"リソソーム／ミトコンドリア相互作用破綻による脂肪組織肥満病態の解明と制御法の開発"},{"@language":"en","@value":"Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050289796566888448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845764130320896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218729445632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232474580864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142747957888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Taurine is an amino acid with the ability to activate autophagy in adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143938393984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145319280896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146185017472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168767087232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706976909824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706977319040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagosomes accumulate in differentiated and hypertrophic adipocytes in a p53-independent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618564512896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p62 at the Crossroads of Autophagy, Apoptosis, and Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618834431872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of the Activity of Lysosomal Cysteine Proteinases by pH-Induced Inactivation and/or Endogenous Protein Inhibitors, Cystatins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165776386304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165776422016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy regulates inflammation in adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092607643392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093709003392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094156436480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Specialized roles for cysteine cathepsins in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096433038592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845538941619072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640782439680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy: Renovation of Cells and Tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656931098112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibitory effect of p53 on mitochondrial content and function during adipogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707149718144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044278071936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046000880896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cholesterol Accumulation Is Associated with Lysosomal Dysfunction and Autophagic Stress in Npc1−/− Mouse Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046070620672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chapter 16 Novel Methods for Measuring Cardiac Autophagy In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519364851840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Physiological significance of selective degradation of p62 by autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520395372160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular senescence: when bad things happen to good cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993488886400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994145758208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995516908416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[41] Cathepsin B, cathepsin H, and cathepsin L"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975843972086400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468873095936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasomes in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946012697856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TFEB Links Autophagy to Lysosomal Biogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946453832832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methods in Mammalian Autophagy Research"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419089820288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420412759936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420511085312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421340986112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signals from the lysosome: a control centre for cellular clearance and energy metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893869657216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuronal loss and brain atrophy in mice lacking cathepsins B and L"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894327831296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteases in autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894362512256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894578716032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368378420864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasome is a central player in the induction of obesity and insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368467005184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Altered Autophagy in Human Adipose Tissues in Obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368784181248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369059891328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy fights disease through cellular self-digestion"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369103848320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of cathepsins B and L in inflammation and cholesterol trafficking protein NPC2 secretion in macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370327291520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy in the Pathogenesis of Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370834446080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370877147264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipid Synthetic Transcription Factor SREBP-1a Activates p21<sup>WAF1/CIP1</sup>, a Universal Cyclin-Dependent Kinase Inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843913858048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p53 Activation in Adipocytes of Obese Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844680565248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844752398336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Different telomere damage signaling pathways in human and mouse cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845263449472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipokines in inflammation and metabolic disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845383244160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319342978816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipose-specific deletion of\n                    <i>autophagy-related gene 7</i>\n                    (\n                    <i>atg7</i>\n                    ) in mice reveals a role in adipogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319683795584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of adipokines in complications related to obesity. A review"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320045864320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lysosomal membrane permeabilization in cell death"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320709610752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793706673152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793783935104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cysteine cathepsins: From structure, function and regulation to new frontiers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794025943808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794292958336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cathepsin L‐deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270105297024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NALP3 inflammasome is involved in the innate immune response to amyloid-β"}]},{"@id":"https://cir.nii.ac.jp/crid/1390002184875850496","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脂肪細胞の質の改善から創薬へ"},{"@value":"基礎教室紹介 脂肪細胞の質の改善から創薬へ"},{"@language":"ja-Kana","@value":"キソ キョウシツ ショウカイ シボウ サイボウ ノ シツ ノ カイゼン カラ ソウヤク エ"}]},{"@id":"https://cir.nii.ac.jp/crid/1883961342286561280","@type":"Dataset","relationType":["isSupplementedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of Lysosomal Dysfunction in Autophagosome Accumulation and Early Pathologies in Adipose Tissue of Obese Mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1080/15548627.2016.1274850"},{"@type":"KAKEN","@value":"PRODUCT-22537025"},{"@type":"OPENAIRE","@value":"doi_dedup___::2b4e320df70189f38ac7f56567edb0e6"},{"@type":"CROSSREF","@value":"10.1007/s00726-018-2550-6_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.1016/j.exger.2021.111519_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.1038/s41598-020-57428-6_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.1002/2211-5463.13055_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2022.113715_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.1016/j.redox.2017.09.007_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.1080/10715762.2020.1734588_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.3143/geriatrics.57.94_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"},{"@type":"CROSSREF","@value":"10.3390/ijms20153688_references_DOI_2zRwaOsnRigsEf20dyczPgxyGcH"}]}